News: PloS ONE

Ancestry Impacts Smoking Risk for Lungs

Wednesday, August 8th, 2012

Smoking tobacco reduces lung function. African Americans have lower lung function compared to European Americans, but it is unclear if African ancestry modifies smoking’s impact on lung function. Melinda Aldrich, Ph.D., MPH, assistant professor of Thoracic Surgery, and colleagues evaluated lung function, tobacco smoking exposure and genetic ancestry in a large population of African Americans who […]

On the Hunt for Bladder Cancer Factors

Thursday, July 26th, 2012

Nearly 15,000 people in the United States die each year from metastatic bladder cancer. Signaling pathways that cause bladder tumor recurrence and spread are not clear. David DeGraff, Ph.D., a post-doctoral fellow in Urologic Surgery, and a multi-disciplinary team of colleagues including basic scientists, clinical pathologists and urologic surgeons, examined the role of the transcription […]

Roots of Childhood Brain Tumors

Wednesday, June 13th, 2012

Identifying the cellular origins of medulloblastoma – the most common malignant brain tumor in children – may help focus treatment on cell types responsible for tumor initiation. Previous research has linked Sonic hedgehog signaling in neuronal cell precursors within the developing cerebellum to medulloblastoma. Now, Chin Chiang, Ph.D., and colleagues demonstrate that “turning on” Sonic […]

Virus-linked Cancer Gets Help from Host

Friday, December 16th, 2011

Although viruses like HPV (human papilloma virus) are involved in a considerable number of cancers, it takes more than the viral infection for cancer to develop. Host proteins also play important roles. Mary Zutter, M.D., and colleagues are exploring the role of integrins – proteins that help cells attach to each other – in cancer […]

Magnesium Affects Prostate Cancer Risk

Friday, June 3rd, 2011

Several studies suggest that calcium intake or higher blood calcium increases prostate cancer risk; however, others do not agree. Magnesium plays an important role in counteracting the effect of calcium, including effects on cell proliferation and inflammation. Qi Dai, M.D., Ph.D., Jay Fowke, Ph.D., and colleagues investigated the importance of serum magnesium and calcium levels […]