News: Journal of Clinical Investigation

Proteins May Point to Prostate Cancer Drug Targets

Tuesday, August 7th, 2012

Two proteins that act in opposing directions – one that promotes cancer and one that suppresses cancer — regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found. The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer. “We […]

Heart Protein May be Target for Colon Cancer Therapies

Friday, October 7th, 2011

A protein critical in heart development may also play a part in colon cancer progression. Research led by investigators fromVanderbilt-Ingram Cancer Center and the Vanderbilt Eye Institute suggests that the protein BVES (blood vessel endocardial substance) – which also is key in regulating corneal cells – may be a therapeutic target for halting colon cancer metastasis. The study, […]

Heart Protein Has Role in Colon Cancer

Tuesday, September 13th, 2011

A protein critical in heart development may also play a part in colon cancer progression. Research led by investigators from Vanderbilt-Ingram Cancer Center and the Vanderbilt Eye Institute suggests that the protein BVES (blood vessel endocardial substance) – which also is key in regulating corneal cells – may be a therapeutic target for halting colon […]

Six Subtypes Identified in Breast Cancer

Friday, July 8th, 2011

Vanderbilt-Ingram Cancer Center researchers have identified six subtypes of an aggressive and difficult-to-treat form of breast cancer, called “triple-negative breast cancer (TNBC).” In the July issue of the Journal of Clinical Investigation, Cancer Center Director Jennifer Pietenpol, Ph.D., and colleagues describe the molecular features of these six distinct subtypes and identify chemotherapies to which the […]