News: metaplasias

Variable Vulnerability to Oncogene

Friday, April 15th, 2011

Mutations that activate the Kras oncogene are common in many epithelial tumors, including cancers of the pancreas, colon and lung, but Kras mutations are rare in cancers of the oral cavity and stomach. Why some tissues are vulnerable to Kras mutations, and some are not, is unclear. To explore the susceptibility of different epithelial tissues […]