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Target Acquired for Aggressive Tumor

Friday, September 28th, 2012

Angiosarcoma, a rare, aggressive tumor that arises from cells that line blood vessels, has a mortality rate of around 80 percent. Because of their constant contact with the blood stream, these tumors can spread quickly and freely throughout the body. The INK4a/ARF locus on chromosome 9 – a region that encodes tumor suppressor proteins – […]

Grant Renewal Boosts GI Cancer Research Program

Friday, September 21st, 2012

Vanderbilt-Ingram Cancer Center’s gastrointestinal Specialized Program of Research Excellence (SPORE) has been awarded its third round of funding by the National Cancer Institute (NCI). “We decided to roll the dice and propose high-risk, high-reward projects,” said Robert Coffey Jr., M.D., Ingram Professor of Cancer Research, professor of Medicine and Cell and Developmental Biology, and director […]

Study Tracks How Gene May Promote Lung Cancer Tumors

Friday, August 10th, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene — as often happens in lung cancer — diminishes this […]

Proteins May Point to Prostate Cancer Drug Targets

Tuesday, August 7th, 2012

Two proteins that act in opposing directions – one that promotes cancer and one that suppresses cancer — regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found. The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer. “We […]

Kids’ Cells Okay After Maternal Cancer

Friday, June 22nd, 2012

Mitochondria – cellular structures known as the “power plants” of the cell – are inherited exclusively from the mother. These organelles contain their own DNA (mtDNA), which is highly vulnerable to damage by environmental insults – for example radiation exposure to the ovaries during treatment for childhood cancer. Because such damage could be passed on […]

Gene Database to Aid Disease Research

Wednesday, June 13th, 2012

Next generation sequencing (NGS) has dramatically accelerated the discovery of disease-associated genetic variants. Also known as massively parallel sequencing, this technological tour de force can rapidly “read” a sequence of DNA bases (the “letters” in our genomes) in parallel, making genome sequencing feasible in the research lab. Vanderbilt researchers have developed a “catalog” of human […]

Roots of Childhood Brain Tumors

Wednesday, June 13th, 2012

Identifying the cellular origins of medulloblastoma – the most common malignant brain tumor in children – may help focus treatment on cell types responsible for tumor initiation. Previous research has linked Sonic hedgehog signaling in neuronal cell precursors within the developing cerebellum to medulloblastoma. Now, Chin Chiang, Ph.D., and colleagues demonstrate that “turning on” Sonic […]

Open House Slated for TPSR

Thursday, May 24th, 2012

The Translational Pathology Shared Resource (TPSR) has opened an expanded laboratory on the first floor of Medical Center North, room S-1310. To celebrate the grand opening of the newly renovated space, TPSR is hosting an open house on Wednesday, May 30, from 1-3 p.m. Vanderbilt faculty and staff are invited to tour the new space, […]

New Drug Mutes More Melanomas

Thursday, April 26th, 2012

Therapies targeted to a specific mutation in the BRAF gene can significantly reduce tumor burden in metastatic melanoma. But these therapies are not suitable for melanomas lacking the mutation, and even tumors carrying the BRAF mutation eventually become resistant to those therapies. Using human melanoma tumors implanted into mice, Ann Richmond, Ph.D., and colleagues assessed […]

Free Screening for Head and Neck Cancer

Friday, April 20th, 2012

The symptoms of head and neck cancer can be subtle, so to help catch the disease in its earliest stages the Tennessee Chapter of the Head and Neck Cancer Alliance, Vanderbilt-Ingram Cancer Center, the Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Meharry Medical College and the VA Tennessee Valley Healthcare System will offer […]