News: HDAC

Throwing a Wrench in DNA Machinery

Thursday, December 9th, 2010

Proteins called HDACs are the targets of a new class of anti-cancer compounds (HDAC inhibitors). How these compounds kill tumor cells — and the potential side effects of such drugs — are still open questions. Scott Hiebert, Ph.D., and colleagues at Vanderbilt-Ingram Cancer Center have now discovered that mice missing a particular HDAC (pronounced h-dack) […]

DNA Mechanics

Wednesday, December 8th, 2010

Picture a railroad track, running across the countryside. DNA looks something like that track. Its “rails” are chains of chemicals called nucleotides, each pairing with a partner on the opposite chain to form the “ties.” To ensure timely train traffic – and prevent catastrophic derailments – the railroad track needs regular maintenance. So does DNA. […]