News: Proceedings of the National Academy of Sciences

‘Detangler’ Binds, Bends and Cuts DNA

Friday, March 2nd, 2012

When the double-stranded “rope” of DNA is unwound to be copied, it can become knotted or tangled. The enzyme topoisomerase II detangles DNA by cutting both strands, removing the tangles, and stitching the DNA back together. Because breaks in the DNA can lead to genetic mutations and cell death, topoisomerase II is a target of […]

Enzyme Overlap Generates New Signals

Friday, May 13th, 2011

Two newly discovered lipid signaling molecules may have roles at sites of inflammation, Claus Schneider, Ph.D., and colleagues report in the April 26 Proceedings of the National Academy of Sciences. The enzymes COX-2 and 5-LOX initiate the production of prostaglandins and leukotrienes, respectively – lipid compounds that have inflammatory and immune system-regulatory effects in both […]

Cancer Gene’s Role in Outcomes Prediction

Friday, March 25th, 2011

A new study by Vanderbilt-Ingram Cancer Center investigators reveals that a gene signature may be useful in predicting outcomes for patients with rhabdomyosarcoma, a form of cancer most commonly diagnosed in children. The study, carried out by first author Jennifer Rosenbluth, Ph.D.; Jennifer Pietenpol, Ph.D., professor of Biochemistry, Cancer Biology and Otolaryngology and director of […]