News: PGE-M

Urine Biomarker for Colon Cancer?

Friday, March 2nd, 2012

About half of colorectal tumors express elevated levels of COX-2, the key enzyme responsible for generating prostaglandins that promote cancer development. Prostaglandin E2 (PGE2) is likely the primary mediator of most of COX-2’s tumor-promoting effects, and the PGE2 metabolite, PGE-M, can be measured noninvasively in urine. To assess the utility of PGE-M as a biomarker […]