Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

Samuel E. Adunyah, Ph.D.

Professor and Chair of Cancer Biology, Meharry
VICC Member
Researcher

Contact Information:

Meharry Medical College
1005 Dr. D.B. Todd, Jr. Blvd.
Nashville, TN 37208
615-327-6345

Research Specialty:

Molecular mechanisms of signal transduction and factors which regulate cell growth and differentiation

Research Description:

Dr. Adunyah's laboratory uses human myeloid and erythroid cell lines as model systems to study the molecular mechanisms of signal transduction mediated by cytokines and growth factors which regulate cell growth and differentiation. The program includes studies on immune response processes in human monocytes, lymphocytes and NK cells.

Publications:

• Boadi, WY, Iyere, PA, Adunyah, SE In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells. J Appl Toxicol, 25(1), 82-8, 2005.
• Iyamu, EW, Adunyah, SE, Fasold, H, Horiuchi, K, Baliga, S, Ohene-Frempong, K, Turner, EA, Asakura, T Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line. Exp Hematol, 31(7), 592-600, 2003.
• Boadi, WY, Iyere, PA, Adunyah, SE Effect of quercetin and genistein on copper- and iron-induced lipid peroxidation in methyl linolenate. J Appl Toxicol, 23(5), 363-9, 2003.
• Arthur FEN, and Adunyah SE "Interleukin-17 Stimulates Total PI-3K and PDK-1-mediated Activation of Akt in Human Leukemia U937 cells." , 2002, submitted.
• Subramaniam SV, Davis W, Cooper RS, and Adunyah SE "Interleukin-17 Stimulates Total PKC Activation and Induces Differntial Expression and Translocation of Specific PKC isoforms." , 2002, submitted.
• Akomeah R, Subramaniam SV, Watson B, Franklin M, Price J, and Adunyah SE "Sodium Butyrate Induces Cleavage of Delta and Epsilon PKC Whilst Expression of Zeta PKC During Apoptosis in Human leukemia U937 cells." , 2002, submitted.
• Iyamu, WE, Adunyah, SE, Fasold, H, Horiuchi, K, Elford, HL, Asakura, T, Turner, EA Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin. Am J Hematol, 63(4), 176-83, 2000.
• Iyamu, W.E., Adunyah, S.E., Fasold, H., Horiuchi, K., Elford, H.L., Asakura, T., and Turner, E.A Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (Didox and Trimidox) in combination with treptozotocin. Amer. Jour. Hematology, 63176-183, 2000.
• Subramaniam, SV, Cooper, RS, Adunyah, SE Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem Biophys Res Commun, 262(1), 14-9, 1999.
• Subramaniam, S.V., Cooper, R.S., and Adunyah, S.E Interleukin 17 induces activation of the Jak/STAT pathway in human U937 cells. Biochem. Biophys. Res. Commun., 26244-49, 1999.
• Subramaniam, S.V., Pearson, L.L. and Adunyah, S.F Interleukin-17 induces rapid tyrosine phosphorylation and activation of Raf-1 kinase in human monocytic propointor cell in U937. Biochem. Biophys. Res. Commun., 259172-177, 1999.
• Subramaniam, SV, Pearson, LL, Adunyah, SE Interleukin-17 induces rapid tyrosine phosphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun, 259(1), 172-7, 1999.
• Rivero, JA, Adunyah, SE Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. Biochem Biophys Res Commun, 248(3), 664-8, 1998.
• Rivero J.A., and Adunyah, S.E Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. Biochem. Biophys. Res. Commun., 748664-668, 1998.
• Iyamu, EW, Adunyah, SE, Elford, HL, Fasold, H, Turner, EA Trimidox-mediated morphological changes during erythroid differentiation is associated with the stimulation of hemoglobin and F-cell production in human K562 cells. Biochem Biophys Res Commun, 247(3), 759-64, 1998.
• Iyamu EW, Adunyah SE, Elford HL, Fasold H, Turner EA Trimidox-mediated morphological changes during erythroid differentiation is associated with the stimulation of hemoglobin and F-cell production in human K562 cells. Biochem Biophys Res Commun, 247(3)759-64, 1998.
• Adunyah, SE, Wheeler, BJ, Cooper, RS Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem Biophys Res Commun, 232(3), 754-8, 1997.
• Adunyah, S.E., Wheeler, B.J., and Cooper, R.S Evidence for the involvement of Lck and MAPK in the signal transduction mechanism of IL-15. Biochem. Biophys. Res. Commun., 232754-758, 1997.
• Spencer, G.C., and Adunyah, S.E IL-11 induces rapid PKC activation and cytosolic to particulate translocation of alpha and beta PKC isoforms in human erytholeukemia K567 cells. Biochem. Biophys. Res. Commun., 232754-758, 1997.
• Spencer, GC, Adunyah, SE Interleukin-11 induces rapid PKC activation and cytosolic to particulate translocation of alpha and beta PKC isoforms in human erythroleukemia K562 cells. Biochem Biophys Res Commun, 232(1), 61-4, 1997.
• Adunyah, S.E., Ceesay, K.J., and Rivero, J. A Regulation of expression and activation of AP-1 activity by erythropoietin. Biochem. Biophys. Res. Comun. , 221213-218, 1996.
• Adunyah, SE, Ceesay, KJ, Rivero, JA Regulation of jun expression and activation of AP-1 activity by erythropoietin. Biochem Biophys Res Commun, 221(2), 213-8, 1996.
• Rivero, JA, Adunyah, SE Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells. Biochem Biophys Res Commun, 224(3), 796-801, 1996.
• Rivero, JA and Adunyah, SE "Sodium butyrate induces tyrosine phosphorylation and activation of MAPK (ERK-1) in human K562 cells." Biochem. Biophys. Res. Commun., 224213-218, 1996.
• Rivero, J.A., and Adunyah, S.E Sodium butyrate induces tyrosine phosphorylation and activation of MAPK (ERK-1) in human K562 cells. Biochem. Biophys. Res. Commun., 22213-218, 1996.
• Adunyah, S.E., Chandler, R., Barner, V.K., and Cooper, R.S Hydroxarea induces transcriptional and post-transcriptional regulation of c-jun mRNA expression in human K567 cells during erythroid differentiation. Biochimics et Biophysica Acta , 1263123-132, 1995.
• Adunyah, SE, Spencer, GC, Cooper, RS, Rivero, JA, Ceesay, K Interleukin-11 induces tyrosine phosphorylation, and c-jun and c-fos mRNA expression in human K562 and U937 cells. Ann N Y Acad Sci, 766296-9, 1995.
• Adunyah, S.E., Spencer, G.C., Cooper, R.S., et al "Interleukin-11 induces tyrosine phosphorylation, c-jun and c-fes mRNA expression in human K652 and U937 cells." Annals of New York Acad. of Sci., 766296-300, 1995.
• Adunyah, SE, Pegram, ML, Cooper, RS Interleukin-13 induces rapid tyrosine phosphorylation and activation of Raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun, 206(1), 103-11, 1995.
• Adunyah, S.E., Pegram, M.L., and Cooper, R.S Interleukin-13 induces rapid tyrosine phosphorylation and activation of Raf-1 kinases in human monocytic progenitor cell line U937. Biochem. Biophys. Res. Commun. , 206103-111, 1995.
• Adunyah, SE, Chander, R, Barner, VK, Cooper, RS, Copper, RS Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation. Biochim Biophys Acta, 1263(2), 123-32, 1995.
• Adunyah, SE Granulocyte-macrophage colony stimulating factor stimulates rapid phosphorylation of proteins on tyrosines in human U937 and HL-60 leukemic cells. Biochem Biophys Res Commun, 193(3), 890-6, 1993.
• Adunyah, S.E Granulocyte-macrophage colony stimulating factor stimulates rapid phosphorylation of proteins on tryosines in human U937 and HL-60 leukemia cells. Biochem. Biophys. Res. Commun., 193890-896, 1993.
• Adunyah, S.E., Unlap, T., Franklin, C.C., and Kraft, A.S Induction of differentiation and c-jun expression by okadaic acid, a protein phosphate inhibitor, in U937 cells. J. Cellular Physio., 151415-426, 1992.
• Adunyah, SE, Unlap, TM, Franklin, CC, Kraft, AS Induction of differentiation and c-jun expression in human leukemic cells by okadaic acid, an inhibitor of protein phosphatases. J Cell Physiol, 151(2), 415-26, 1992.
• Adunyah, SE, Unlap, TM, Wagner, F, Kraft, AS Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor. J Biol Chem, 266(9), 5670-5, 1991.
• Adunyah, S.E., Unlap, T., Wagner, F., and Kraft, A.S Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony stimulating factor. J. Biol. Chem. , 2665670-5675, 1991.
• Dean, W.L., and Adunyah, S.E "Effects of cAMP-dependent and C-type kinase on platelet Ca2+-transport. Cell Calcium Metabolism Part 1 (Gary Fiksum, Editor)." Plenum Press, N.Y., 83-90, 1989.
• Adunyah, SE, Jones, LR, Dean, WL Structural and functional comparison of a 22 kDa protein from internal human platelet membranes with cardiac phospholamban. Biochim Biophys Acta, 941(1), 63-70, 1988.
• Adunyah, S.E., Jones, R.L., and Dean, W.L "Structural and functional comparison of a 22kDa protein from human platelet membrane with cardiac phospholamban." Biochem. Biophys. Acta., 94163-70, 1988.
• Adunyah, SE, Dean, WL Regulation of human platelet membrane Ca2+ transport by cAMP- and calmodulin-dependent phosphorylation. Biochim Biophys Acta, 930(3), 401-9, 1987.
• Adunyah, S.E., and Dena, W.L "Regulation of human platelet membrane Ca2+-Transport by cAMP and Ca2+/calmodulin-dependent phosphorylation." Biochem. Biophys. Acta , 930401-409, 1987.
• Adunyah, SE, Dean, WL Ca2+ transport in human platelet membranes. Kinetics of active transport and passive release. J Biol Chem, 261(7), 3122-7, 1986.
• Adunyah, S.E., and Dean, W.L "Ca2+-Transport in human platelet membranes; kinetics of active transport and release." J. Biol. Chem., 2613122-2127, 1986.
• Dean, WL, Adunyah, SE, Cohn, DV Calcium uptake and inositol trisphosphate-induced calcium release from parathyroid gland membranes. Bone Miner, 1(1), 59-67, 1986.
• Adunyah, SE, Dean, WL Effect of phorbol esters and diacylglycerols on calcium transport by human platelet membranes. Cell Calcium, 7(3), 193-202, 1986.
• Adunyah, S.E., and Dean, W.L "Effects of sulfhydryl reagents and guerectin on inositol triphosphate-induced Ca2+ release in human platelet membranes." J. Biol. Chem., 26113071-13105, 1986.
• Adunyah, SE, Dean, WL Effects of sulfhydryl reagents and other inhibitors on Ca2+ transport and inositol trisphosphate-induced Ca2+ release from human platelet membranes. J Biol Chem, 261(28), 13071-5, 1986.
• Adunyah, S.E., and Dean, W.L "Inositol triphosphate-induced Ca2+ release from human platelet membranes." Biochem. Biophys. Res. Commun., 1281274-1280, 1985.
• Adunyah, SE, Dean, WL Inositol triphosphate-induced Ca2+ release from human platelet membranes. Biochem Biophys Res Commun, 128(3), 1274-80, 1985.
• Vincenzi, F.F., Adunyah, S.E., Niggli, V., and Carafoli, E "Purified red blood cell Ca2+-ATPase: evidence for direct inhibition by presumed anti-calmodulin drugs in the absence of calmodulin." Cell Calcium, 3545-559, 1982.
• Niggli, V., Adunyah, W.E., Bababunmi, B.A.A, Cameron, B.E., and Carafoli, E "Sickle cell plasma membrane: Isolation and reconstitution of the Ca2+-ATPase enzyme." Cell Calcium, 3131-151, 1982.
• Niggli, V., Adunyah, S.E., and Carafoli, E "Acidic phospholipids, unsaturated fatty acid and limited proteolysis mimic the effect of calmodulin on the purified human erythrocyte Ca2+-ATPase." J. Biol. Chem., 2568588-8592, 1981.
• Niggli, V., Adunyah, S.E., Penniston, J.T., and Carafoli, E "Purified Ca2+-ATPase of human erythrocyte membrane: reconstitution and effect of calmodulin and phospholipids." J. Biol. Chem., 256395-401, 1981.