Vanderbilt-Ingram Cancer Center

Mitosis, the process by which chromosomes are separated during cell division, requires tight regulation of the string-like structures (microtubules) that originate at the cell poles, attach to chromosomes, and pull them apart. Kif18A, a motor protein involved in properly aligning chromosomes for mitosis, accumulates at the “plus”-ends of microtubules – the dynamic ends that attach [...]

When the United States declared a “War on Cancer” 40 years ago, the endeavor was envisioned as a strategic battle, with doctors and researchers employing overwhelming force and lethal technology in a straightforward march to victory against a disease that claimed millions of lives. Scientists have made progress in the ensuing years, yet the enemy [...]