News: National Institute of Diabetes and Digestive and Kidney Diseases

Colon Cancer’s Cellular Crossroads

Friday, March 16th, 2012

Colon cancer development and progression involves alterations in several cell signaling pathways. Activation of the Wnt pathway is involved in the early stages of tumor development, while inactivation of signaling through the TGF-beta pathway (which typically suppresses tumor formation) is involved in later stages. However, the interactions between these pathways remain unclear. R. Daniel Beauchamp, […]

Protein Family Linked to Suppressing Tumors

Friday, October 28th, 2011

The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health (NIH). The new study, published Oct. 17 in Cancer Cell, identifies the protein SIRT2 as a tumor suppressor linked to gender-specific tumor development in mice. Along […]

Lymphoma Factor Amps Up Metabolism

Friday, October 7th, 2011

The functions of most members of the enzyme family known as poly (ADP-ribose) polymerases (PARPs) are unclear. Some PARP-related proteins are in a B aggressive lymphoma (BAL) protein family, which are highly expressed in certain types of B cell lymphomas – malignancies of the antibody-producing B lymphocytes. Sung Hoon Cho, Ph.D., Mark Boothby, M.D., Ph.D., […]