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VICC & Maury Regional Team Up for Radiation Oncology Spring Hill

Friday, June 21st, 2013

By Dagny Stuart Maury Regional Medical Center (MRMC) and Vanderbilt-Ingram Cancer Center (VICC) have joined forces to open a new radiation oncology treatment center for cancer patients in Spring Hill, Tenn. The radiation oncology facility, which has been named the Vanderbilt-Ingram Cancer Center at Maury Regional Spring Hill, is located at 1003 Reserve Boulevard near […]

Target Acquired for Aggressive Tumor

Friday, September 28th, 2012

Angiosarcoma, a rare, aggressive tumor that arises from cells that line blood vessels, has a mortality rate of around 80 percent. Because of their constant contact with the blood stream, these tumors can spread quickly and freely throughout the body. The INK4a/ARF locus on chromosome 9 – a region that encodes tumor suppressor proteins – […]

Grant Renewal Boosts GI Cancer Research Program

Friday, September 21st, 2012

Vanderbilt-Ingram Cancer Center’s gastrointestinal Specialized Program of Research Excellence (SPORE) has been awarded its third round of funding by the National Cancer Institute (NCI). “We decided to roll the dice and propose high-risk, high-reward projects,” said Robert Coffey Jr., M.D., Ingram Professor of Cancer Research, professor of Medicine and Cell and Developmental Biology, and director […]

HER2 May Impact Lung Cancer Therapy

Friday, September 21st, 2012

Overcoming therapeutic resistance that inevitably develops is one of the major challenges in treating lung cancer. Non-small cell lung cancers that harbor mutations in the epidermal growth factor receptor (EGFR) are initially responsive to targeted therapies known as EGFR tyrosine kinase inhibitors (TKIs). However, most patients eventually develop resistance to these therapies. One such targeted […]

New Method May Allow Personalized Clinical Trial for Cancer Therapies

Tuesday, August 14th, 2012

A new tool to observe cell behavior has revealed surprising clues about how cancer cells respond to therapy – and may offer a way to further refine personalized cancer treatments. The approach, developed by investigators at Vanderbilt-Ingram Cancer Center, shows that erlotinib – a targeted therapy that acts on a growth factor receptor mutated in […]

Study Tracks How Gene May Promote Lung Cancer Tumors

Friday, August 10th, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene — as often happens in lung cancer — diminishes this […]

NorthCrest Medical Center Opens Cancer Clinic

Thursday, August 9th, 2012

Vanderbilt-Ingram Cancer Center (VICC) has opened a new cancer outpatient clinic on the NorthCrest Medical Center campus in Springfield, Tenn., to bring high quality care to patients in Middle Tennessee and Southern Kentucky. Vanderbilt physicians, who are specialists in Medical Oncology and Hematology, will see patients in the new facility. The board-certified cancer specialists, led […]

Proteins May Point to Prostate Cancer Drug Targets

Tuesday, August 7th, 2012

Two proteins that act in opposing directions – one that promotes cancer and one that suppresses cancer — regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found. The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer. “We […]

Lung Cancer Mutations Suggest New Therapies

Tuesday, July 31st, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene – as often happens in lung cancer – diminishes this […]

Study Finds Stress Fuels Breast Cancer Metastasis to Bone

Wednesday, July 18th, 2012

Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. The studies, reported July 17 in PLoS Biology, demonstrate in mice that activation of the sympathetic nervous system – the “fight-or-flight” response to stress – primes the bone environment for breast cancer cell metastasis. The researchers were able […]