Individuals who are outside the “normal” range of expression for the APC gene have an increased risk of colorectal cancer, according to a study published in the January issue of Gastroenterology. Mutations in the APC (adenomatous polyposis coli) gene – and variations in the expression of the gene’s two copies (allele-specific expression) — are associated [...]
News: rectal cancer
Identifying the molecular pathways that lead normal colon cells to become cancer cell could provide much needed biomarkers and therapeutic targets. Previously, Punita Dhawan, Ph.D., and colleagues showed that claudin-1 – a protein member of “tight junctions” that help bind cells together into an organized tissue structure – was greatly increased and mislocalized in colorectal [...]
As program coordinator for the Vanderbilt Hereditary Colorectal Cancer Registry, Duveen Sturgeon, R.N., regularly meets with patients and their families in the hospital to discuss the importance of being tested for the disease, which can be carried genetically to other family members. But not everyone in the family is always available, particularly those who live [...]
What is Colon/Rectal Cancer? Colorectal cancer begins in the colon or rectum and can be referred as colon or rectal cancer depending upon where the cancer starts. Colon and rectal cancer have many commonalities, but they tend to be treated differently. In order to understand colorectal cancer, it helps to be familiar with the structure [...]
In the VUMC Courtyard Café, Clay and Christa Bare discuss their risk for colon cancer with Steven Klintworth, center, research coordinator for the Department of Colon and Rectal Surgery. Klintworth volunteered to dress like a colon polyp to kick off Colon Cancer Awareness Month in March.
Just as the color pink is associated with breast cancer, blue is now linked to colon cancer awareness, and Friday, March 4, is this year’s Dress in Blue Day. The annual event is celebrated the first Friday of March, which is National Colorectal Cancer Awareness Month. “Colon cancer is the second-leading cause of cancer death [...]