The VICC.ORG Investigator Directory

Christine Marie Eischen, Ph.D.

Associate Professor of Cancer Biology
Associate Professor of Pathology, Microbiology, and Immunology
VICC Member

Contact Information:

Vanderbilt University Medical Center
Nashville , TN 37232-2561
Fax: 615-343-7023

Research Description:

My lab investigates the genes that regulate tumor development. We study the influence tumor suppressors and oncogenes have on apoptosis, proliferation, chromosomal stability, and transformation. We have demonstrated that development to a malignancy is accelerated when there are alterations in the tumor suppressors p53 and ARF, which function to protect cells from hyperproliferative signals from oncogenes, such as Myc. Alternatively, a deficiency in the oncogene Mdm2, which normally inhibits apoptosis, results in the suppression of tumor development. Studies are underway to elucidate novel genes, microRNAs ,and pathways that regulate cellular transformation. Mouse models (knockout and transgenic mice), primary, immortal, and tumor cell cultures, retroviral gene transfer, biochemical purification, and gene chip and proteomic technologies are utilized in our investigations. Results from our studies will provide a better understanding of the genes and pathways that regulate tumorigenesis. Ultimately our studies will lead to a better understanding of cancer development, which will be used for improved therapeutic intervention strategies for human malignancies.


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