The VICC.ORG Investigator Directory

Darryl J. Bornhop, Ph.D.

Professor of Chemistry
VICC Member

Contact Information:

Vanderbilt University
5419 Stevenson
Nashville , TN 37203
Fax: 615-343-1234


Dr. Bornhop is Professor of Chemistry at Vanderbilt University and is an international expert on the development of lanthanide chelates for contrast detection of cancers.

Research Specialty:

In vivo imaging probes, high throughput chemical screening


  • S. Robertson, P.J. Sattu, D.L. Morgan, B.C. Pence and D.J. Bornhop "Staging of Colon Cancer in the DMH Sprague Dawley Rat Model using Micro-Endoscopy." In Preparation for Gastroenterology, .
  • M.P. Houlne, F. Koch, T.S. Goebel and D.J. Bornhop "Structure Dependent Spectroscopic Properties of Europium and Terbium Chelate Complexes Used in Biomedical Imaging and Analysis." For submission to J. American Chemical Society, .
  • N.G. Deane, H.C. Manning, C.A. Foutch, M. Kay Washington, B.A. Aronow, D.J. Bornhop and R.J. Coffey "Molecular Imaging of Spontaneous Colonic Tumors in Smad3 Null Mice." Submitted to Cancer Research, September 2005.
  • D.A. Markov, J.C. Latham, A. Kussrow, H.S. Sørensen, and Darryl J. Bornhop "Label-free, Free Solution Molecular Interaction Determinations by Interferometry." For submission to Science, March 2006.
  • H.C. Manning, J.M.M. Griffin, T.S. Goebel, B. Bell, M. Motamedi, G.E. Kiefer and D.J. Bornhop "Lanthanide Chelates for Optical Imaging in Medicine." Submitted to J. American Chemical Society, August 2005.
  • J.C. Latham, D.A. Markov, H.S. Sørensen, and D.J. Bornhop "Photobiotin Surface Chemistry Improves Label-Free Interferometric Sensing of Biochemical Interactions." Angewandte Chemie International Edition, 45(6), 955-958, 2006.
  • Latham, JC, Markov, DA, Sørensen, HS, Bornhop, DJ Photobiotin surface chemistry improves label-free interferometric sensing of biochemical interactions. Angew Chem Int Ed Engl, 45(6), 955-8, 2006.
  • L. Smentek, B. A. Hess, Jr., J. P. Cross, H.C. Manning and D.J. Bornhop "Density Function Theory Structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for Ions Across the Lanthanide Series." J. Chemical Physics, 123244302, 2005.
  • Smentek, L, Andes Hess, B, Cross, JP, Charles Manning, H, Bornhop, DJ Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. J Chem Phys, 123(24), 244302, 2005.
  • Z. Wang and D.J. Bornhop, “Z. Wang and D.J. Bornhop "Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter Volume Refractive Index Detection with Gradient Compensation." Analytical Chemistry, 777872-7877, 2005.
  • Wang, Z, Bornhop, DJ Dual-capillary backscatter interferometry for high-sensitivity nanoliter-volume refractive index detection with density gradient compensation. Anal Chem, 77(24), 7872-7, 2005.
  • H.C. Manning, B. Anderson, L. Samuelson, S. Havaland and D.J. Bornhop "Expeditious Synthesis of P-protected Macrocycles In-route to Lanthanide Chelate Metal Complexes." Teterahedron Letters, 46(28), 4707-710, 2005.
  • H.C. Manning, J.M.M. Griffin, T.S. Goebel, M. A. Wegiel, R.C. Thompson, R.R. Price and D.J. Bornhop "A PBR Targeted Molecular Imaging Agent for Cellular-Scale Bi-modal Imaging." Bioconjugate Chemistry, 151488-1495, 2004.
  • D. Markov, K. Swinney, and D.J. Bornhop "Label-Free Molecular Interaction Determinations with Nanoscale Interferometry." J. American Chemical Society, 12616659-16664, 2004.
  • Markov, DA, Swinney, K, Bornhop, DJ Label-free molecular interaction determinations with nanoscale interferometry. J Am Chem Soc, 126(50), 16659-64, 2004.
  • D.A. Markov, S. Dotson, S. Wood, and D.J. Bornhop "Non-Invasive Fluid Flow Measurements in Microfluidic Channels with Backscatter Interferometry." Electrophoresis, 25(21-22), 3805-3809, 2004.
  • X. Wang, G. Ku, M.A. Wegiel, D.J. Bornhop, G. Stoica and L.V. Wang "Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent." Optics Letters, 29(7), 730-732, 2004.
  • Markov, DA, Dotson, S, Wood, S, Bornhop, DJ Noninvasive fluid flow measurements in microfluidic channels with backscatter interferometry. Electrophoresis, 25(21-22), 3805-9, 2004.
  • Manning, HC, Goebel, T, Thompson, RC, Price, RR, Lee, H, Bornhop, DJ Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug Chem, 15(6), 1488-95, 2004.
  • H.S. Sørensen, H Pranov, N.B. Larsen, D.J. Bornhop and P.E. Andersen "Absolute Refractive Index Determination by Micro-Interfermometric Backscatter Detection." Analytical Chemistry, 75(8), 1946-1953, 2003.
  • Z. Wang, K. Swinney and D.J. Bornhop "Attomole Sensitivity for Proteins and Polypeptides with On-chip CE and Universal Detection by Interferometric Backscatter." Electrophoresis, 24865-873, 2003.
  • T.S. Goebel, J.M.M. Griffin, B. Bell, M. Motamedi, and D.J. Bornhop "Lanthanide Chelate Contrast Agents for the Detection of Malignant Lesions in the Syrian Hamster Cheek Pouch." Applied Spectroscopy, 57(10), 1216-1222, 2003.
  • H.C. Manning, A.M. Skwierawska, J.N. Marx and D.J. Bornhop "Rapid Removal of Benzyloxycarbonyl Groups from 1,4,7,10-Tetraazacyclodododecance Derivatives by Catalytic Transfer Hydrogenation." Synthetic Communications, 33(3), 457-461, 2003.
  • D. Markov, K. Norville, D. Lu, K. Swinney and D.J. Bornhop "A Fourier Analysis Approach for Capillary Polarimetry." Electrophoresis, 23(5), 809-812, 2002.
  • D. Markov and D.J. Bornhop "Breaking the 10-7 for RI Measurements in Nanoliter Volumes." Analytical Chemistry, 74(20), 5438-5441, 2002.
  • H.C. Manning, T. Goebel, J.N. Marx and D.J. Bornhop "Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Ligand Analogue." Organic Letters, 4(7), 1075-1078, 2002.
  • K. Swinney J. Nodorft and D.J. Bornhop "Nanoliter Volume Polarimetry." Applied Spectroscopy, 56(1), 134-138, 2002.
  • K. Swinney and D.J. Bornhop "Quantification and Evaluation of Joule Heating in On-Chip CE." Electrophoresis, 23(4), 621-625, 2002.
  • D.J. Bornhop, C.H. Contag, K. Licha and C.J. Murphy "Advances in Contrast Agents, Reporters and Detection." J. Biomedical Optics, 6106-110, 2001.
  • K. Swinney J. Nodorft and D.J. Bornhop "Capillary-Scale Polarimetry for Flowing Streams." Analyst, 126673-675. (Published on the Web as an Advance Article), 2001.
  • D. Markov and D.J. Bornhop "Nanoliter-scale Non-invasive Flow-Rate Quantification using Micro-Interferometric Backscatter and Phase Detection." Fresenius’ J. Analytical Chemistry, 371234-237, 2001.
  • K. Swinney and D.J. Bornhop "Non-Invasive Picoliter Volume Thermometry Based on Backscatter Interferometry." Electrophoresis, 222032-2036, 2001.
  • J.M.M. Griffin, A.M. Skwierawska, H.C. Manning, J.N. Marx and D.J. Bornhop "Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates." Tetrahedron Letters, 423823-3828, 2001.
  • K. Swinney and D.J. Bornhop "A Chip-Scale Universal Detector for Electrophoresis Based on Backscattering Interferometry." Analyst, 1251713-1717, 2000.
  • K. Swinney and D.J. Bornhop "A Review of CE Detection Methodologies." CRC Critical Reviews in Analytical Chemistry, 30(1), 1-30, 2000.
  • K. Swinney, D. Markov and D.J. Bornhop "Chip-Scale Universal Detection using Backscattering Interferometry." Analytical Chemistry, 722690-2695. This was an Accelerated Article., 2000.
  • K. Swinney and D.J. Bornhop "D- Reaction Kinetics Studied in Nanoliter Volumes using a Capillary Polarimeter." Applied Spectroscopy, 541458-1469, 2000.
  • D.J. Bornhop and K. Swinney "Detection in Capillary Electrophoresis: A Review." Electrophoresis, 211239-1250, 2000.
  • K. Swinney, D. Markov and D.J. Bornhop "Ultra-Small Volume Refractive Index Detection using Micro-Interferometry." Review of Scientific Instruments, 71(7), 2684-2693, 2000.
  • 33. D.J. Bornhop, D.S. Hubbard, M.P. Houlne, C. Adair, G.E. Kiefer, B.C. Pence and D.L. Morgan "Fluorescent Tissue Site-Selective Lanthanide Chelate, Tb-PTCMB for Enhanced Imaging of Cancer." Analytical Chemistry, 712607-2615, 1999.
  • K. Swinney, J. Pennington and D.J. Bornhop "Ion Analysis by Capillary Electrophoresis using MIBD." J. Microchemical Society, 62154-163, 1999.
  • K. Swinney, J. Hankins and D.J. Bornhop "Laser-Based Capillary Polarimeter." J. Capillary Electrophoresis and Microchip Technology, 693-96, 1999.
  • M.M. Dickens, M.P. Houlne, S. Mitra and D.J. Bornhop "Method of Depixelating Micro-Endoscopic Images." Optical Engineering, 381836-1842, 1999.
  • K. Swinney, D. Markov, J. Hankins and D.J. Bornhop "Micro-Interferometric Backscatter Detection using a Diode Laser." Analytica Chimica Acta, 400. A contribution to mark the 400th Volume and a result of the Measurement for the next Millennium conference in Egmond aan Zee, The Netherlands.265-280, 1999.
  • M.P. Houlne, S.P. O’Briant, T. Goebel and D.J. Bornhop "Some Spectroscopic and Transport Properties of a Rare-Earth Chelate: Tb-PCTMP." Analyta Chimica Acta, 397267-278. Special issue on the research of the emerging leaders in analytical chemistry., 1999.
  • K. Swinney and D.J. Bornhop "Universal Detection for Capillary Electrophoresis-Using Micro-Interferometric Backscatter Detection." J. MicroColumn Separation, 11596-604, 1999.
  • K. Swinney, J. Pennington and D.J. Bornhop "Universal Detection in Capillary Electrophoresis by Micro-Interferometric Backscatter." Analyst. Accelerated article and Hot Topic paper for The Journal. , 124221-226, 1999.
  • D.S. Hubbard, M.P. Houlne, G.E. Kiefer, H.F. Janssen, C. Hacker and D.J. Bornhop "Diagnostic Imaging Using Rare-Earth Chelates." Lasers in Medical Science, 1314-21, 1998.
  • D.S. Hubbard, M.P. Houlne, G.E. Kiefer, K. McMillan and D.J. Bornhop "Imaging and Quantitation of Tissue Selective Lanthanide Chelates." Bioimaging, 663-70, 1998.
  • M.P. Houlne, D.S. Hubbard, G.E. Kiefer and D.J. Bornhop "Imaging and Quantitation of Tissue Selective Lanthanide Chelates Using an Endoscopic Fluorometer." J. Biomedical Optics, 3145-153, 1998.
  • C.K. Kenmore, S.E. Erskine and D.J. Bornhop "Refractive Index Detection in Packed Capillary HPLC by Interferometric Backscatter." J. Chromatography A, 762219-225, 1997.
  • M.P. Houlne and D.J. Bornhop "Semi-quantitative Two Dimensional Flow Transport Imaging using Micro-Endoscopic Probes." Optical Engineering, 361982-1991, 1997.
  • H. Tarigan, C.K. Kenmore, P. Neill and D.J. Bornhop "Capillary-Scale Refractive Index Detection by Interferometeric Backscatter." Analytical Chemistry, 681762-1770, 1996.
  • D.J. Bornhop and J. Hankins "Polarimetry in Capillary Dimensions." Analytical Chemistry, 681677-1684, 1996.
  • M.P. Houlne, T.S. Agent, G.F. Kiefer, K. McMillan and D.J. Bornhop "Spectroscopy Characterization and Tissue Imaging using Site-Selective Polyazacyclic Terbium (III) Chelates." Applied Spectroscopy, 10225-244, 1996.
  • D.J. Bornhop "Micro-Volume Index of Refraction Detection by Interferometric Backscatter." Applied Optics, 343234-3239, 1995.
  • M. Hackett, H. Wang, G.C. Miller and D.J. Bornhop "Rapid Scanning UV-Vis Detection for Capillary Gas Chromatography Using a Remote Flow Cell." J. Chromatography A, 695243-257, 1995.
  • D.J. Bornhop and G. Verga "Gasoline Analysis by Rapid Scanning Absorbance Detection and Capillary Gas Chromatography." TrAC, 11194-198 , 1992.
  • D.J. Bornhop, L. Hlousek, M. Hackett, H. Wang and G.C. Miller "Remote Scanning Ultraviolet Detection for Capillary Gas Chromatography." Review of Scientific Instruments, 63191, 1992.
  • A. Bruno, A. Paluis and D.J. Bornhop "Cross-Beam RI-Absorbance Detection in the UV for Capillary Electrophoresis." Applied Spectroscopy, 45462-467, 1991.
  • D.J. Bornhop and J.G. Wangsgaard "GC-UV: Capillary Gas Chromatography with Rapid Scanning Ultraviolet Detection." HRC & CC, 14344-347, 1991.
  • D.J. Bornhop, B.J. Murphy and L. Krieger-Jones "Chemiluminescence Sulfur Detection in Capillary Supercritical Fluid Chromatography." Analytical Chemistry, 61797-800, 1989.
  • B.E. Richter, D.J. Bornhop, J.T. Swanson, J.G. Wangsgaard and M.R. Anderson "Gas Chromatographic Type Detectors in SFC." J. Chromatography, 27303-308, 1989.
  • D.J. Bornhop and J.G. Wangsgaard "Optical Detection Methods in Supercritical Fluid Chromatography." J. Chromatography, 27293-302, 1989.
  • S.R. Weinberger and D.J. Bornhop "Scanning UV Detection in Capillary Supercritical Fluid Chromatography." J. Microcolumn Separations, 190-95, 1989.
  • N.J. Dovichim F. Zarrin, T.G. Nolan and D.J. Bornhop "Laser Detector for Capillary Liquid Chromatography." Spectro. Chim. Acta Part B, 43B639-649, 1988.
  • D.J. Bornhop, S.S. Schmidt, and N.L. Porter "Use of Two Stimulaneous Detectors in Capillary Supercritical SFC." J. Chromatography, 459193-200, 1988.
  • DW Later, DJ Bornhop, ED Lee, JD Henion and RC Weibolt "Detection Techniques for Capillary Supercritical Fluid Chromatography: UV, MS and FTIR." Feature Article LC-GC, 5(9), 804-816, 1987.
  • NL Porter, BE Richter, DJ Bornhop, DW Later adn FH Beyerlein "Fill Gas Effects on Reproducibility in Capillary SFC." HRC & CC, 10477-478, 1987.
  • F Zarrin, DJ Bornhop and NJ Dovichi "Laser Doppler Velocimetry for Particle Size Determination by Light Scatter within the Sheath Flow Cuvette." Analytical Chemistry, 59854-860, 1987.
  • DJ Bornhop and NJ Dovichi "Simultaneous Laser-Based Refractive Index and Absorbance Determinations Within Micrometer Diameter Capillary Tubes." Analytical Chemistry, 591632-1636, 1987.
  • DJ Bornhop and NJ Dovichi "Subnanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Capillary Liquid Chromatography." LC-GC, 5427-429, 1987.
  • TG Nolan, DJ Bornhop and NJ Dovichi "Crossed Beam Thermal-Lens detection for 0.25-mm ID Microbore Liquid Chromatography: Separation of 2,4-Dinitrophenylhydrzones." J. Chromatography, 384189-195, 1986.
  • DJ Bornhop and NJ Dovichi "Simple Nanoliter Refractive Index Detector." Analytical Chemistry, 58504-505, 1986.
  • DJ Bornhop, TG Nolan and NJ Dovichi "Sub-Nanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Microbore Liquid Chromatography: Reversed-Phase Separation of Nanogram Amounts of Sugars." J. Chromatography, 384181-187, 1986.
  • S Kapila, DJ Bornhop, SE Manahan and GL Nickell "Design of a Combined Photoionization Detector and Photoionization-Based Electron Capture Detector." J. Chromatography, 259205-210, 1983.
  • DJ Bornhop and SE Manahan "Isotope Dilution Analysis of Exchangeable Water in Coal, Coal Char and Activated Coal Char." Analytical Letters, 13(A12), 1041-1061, 1980.

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