News: Zhongming Zhao

Network Approach Yields Glioblastoma Clues

Friday, August 10th, 2012

MicroRNAs (miRNAs) play key roles in cellular development, differentiation and cancer growth by regulating gene expression. They may be clinically useful as biomarkers and as targets for new drugs to treat such cancers as glioblastoma multiforme, the most common and lethal primary brain tumor in humans. But first scientists must understand better how the actions […]

Uncommon BRAF Melanoma Mutation

Wednesday, July 18th, 2012

An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to MEK inhibitor drugs, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation. The new study by co-first-authors Kimberly Brown Dahlman, Ph.D., Junfeng Xia, Ph.D., and Katherine Hutchinson, B.S., Vanderbilt-Ingram Cancer Center […]

Gene Database to Aid Disease Research

Wednesday, June 13th, 2012

Next generation sequencing (NGS) has dramatically accelerated the discovery of disease-associated genetic variants. Also known as massively parallel sequencing, this technological tour de force can rapidly “read” a sequence of DNA bases (the “letters” in our genomes) in parallel, making genome sequencing feasible in the research lab. Vanderbilt researchers have developed a “catalog” of human […]