Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

Ellen H. Fanning, Dr.rer.nat

Professor, Molecular Biology
VICC Member
Researcher

Contact Information:

Vanderbilt Biological Sciences Department
2325 Stevenson Ctr
Nashville, TN 37232
615-343-5677

Research Specialty:

DNA replication and damage repair in mammalian cells

Research Description:

Control of DNA replication is one of the key processes in the regulation of the mammalian cell cycle. Dysregulation of the cell cycle can arise at several stages, for example in the "decision" to begin DNA replication or in the proper completion of the S-phase, and is an important causative factor in a variety of human diseases, the most frequent being cancer. The long term goal of our research is to elucidate in molecular detail the mechanisms that control DNA replication in mammalian cells.

Replication of papovaviral DNA in infected cells and in cell-free reactions has proven to be an extremely useful model system toward this end. Synthesis of RNA primers is a key step in initiation of DNA replication. In the SV40 system, this step requires specific interactions among three proteins: the viral DNA helicase T antigen, and two cellular proteins, DNA polymerase-primase and replication protein A. We seek to map the protein interaction surfaces at the atomic level (cooperation with W. Chazin) and are using biochemical and genetic tools to elucidate how these interactions promote primer synthesis.

Another aspect of our research program focusses on the role of protein phosphorylation in regulating the initiation of DNA replication in a cell-free system. We have shown that phosphorylation of human DNA polymerase alpha-primase regulates its ability to synthesize RNA primers in a cell cycle-dependent manner. We are now testing the hypothesis that phosphate turnover on one of the polymerase-primase subunits responds to DNA damage/checkpoint signals.

DNA replication, repair, and recombination all require a DNA helicase activity to separate the two DNA strands and permit DNA processing. We have cloned a cDNA encoding a novel human DNA helicase that is required for the onset of chromosomal DNA replication. The function of the helicase is not known and orthologs have not been identified in lower eukaryotic genomes so far. The helicase appears in a focal pattern in the nucleus in G1, and most of it is exported to the cytoplasm in S phase. We have shown that the helicase interacts physically and functionally with DNA polymerase alpha-primase and replication protein A. Current work seeks to identify additional proteins that interact with the helicase and to elucidate its function using genetic and biochemical methods.

Mammalian chromosomes contain about 40,000 origins that direct initiation of chromosomal DNA at specific times in S phase. However, the cis-acting elements required to constitute a functional origin of DNA replication in mammalian chromosomes in vivo are not known. To address this question, we use a competitive PCR approach to assess initiation activity of a mammalian origin that has been stably integrated into ectopic sites in chromosomal DNA, as well as mutant versions of the origin. The ectopic origin is active in multiple chromosomal sites. Three essential sequence-specific elements in the origin have been identified so far. We have mapped the binding sites of initiation proteins in the functional origin and in mutant origins by chromatin immunoprecipitation. Future work will determine how initiation protein binding and chromatin structure cooperate to activate replication.

Publications:

• Warren, EM, Huang, H, Fanning, E, Chazin, WJ, Eichman, BF Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem, 284(36), 24662-72, 2009.
• Fanning, E, Zhao, K SV40 DNA replication: from the A gene to a nanomachine. Virology, 384(2), 352-9, 2009.
• Zhao, X, Madden-Fuentes, RJ, Lou, BX, Pipas, JM, Gerhardt, J, Rigell, CJ, Fanning, E Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. J Virol, 82(11), 5316-28, 2008.
• Robertson, PD, Warren, EM, Zhang, H, Friedman, DB, Lary, JW, Cole, JL, Tutter, AV, Walter, JC, Fanning, E, Eichman, BF Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem, 283(6), 3338-48, 2008.
• Weiner, BE, Huang, H, Dattilo, BM, Nilges, MJ, Fanning, E, Chazin, WJ An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. J Biol Chem, 282(46), 33444-51, 2007.
• Taneja, P, Boche, I, Hartmann, H, Nasheuer, HP, Grosse, F, Fanning, E, Weisshart, K Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication. FEBS Lett, 581(21), 3973-8, 2007.
• Taneja, P, Nasheuer, HP, Hartmann, H, Grosse, F, Fanning, E, Weisshart, K Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication. Biochem J, 407(2), 313-20, 2007.
• Fanning, E, Klimovich, V, Nager, AR A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res, 34(15), 4126-37, 2006.
• Gray, SJ, Gerhardt, J, Doerfler, W, Small, LE, Fanning, E An Origin of DNA Replication in the Promoter Region of the Human Fragile X Mental Retardation (FMR1) Gene. Mol Cell Biol, 2006.
• Bunick, CG, Miller, MR, Fuller, BE, Fanning, E, Chazin, WJ Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein. Biochemistry, 45(50), 14965-79, 2006.
• Gray, SJ, Liu, G, Altman, AL, Small, LE, Fanning, E Discrete functional elements required for initiation activity of the Chinese hamster dihydrofolate reductase origin beta at ectopic chromosomal sites. Exp Cell Res, 2006.
• Fanning, E. and J. M. Pipas "Polyomavirus DNA replication and role in disease. In: DNA Replication in Eukaryotic Cells, 2nd edition, ed. M.L. DePamphilis, Cold Spring Harbor Press, Cold Spring Harbor, N.Y., in press." , 2006.
• Olson, E, Nievera, CJ, Klimovich, V, Fanning, E, Wu, X RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem, 281(51), 39517-33, 2006.
• Valle, M., X. S. Chen, L. E. Donate, E. Fanning, and J. M. Carazo "Structural basis for the cooperative assembly of large T antigen on the origin of replication. J. Mol. Biol., in press." , 2006.
• Valle, M, Chen, XS, Donate, LE, Fanning, E, Carazo, JM Structural basis for the cooperative assembly of large T antigen on the origin of replication. J Mol Biol, 357(4), 1295-305, 2006.
• Jiang, X, Klimovich, V, Arunkumar, AI, Hysinger, EB, Wang, Y, Ott, RD, Guler, GD, Weiner, B, Chazin, WJ, Fanning, E Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J, 25(23), 5516-26, 2006.
• McIllwraith, M. J., A. Vaisman, Y. Liu, E. Fanning, R. Woodgate, and S. C. West. "Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol. Cell." 20, 783-792 , 2005.
• McIlwraith, MJ, Mcllwraith, MJ, Vaisman, A, Liu, Y, Fanning, E, Woodgate, R, West, SC Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell, 20(5), 783-92, 2005.
• Arunkumar, AI, Klimovich, V, Jiang, X, Ott, RD, Mizoue, L, Fanning, E, Chazin, WJ Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome. Nat Struct Mol Biol, 12(4), 332-9, 2005.
• Cook, VJ, Hernández-Garduño, E, Kunimoto, D, Hershfield, ES, Fanning, EA, Hoeppner, VH, Elwood, RK, FitzGerald, JM, , The lack of association between bacille Calmette-Guerin vaccination and clustering of Aboriginals with tuberculosis in western Canada. Can Respir J, 12(3), 134-8, 2005.
• Gai, D., D. Li, C. Finkielstein, R. D. Ott, P. Taneja, E. Fanning, and X. S. Chen "Insights into the oligomeric states, conformational changes and helicase activities of SV40 large tumor antigen." J. Biol. Chem. , 279(), 38952-38959, 2004.
• Wang, W., P. Brandt, M. Rossi, L. Lindsey-Boltz, V. Podust, E. Fanning, A. Sancar, and R. A. Bambara "The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease." Proc. Natl. Acad. Sci. USA, 101(), 16762-16767, 2004.
• Gu, Jinming, Xia, Xiaobo, Yan, Peijun, Liu, Hanjian, Podust, Vladimir N, Reynolds, Albert B, Fanning, Ellen Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci. Mol Biol Cell, 15(7), 3320-32, 2004.
• Altman, Amy L, Fanning, Ellen Defined sequence modules and an architectural element cooperate to promote initiation at an ectopic mammalian chromosomal replication origin. Mol Cell Biol, 24(10), 4138-50, 2004.
• Fanning, EL Evidence-based disease management: its role in cardiovascular risk reduction. Dis Manag, 7 Suppl 1S7-10, 2004.
• Fanning, EL, Selwyn, BJ, Larme, AC, DeFronzo, RA Improving efficacy of diabetes management using treatment algorithms in a mainly Hispanic population. Diabetes Care, 27(7), 1638-46, 2004.
• Gai, D, Li, D, Finkielstein, CV, Ott, RD, Taneja, P, Fanning, E, Chen, XS Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen. J Biol Chem, 279(37), 38952-9, 2004.
• Friedman, N, Fanning, EL Overweight and obesity: an overview of prevalence, clinical impact, and economic impact. Dis Manag, 7 Suppl 1S1-6, 2004.
• Weisshart, Klaus, Friedl, Sabine, Taneja, Poonam, Nasheuer, Heinz-Peter, Schlott, Bernhard, Grosse, Frank, Fanning, Ellen Partial proteolysis of SV40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly. J Biol Chem, 279(), 38943-38951, 2004.
• Wang, W, Brandt, P, Rossi, ML, Lindsey-Boltz, L, Podust, V, Fanning, E, Sancar, A, Bambara, RA The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. Proc Natl Acad Sci U S A, 101(48), 16762-7, 2004.
• Eichman, B. F. and E. Fanning "The power of pumping together: deconstructing the engine of a DNA replication machine." Cell, 1193-4, 2004.
• Eichman, BF, Fanning, E The power of pumping together; deconstructing the engine of a DNA replication machine. Cell, 119(1), 3-4, 2004.
• Aladjem, M. I., and E. Fanning "The replicon revisited: an old model learns new tricks in metazoan chromosomes." EMBO Rep., 5(), 686-691, 2004.
• Aladjem, MI, Fanning, E The replicon revisited: an old model learns new tricks in metazoan chromosomes. EMBO Rep, 5(7), 686-91, 2004.
• Skarstad, K., E. Boye, & E. Fanning "Circles in the sand: Meeting report. Chromosome replication to cell division: 40th anniversary of the replicon (cover article)." EMBO Reports, 4 661-665, 2003.
• Li, D., R. Zhao, W. Lilyestrom, D. Gai, R. Zhang, J. A. DeCaprio, E. Fanning, A. Jochimiak, G. Szakonyi, & X. S. Chen "The structure of SV40 lage T-antigen hexamer and its functional implications in cell transformation and DNA replication." Nature , 423661-665, 2003.
• Smith, S, Taylor, GD, Fanning, EA Chronic cutaneous Mycobacterium haemophilum infection acquired from coral injury. Clin Infect Dis, 37(7), e100-1, 2003.
• Skarstad, K, Boye, E, Fanning, E Circles in the sand. EMBO Rep, 4(7), 661-5, 2003.
• Li, D, Zhao, R, Lilyestrom, W, Gai, D, Zhang, R, DeCaprio, JA, Fanning, E, Jochimiak, A, Szakonyi, G, Chen, XS Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature, 423(6939), 512-8, 2003.
• Li, D., R. Zhao, W. Lilyestrom, D. Gai, R. ZKhang, J.A. DeCaprio, E. Fanning, A. Joachimiak, G. Szakonyi, and X.S. Chen "Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen." Nature, (423), 512-518, 2003.
• Taneja, Poonam, Gu, Jinming, Peng, Rui, Carrick, Ryan, Uchiumi, Fumiaki, Ott, Robert D, Gustafson, Eric, Podust, Vladimir N, Fanning, Ellen A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. J Biol Chem, 277(43), 40853-61, 2002.
• P. Taneja, J. Gu, R. Peng, R. Carrick, F. Uchiumi, R. D. Ott, E. Gustafson, V. N. Podust, & E. Fanning "A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication." J. Biol. Chem., 277 40853-40861, 2002.
• Morris, PD, Byrd, AK, Tackett, AJ, Cameron, CE, Tanega, P, Ott, R, Fanning, E, Raney, KD Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5''-biotinylated oligonucleotides but not from 3''-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA. Biochemistry, 41(7), 2372-8, 2002.
• Altman, A. L., & E. Fanning "Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication." Chemtracts-Biochemistry and Molecular Biology, 15374-379, 2002.
• Ott, Robert D, Wang, Yingda, Fanning, Ellen Mutational analysis of simian virus 40 T-antigen primosome activities in viral DNA replication. J Virol, 76(10), 5121-30, 2002.
• R. D. Ott, Y. Wang, & E. Fanning "Mutational analysis of simian virus 40 T-antigen primosome activities in viral DNA replication." J. Virol., 76(10), 5121-5130, 2002.
• Morris, P. D., A. K. Byrd, A. J. Tackett, C. E. Cameron, E. Fanning, P. Taneja, R. D. Ott, & K. D. Raney "NS3 helicase and SV40 T antigen helicase displace streptavidin from 5-biotinylated oligonucleotides but not from 3-biotinylated oligonucleotides." Biochemistry, 41 (), 2372-2378, 2002.
• Podust, V. N., L.-S. Chang, R. Ott, G. L. Dianov, & E. Fanning "Reconstitution of four-subunit DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme." J. Biol. Chem, 2773894-3901, 2002.
• Podust, Vladimir N, Chang, Long-Sheng, Ott, Robert, Dianov, Grigory L, Fanning, Ellen Reconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme. J Biol Chem, 277(6), 3894-901, 2002.
• R. D. Ott, C. Rehfuess, V. N. Podust, J. E. Clark & E. Fanning "Role of the p68 subunit of human DNA polymerase alpha-primase in simian virus 40 DNA replication." Mol. Cell. Biol. , 225669-5678, 2002.
• Ott, Robert D, Rehfuess, Christoph, Podust, Vladimir N, Clark, Jill E, Fanning, Ellen Role of the p68 subunit of human DNA polymerase alpha-primase in simian virus 40 DNA replication. Mol Cell Biol, 22(16), 5669-78, 2002.
• Plitt, SS, Soskolne, CL, Fanning, EA, Newman, SC Prevalence and determinants of tuberculin reactivity among physicians in Edmonton, Canada: 1996-1997. Int J Epidemiol, 30(5), 1022-8, 2001.
• Altman, A. L., Fanning, E "The Chinese hamster DHFR replication origin beta is active at multiple ectopic chromosomal locations and requires specific elements for activity." Mol. Cell. Biol, 211098-1110, 2001.
• Altman, A L, Fanning, E The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity. Mol Cell Biol, 21(4), 1098-110, 2001.
• Michael, W. M., Ott, R., Fanning, E., Newport, J "Activation of the DNA replication checkpoint through RNA synthesis by primase." Science, 2892133-2137, 2000.
• Michael, WM, Ott, R, Fanning, E, Newport, J Activation of the DNA replication checkpoint through RNA synthesis by primase. Science, 289(5487), 2133-7, 2000.
• Greenwood, CM, Fujiwara, TM, Boothroyd, LJ, Miller, MA, Frappier, D, Fanning, EA, Schurr, E, Morgan, K Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family. Am J Hum Genet, 67(2), 405-16, 2000.
• Herbig, U, Griffith, J W, Fanning, E Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells. Mol Biol Cell, 11(12), 4117-30, 2000.
• Herbig, U., Griffith, J. W., Fanning, E "Mutation of the cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells." Mol. Biol. Cell , 114117-4130, 2000.
• Voitenleitner, C., Rehfuess, C. Hilmes, M., O'Rear, L., Liao, P. C., Gage, D. A. Ott, R. , Nasheuer, H.-P., Fanning, E "Cell cycle-dependent regulation of DNA polymerase a- primase activity by phosphorylation." Mol. Cell. Biol, 19646-656, 1999.
• Voitenleitner, C, Rehfuess, C, Hilmes, M, O'Rear, L, Liao, P C, Gage, D A, Ott, R, Nasheuer, H P, Fanning, E Cell cycle-dependent regulation of human DNA polymerase alpha-primase activity by phosphorylation. Mol Cell Biol, 19(1), 646-56, 1999.
• Kolpashchikov, D. M., K. Weisshart, H.-P. Nasheuer, S. N. Khodyreva, E. Fanning, A. Favre, & O. I. Lavrik "Interaction of the p70 subunit of RPA with a DNA template direct p32 to the -end of nascent DNA." FEBS Lett., 450131-134, 1999.
• Kolpashchikov, DM, Weisshart, K, Nasheuer, HP, Khodyreva, SN, Fanning, E, Favre, A, Lavrik, OI Interaction of the p70 subunit of RPA with a DNA template directs p32 to the 3''-end of nascent DNA. FEBS Lett, 450(1-2), 131-4, 1999.
• Herbig, U., K.Weisshart, P. Taneja & E. Fanning "Interaction of the transcription factor TFIID with SV40 large T antigen interferes with replication of SV40 DNA in vitro." J. Virol., 731009-1107, 1999.
• Herbig, U, Weisshart, K, Taneja, P, Fanning, E Interaction of the transcription factor TFIID with simian virus 40 (SV40) large T antigen interferes with replication of SV40 DNA in vitro. J Virol, 73(2), 1099-107, 1999.
• Nation, PN, Fanning, EA, Hopf, HB, Church, TL Observations on animal and human health during the outbreak of Mycobacterium bovis in game farm wapiti in Alberta. Can Vet J, 40(2), 113-7, 1999.
• Vassetzky, YS, Tchang, F, Fanning, E, Méchali, M T-antigen interactions with chromatin and p53 during the cell cycle in extracts from xenopus eggs. J Cell Biochem, 75(2), 288-99, 1999.
• Herbig, U., Marlar, C.A., Fanning, E "The Cdc6 nucleotide binding site regulates its activity in DNA replication in human cells." Mol. Biol. Cell, 102631-2645, 1999.
• Herbig, U, Marlar, C A, Fanning, E The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. Mol Biol Cell, 10(8), 2631-45, 1999.
• Starzinski-Powitz, A, Gaetje, R, Zeitvogel, A, Kotzian, S, Handrow-Metzmacher, H, Herrmann, G, Fanning, E, Baumann, R Tracing cellular and molecular mechanisms involved in endometriosis. Hum Reprod Update, 4(5), 724-9, 1999.
• Weisshart, K., Taneja, P., Jenne, A., Herbig, U., Simmons, D. T., Fanning, E "Two regions of SV40 T antigen determine cooperativity of double hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding." J. Virol, 732201-2211, 1999.
• Weisshart, K., P. Taneja, A. Jenne, U. Herbig, D. T. Simmons, & E. Fanning "Two regions of SV40 T antigen determine cooperativity of double hexamer assembly on the viral origin of DNA replication and p53 during the cell cycle in extracts from Xenopus eggs." J. Cell Biochem, 75288-289, 1999.
• Weisshart, K, Taneja, P, Jenne, A, Herbig, U, Simmons, DT, Fanning, E Two regions of simian virus 40 T antigen determine cooperativity of double-hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding. J Virol, 73(3), 2201-11, 1999.
• Huang, S.G. , Weisshart, K., & Fanning, E "Characterization of the nucleotide binding properties of SV40 T antigen using fluorescent 3? (2?)-0-(2, 4,6-trinitorphenyl) adenine nucleotide analogues." Biochemistry, 3715336-15344, 1998.
• Huang, SG, Weisshart, K, Fanning, E Characterization of the nucleotide binding properties of SV40 T antigen using fluorescent 3''(2'')-O-(2,4,6-trinitrophenyl)adenine nucleotide analogues. Biochemistry, 37(44), 15336-44, 1998.
• Podust, V.N., Tiwari, N., Ott, R., & Fanning, E "Functional interactions among the subunits of replication factor C potentiate and modulate its ATPase activity." J. Biol. Chem, 27312935-12942, 1998.
• Podust, V N, Tiwari, N, Ott, R, Fanning, E Functional interactions among the subunits of replication factor C potentiate and modulate its ATPase activity. J Biol Chem, 273(21), 12935-42, 1998.
• Fanning, EA Globalization of tuberculosis. CMAJ, 158(5), 611-2, 1998.
• Fanning, E "Introduction to simian virus 40 (SV40): Getting by with more than a little help from its host cell." Dev. Biol. Stand. 94, eds. F. Brown, A.M. Lewis, Basel, Karger, 3-8, 1998.
• Fanning, E Introduction to simian virus 40: getting by with more than a little help from its host cell. Dev Biol Stand, 943-8, 1998.
• Fourie, PB, Becker, PJ, Festenstein, F, Migliori, GB, Alcaide, J, Antunes, M, Auregan, G, Beyers, N, Carvalho, JM, Cruz, JR, Fanning, EA, Gie, R, Huong, ND, Leitch, AG Procedures for developing a simple scoring method based on unsophisticated criteria for screening children for tuberculosis. Int J Tuberc Lung Dis, 2(2), 116-23, 1998.
• Podust, V. N., Tiwari, N., Stephan, S., Fanning, E "Replication factor C disengages from PCNA upon sliding clamp formation and PCNA itself tethers DNA polymerase d to DNA." J. Biol. Chem, 27331992-31999, 1998.
• Podust, V N, Tiwari, N, Stephan, S, Fanning, E Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA. J Biol Chem, 273(48), 31992-9, 1998.
• Huang, S.G., Weisshart, K., Gilbert, I., & Fanning, E "Stoichiometry and mechanism of assembly of SV40 T antigen complexes wiht the viral origin of DNA replication and DNA polymerase a-primase." Biochemistry , 3715345-15352, 1998.
• Huang, SG, Weisshart, K, Gilbert, I, Fanning, E Stoichiometry and mechanism of assembly of SV40 T antigen complexes with the viral origin of DNA replication and DNA polymerase alpha-primase. Biochemistry, 37(44), 15345-52, 1998.
• Weisshart, K., Taneja, P., Fanning, E "The RPA binding site in SV40 T antigen and its role in the early steps of viral DNA replication." J. Virol, 729771-9781, 1998.
• Weisshart, K, Taneja, P, Fanning, E The replication protein A binding site in simian virus 40 (SV40) T antigen and its role in the initial steps of SV40 DNA replication. J Virol, 72(12), 9771-81, 1998.
• Starzinski-Powitz, A., R. Gaetje, A. Zeitvogel, S. Kotzian, H. Handrow-Metzmacher, G. Herrmann, E. Fanning, & R. Baumann "Tracing cellular and molecular mechanisms involved in endometriosis." Hum. Reprod. Update, 4724-729, 1998.
• Manns, BJ, Fanning, EA, Cowie, RL Antituberculosis drug resistance in immigrants to Alberta, Canada, with tuberculosis, 1982-1994. Int J Tuberc Lung Dis, 1(3), 225-30, 1997.
• Podust, V N, Fanning, E Assembly of functional replication factor C expressed using recombinant baculoviruses. J Biol Chem, 272(10), 6303-10, 1997.
• Podust, V.N., & Fanning, E. "Assembly of functional replication factor C expressed using recombinant baculovirusesAssembly of functional replication factor C expressed using recombinant baculoviruses." J. Biol. Chem., 2726303-6310, 1997.
• Boche, I. & Fanning, E "Nucleocytoplasmic recycling of the nuclear localization signal receptor a subunit in vivo is dependent on a nuclear export signal, energy and RCC1." J. Cell Biol, 139313-325, 1997.
• Boche, I, Fanning, E Nucleocytoplasmic recycling of the nuclear localization signal receptor alpha subunit in vivo is dependent on a nuclear export signal, energy, and RCC1. J Cell Biol, 139(2), 313-25, 1997.
• Voitenleitner, C., Fanning, E., & Nasheuer, H.- "Phosphorylation of DNA polymerase ?-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro." Oncogene, 141611-1616, 1997.
• Voitenleitner, C, Fanning, E, Nasheuer, HP Phosphorylation of DNA polymerase alpha-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro. Oncogene, 14(13), 1611-5, 1997.
• Smith, MT, Fanning, EW Report on the workshop entitled: "Modeling chemically induced leukemia--implications for benzene risk assessment. Leuk Res, 21(5), 361-74, 1997.
• Weisshart, K., Bradley, M.K., Weiner, B.M., Schneider, C,, Moarefi, I., Fanning, E. & Arthur, A.K "An N-terminal deletion mutant of SV40 large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase." , 1996.
• Weisshart, K., Bradley, M.K., Weiner, B.M., Schneider, C., Moarefi, I., Fanning, E. & Arthur, A.K "An N-terminal deletion mutant of SV40 large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase ? and replicate SV40 DNA in vitro." J. Virol, 703509-3516, 1996.
• Weisshart, K, Bradley, MK, Weiner, BM, Schneider, C, Moarefi, I, Fanning, E, Arthur, AK An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro. J Virol, 70(6), 3509-16, 1996.
• Zlotkin, T., Kaufmann, G., Jiang, Y., Lee, M.Y.W.T., Uitto, L., Syvaoja, J., Dornreiter, I., Fanning, E., & Nethanel, T. "DNA polymerase epsilon may be dispensable for SV 40- but not cellular DNA replication." EMBO J., 152298-2305, 1996.
• Zlotkin, T, Kaufmann, G, Jiang, Y, Lee, MY, Uitto, L, Syväoja, J, Dornreiter, I, Fanning, E, Nethanel, T DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication. EMBO J, 15(9), 2298-305, 1996.
• Marshallsay, C., Dickmanns, A., Bischoff, F. R., Ponstingl, H., Fanning, E. & Luhrmann, R "In vitro and in vivo evidence that protein and U1snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCCI." Nucl. Acids Res, 241829-1836, 1996.
• Marshallsay, C, Dickmanns, A, Bischoff, FR, Ponstingl, H, Fanning, E, Lührmann, R In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1. Nucleic Acids Res, 24(10), 1829-36, 1996.
• Berger, L.C., Smith, D.B., Davidson, I., Fanning, E., & Wildeman, A.G "Interaction between T antigen and TEA domain of the factor TEF-1 derepresses the SV40 late promoter in vitro: identification of T antigen domains important for transcription control." J. Virol, 701203-1212, 1996.
• Berger, LC, Smith, DB, Davidson, I, Hwang, JJ, Fanning, E, Wildeman, AG Interaction between T antigen and TEA domain of the factor TEF-1 derepresses simian virus 40 late promoter in vitro: identification of T-antigen domains important for transcription control. J Virol, 70(2), 1203-12, 1996.
• Weisshart, K.. & Fanning, E "Roles of protein phosphorylation in the control of DNA replication." DNA Replication in Eukaryotic Cells, ed. M.L. DePamphilis, Cold Spring Harbor Press, 295-330, 1996.
• Stadlbauer, F., Voitenleitner, C., Bruckner, A., Fanning E., & Nasheuer, H.-P "Species specific replication of SV40 DNA in vitro requires the pl 80 subunit of human DNA polymerase." , 1996.
• Stadlbauer, F, Voitenleitner, C, Brückner, A, Fanning, E, Nasheuer, HP Species-specific replication of simian virus 40 DNA in vitro requires the p180 subunit of human DNA polymerase alpha-primase. Mol Cell Biol, 16(1), 94-104, 1996.
• Dickmanns, A., Bischoff, F.R., Marshallsay, C., Luhrmann, R., Ponstingl, H.. & Fanning "The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or -GDP, but not by RanQ69L or RanT24N." J. Cell Sci, 1091449-1457, 1996.
• Dickmanns, A, Bischoff, F R, Marshallsay, C, Lührmann, R, Ponstingl, H, Fanning, E The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N. J Cell Sci, 109 ( Pt 6)1449-57, 1996.
• Pantel, K., Dickmanns, A., Zippelius, A., Klein, C., Hoechtlen-Vollmer, W., Schlimok, G.,Weckermann, D., Oberneder, R., Fanning, E., & Riethmuller, G "Establishment of carcinoma cell lines from bone marrow of patients with minimal residual cancer- a novel source of tumor cell vaccine s." J. Natl Cancer Inst, 871162-1168, 1995.
• Pantel, K, Dickmanns, A, Zippelius, A, Klein, C, Shi, J, Hoechtlen-Vollmar, W, Schlimok, G, Weckermann, D, Oberneder, R, Fanning, E Establishment of micrometastatic carcinoma cell lines: a novel source of tumor cell vaccines. J Natl Cancer Inst, 87(15), 1162-8, 1995.
• Fanning, EA, Menzies, R Surveillance of medical students for TB urged. CMAJ, 152(3), 327-8, 1995.
• Brückner, A, Stadlbauer, F, Guarino, LA, Brunahl, A, Schneider, C, Rehfuess, C, Previes, C, Fanning, E, Nasheuer, HP The mouse DNA polymerase alpha-primase subunit p48 mediates species-specific replication of polyomavirus DNA in vitro. Mol Cell Biol, 15(3), 1716-24, 1995.
• Fanning, E Control of SV40 DNA replication by protein phosphorylation: a model for cellular DNA replication. Trends Cell Biol, 4(7), 250-5, 1994.
• Warner, ML, Moore, LE, Smith, MT, Kalman, DA, Fanning, E, Smith, AH Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada. Cancer Epidemiol Biomarkers Prev, 3(7), 583-90, 1994.
• Fischer, U, Heinrich, J, van Zee, K, Fanning, E, Lührmann, R Nuclear transport of U1 snRNP in somatic cells: differences in signal requirement compared with Xenopus laevis oocytes. J Cell Biol, 125(5), 971-80, 1994.
• Hermeking, H, Wolf, DA, Kohlhuber, F, Dickmanns, A, Billaud, M, Fanning, E, Eick, D Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts. Proc Natl Acad Sci U S A, 91(22), 10412-6, 1994.
• Schneider, C, Weisshart, K, Guarino, LA, Dornreiter, I, Fanning, E Species-specific functional interactions of DNA polymerase alpha-primase with simian virus 40 (SV40) T antigen require SV40 origin DNA. Mol Cell Biol, 14(5), 3176-85, 1994.
• Cegielska, A, Moarefi, I, Fanning, E, Virshup, DM T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. J Virol, 68(1), 269-75, 1994.
• Dickmanns, A, Zeitvogel, A, Simmersbach, F, Weber, R, Arthur, AK, Dehde, S, Wildeman, AG, Fanning, E The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen. J Virol, 68(9), 5496-508, 1994.
• van Zee, K, Dickmanns, A, Fischer, U, Lührmann, R, Fanning, E A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA. J Cell Biol, 121(2), 229-40, 1993.
• Heath, CV, Fanning, E, Cole, CN Adenovirus helper function activity of simian virus 40 T antigen mutants. Virology, 189(2), 762-5, 1992.
• Dornreiter, I, Erdile, LF, Gilbert, IU, von Winkler, D, Kelly, TJ, Fanning, E Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen. EMBO J, 11(2), 769-76, 1992.
• Dobbelstein, M, Arthur, AK, Dehde, S, van Zee, K, Dickmanns, A, Fanning, E Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells. Oncogene, 7(5), 837-47, 1992.
• Henkel, T, Zabel, U, van Zee, K, Müller, JM, Fanning, E, Baeuerle, PA Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell, 68(6), 1121-33, 1992.
• Machin, GA, Honoré, LH, Fanning, EA, Molesky, M Perinatally acquired neonatal tuberculosis: report of two cases. Pediatr Pathol, 12(5), 707-16, 1992.
• Nasheuer, HP, von Winkler, D, Schneider, C, Dornreiter, I, Gilbert, I, Fanning, E Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system. Chromosoma, 102(1 Suppl), S52-9, 1992.
• Fanning, E Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J Virol, 66(3), 1289-93, 1992.
• Fanning, E, Knippers, R Structure and function of simian virus 40 large tumor antigen. Annu Rev Biochem, 6155-85, 1992.
• Macarthur, C, Enarson, DA, Fanning, EA, Hessel, PA, Newman, S Tuberculosis among institutionalized elderly in Alberta, Canada. Int J Epidemiol, 21(6), 1175-9, 1992.
• van Zee, K, Appel, F, Fanning, E A hydrophobic protein sequence can override a nuclear localization signal independently of protein context. Mol Cell Biol, 11(10), 5137-46, 1991.
• Scheidtmann, KH, Buck, M, Schneider, J, Kalderon, D, Fanning, E, Smith, AE Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino- and carboxy-terminal domains. J Virol, 65(3), 1479-90, 1991.
• Kohiyama, M, Hughes, P, Fanning, E Slaloms on the double helix. Workshop on Regulatory Mechanisms of DNA Replication, sponsored by the Human Frontier Science Program, Les Arcs, France, March 17-23, 1991. New Biol, 3(7), 656-9, 1991.
• Höss, A, Moarefi, I, Scheidtmann, KH, Cisek, LJ, Corden, JL, Dornreiter, I, Arthur, AK, Fanning, E Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector. J Virol, 64(10), 4799-807, 1990.
• Miedzinski, LJ, Callaghan, JC, Fanning, EA, Gelfand, ET, Goldsand, G, Modry, D, Penkoske, P, Preiksaitis, J, Sheehan, G, Sterns, L Antimicrobial prophylaxis for open heart operations. Ann Thorac Surg, 50(5), 800-7, 1990.
• Enarson, DA, Fanning, EA, Allen, EA Case-finding in the elimination phase of tuberculosis: high risk groups in epidemiology and clinical practice. Bull Int Union Tuberc Lung Dis, 65(2-3), 73-4, 1990.
• Hille, MB, Dholakia, JN, Wahba, A, Fanning, E, Stimler, L, Xu, Z, Yablonka-Reuveni, Z In-vivo and in-vitro evidence supporting co-regulation of translation in sea-urchin eggs by polypeptide initiation factors, pH optimization, and mRNAs. J Reprod Fertil Suppl, 42235-48, 1990.
• Dornreiter, I, Höss, A, Arthur, AK, Fanning, E SV40 T antigen binds directly to the large subunit of purified DNA polymerase alpha. EMBO J, 9(10), 3329-36, 1990.
• Montano, X, Millikan, R, Milhaven, JM, Newsom, DA, Ludlow, JW, Arthur, AK, Fanning, E, Bikel, I, Livingston, DM Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function. Proc Natl Acad Sci U S A, 87(19), 7448-52, 1990.
• Höss, A, Moarefi, IF, Fanning, E, Arthur, AK The finger domain of simian virus 40 large T antigen controls DNA-binding specificity. J Virol, 64(12), 6291-6, 1990.
• Hartl, M, Willnow, T, Fanning, E cis-active elements from mouse chromosomal DNA suppress simian virus 40 DNA replication. J Virol, 64(6), 2884-94, 1990.
• Lee, GF, Fanning, EW, Small, MP, Hille, MB Developmentally regulated proteolytic processing of a yolk glycoprotein complex in embryos of the sea urchin, Strongylocentrotus purpuratus. Cell Differ Dev, 26(1), 5-17, 1989.
• Fanning, E, Schneider, J, Arthur, A, Höss, A, Moarefi, I, Modrow, S Structure and function of SV 40 large T antigen: communication between functional domains. Curr Top Microbiol Immunol, 1449-19, 1989.
• Schneider, J, Schindewolf, C, van Zee, K, Fanning, E A mutant SV40 large T antigen interferes with nuclear localization of a heterologous protein. Cell, 54(1), 117-25, 1988.
• Arthur, AK, Höss, A, Fanning, E Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids. J Virol, 62(6), 1999-2006, 1988.
• Schneider, J, Fanning, E Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity. J Virol, 62(5), 1598-605, 1988.
• Alliger, P, Traut, W, Carstens, E, Fanning, E Partial purification and characterization of a cellular protein that binds to the SV40 core origin of DNA replication. Biochim Biophys Acta, 951(2-3), 396-402, 1988.
• Traut, W, Fanning, E Sequence-specific interactions between a cellular DNA-binding protein and the simian virus 40 origin of DNA replication. Mol Cell Biol, 8(2), 903-11, 1988.
• Gill, MJ, Fanning, EA, Chomyc, S Childhood lymphadenitis in a harsh northern climate due to atypical mycobacteria. Scand J Infect Dis, 19(1), 77-83, 1987.
• Runzler, R, Thompson, S, Fanning, E Oligomerization and origin DNA-binding activity of simian virus 40 large T antigen. J Virol, 61(7), 2076-83, 1987.
• Hinzpeter, M, Fanning, E, Deppert, W A new sensitive target-bound DNA binding assay for SV40 large T antigen. Virology, 148(1), 159-67, 1986.
• Vogt, B, Vakalopoulou, E, Fanning, E Allosteric control of simian virus 40 T-antigen binding to viral origin DNA. J Virol, 58(3), 765-72, 1986.
• Ryder, K, Silver, S, DeLucia, AL, Fanning, E, Tegtmeyer, P An altered DNA conformation in origin region I is a determinant for the binding of SV40 large T antigen. Cell, 44(5), 719-25, 1986.
• Taylor, GD, Fanning, EA, Ferguson, JP, Jewell, LD, Sekhon, AS Disseminated histoplasmosis in a nonendemic area. CMAJ, 133(8), 763-5, 1985.
• Matz, B, Schlehofer, JR, Zur Hausen, H, Huber, B, Fanning, E HSV- and chemical carcinogen-induced amplification of SV40 DNA sequences in transformed cells is cell-line-dependent. Int J Cancer, 35(4), 521-5, 1985.
• Huber, B, Vakalopoulou, E, Burger, C, Fanning, E Identification and biochemical analysis of DNA replication-defective large T antigens from SV40-transformed cells. Virology, 146(2), 188-202, 1985.
• Ryder, K, Vakalopoulou, E, Mertz, R, Mastrangelo, I, Hough, P, Tegtmeyer, P, Fanning, E Seventeen base pairs of region I encode a novel tripartite binding signal for SV40 T antigen. Cell, 42(2), 539-48, 1985.
• Fanning, E, Burger, C, Huber, B, Markau, U, Sperka, S, Thompson, S, Vakalopoulou, E, Vogt, B How does SV40 T antigen control initiation of viral DNA replication. Adv Exp Med Biol, 179241-8, 1984.
• Burger, C, Fanning, E Specific DNA binding activity of T antigen subclasses varies among different SV40-transformed cell lines. Virology, 126(1), 19-31, 1983.
• Fanning, E, Westphal, KH, Brauer, D, Cörlin, D Subclasses of simian virus 40 large T antigen: differential binding of two subclasses of T antigen from productively infected cells to viral and cellular DNA. EMBO J, 1(9), 1023-8, 1982.
• Dorn, A, Brauer, D, Otto, B, Fanning, E, Knippers, R Subclasses of simian-virus-40 large tumor antigen. Partial purification and DNA-binding properties of two subclasses of tumor antigen from productively infected cells. Eur J Biochem, 128(1), 53-62, 1982.
• Fanning, EA Sugar in breakfast cereals. Aust Dent J, 27(2), 134, 1982.
• Fanning, E, Burger, C, Gurney, EG Comparison of T antigen-associated host phosphoproteins from SV40-infected and -transformed cells of different species. J Gen Virol, 55(Pt 2), 367-78, 1981.
• Fanning, E, Nowak, B, Burger, C Detection and characterization of multiple forms of simian virus 40 large T antigen. J Virol, 37(1), 92-102, 1981.
• Gurling, FG, Fanning, EA, Leppard, PI Handicapped children: behavioural and co-ordination characteristics affecting the delivery of dental care. Aust Dent J, 25(4), 201-4, 1980.
• Klempnauer, KH, Fanning, E, Otto, B, Knippers, R Maturation of newly replicated chromatin of simian virus 40 and its host cell. J Mol Biol, 136(4), 359-74, 1980.
• Fanning, E, Baumgartner, I Role of fast-sedimenting SV40 nucleoprotein complexes in virus assembly. Virology, 102(1), 1-12, 1980.
• Fanning, EA, Cellier, KM, Somerville, CM South Australian kindergarten children: effects of fluoride tablets and fluoridated water on dental caries in primary teeth. Aust Dent J, 25(5), 259-63, 1980.
• Otto, B, Fanning, E, Richter, A DNA polymerases and a single-strand-specific DNA-binding protein associated with simian virus 40 nucleoprotein complexes. Cold Spring Harb Symp Quant Biol, 43 Pt 2705-8, 1979.
• Baumgartner, I, Kuhn, C, Fanning, E Identification and characterization of fast-sedimenting SV40 nucleoprotein complexes. Virology, 96(1), 54-63, 1979.
• Fanning, EA Nutrition in childhood: the role of the dentist. Aust Dent J, 24(5), 352-7, 1979.
• Gurling, FG, Fanning, EA, Leppard, PI The dental care of handicapped children in South Australia. Aust Dent J, 24(3), 178-81, 1979.
• Otto, B, Fanning, E DNA polymerase alpha is associated with replicating SV40 nucleoprotein complexes. Nucleic Acids Res, 5(5), 1715-28, 1978.
• Fanning, EA Nutrition in childhood: long-term effects on general and dental health. Australas Nurses J, 8(2), 19-20, 1978.
• Fanning, E, Schick, J, Doerfler, W Studies on the occurrence of high molecular weight adenovirus type 2 DNA in productively infected cells. Virology, 88(1), 186-90, 1978.
• Tjia, S, Fanning, E, Schick, J, Doerfler, W Incomplete particles of adenovirus type 2. III. Viral and cellular DNA sequences in incomplete particles. Virology, 76(1), 365-79, 1977.
• Fanning, E, Doerfler, W Intracellular forms of adenovirus DNA. VI. Quantitation and characterization of the four size-classes of adenovirus type 2 DNA in human KB cells. Virology, 81(2), 433-48, 1977.
• Gurling, FG, Fanning, EA, Leppard, PI The handicapped child population in South Australia in 1975. Aust Dent J, 22(2), 107-12, 1977.
• Fanning, E, Doerfler, W Intracellular forms of adenovirus DNA. V. Viral DNA sequences in hamster cells abortively infected and transformed with human adenovirus type 12. J Virol, 20(2), 373-83, 1976.
• Schick, J, Baczko, K, Fanning, E, Groneberg, J, Burger, H, Doerfler, W Intracellular forms of adenovirus DNA: integrated form of adenovirus DNA appears early in productive infection. Proc Natl Acad Sci U S A, 73(4), 1043-7, 1976.
• Beyreuther, K, Adler, K, Fanning, E, Murray, C, Klemm, A, Geisler, N Amino-acid sequence of lac repressor from Escherichia coli. Isolation, sequence analysis and sequence assembly of tryptic peptides and cyanogen-bromide fragments. Eur J Biochem, 59(2), 491-509, 1975.
• Doerfler, W, Burger, H, Ortin, J, Fanning, E, Brown, DT, Mestphal, M, Winterhoff, U, Weiser, B, Schick, J Integration of adenovirus DNA into the cellular genome. Cold Spring Harb Symp Quant Biol, 39 Pt 1505-21, 1975.
• Fanning, EA, Leppard, PI Oral hygiene home care kits: effects on the dental behaviour of kindergarten children. Aust Dent J, 20(1), 39-42, 1975.
• Fanning, EA, Somerville, CM South Australian kindergarten children: dental health factors in urban and country families. Australas Nurses J, 4(4), 3, 19, 1975.
• Fanning, EA, Cellier, KM, Leadbeater, MM, Somerville, CM South Australian kindergarten children: fluoride tablet supplements and dental caries. Aust Dent J, 20(1), 7-9, 1975.
• Fanning, E, Doerfler, W Proceedings: Characterization of the integrated form of adenovirus DNA by reassociation kinetics. Hoppe Seylers Z Physiol Chem, 355(10), 1191, 1974.
• Fanning, EA, Somerville, CM South Australian kindergarten children: dental health factors in urban and country families. Aust Dent J, 19(1), 35-8, 1974.
• Fanning, EA, Leppard, PI A survey of university students in South Australia. Part 3. Attitudes to dental treatment. Aust Dent J, 18(1), 20-2, 1973.
• Fanning, EA Dental problems in the young child. Australas Nurses J, 2(23), 2, 1973.
• Clarke, NG, Fanning, EA Further consideration of the effects of calcium sucrose phosphate on dental plaque: a telemetric study. Aust Dent J, 18(4), 229-32, 1973.
• Fanning, EA The medical and chemical aspects of water fluoridation. Australas Nurses J, 2(22), 3, 1973.
• Fanning, EA, Leppard, PI A dental survey of university students in South Australia. Aust Dent J, 17(5), 363-72, 1972.
• Adler, K, Beyreuther, K, Fanning, E, Geisler, N, Gronenborn, B, Klemm, A, Müller-Hill, B, Pfahl, M, Schmitz, A How lac repressor binds to DNA. Nature, 237(5354), 322-7, 1972.
• Borja, CR, Fanning, E, Huang, IY, Bergdoll, MS Purification and some physicochemical properties of staphylococcal enterotoxin E. J Biol Chem, 247(8), 2456-63, 1972.
• Fanning, EA University of Adelaide Dental students: sociological aspects and oral health status. Med J Aust, 2(11), 615-6, 1972.
• Fanning, EA An exercise in preventive dentistry. Aust Dent J, 16(3), 172-4, 1971.
• Smithies, O, Gibson, DM, Fanning, EM, Percy, ME, Parr, DM, Connell, GE Deletions in immunoglobulin polypeptide chains as evidence for breakage and repair in DNA. Science, 172(983), 574-7, 1971.
• Clarke, NG, Graf, H, Fanning, EA Fluoride ion release from dentifrices and caries inhibition in a clinical trial. Aust Dent J, 16(4), 249-51, 1971.
• Clarke, NG, Fanning, EA Plaque pH and calcium sucrose phosphate: a telemetric study. Aust Dent J, 16(1), 13-6, 1971.
• Fanning, EA, Brown, T Primary and permanent tooth development. Aust Dent J, 16(1), 41-3, 1971.
• Smithies, O, Gibson, D, Fanning, EM, Goodfliesh, RM, Gilman, JG, Ballantyne, DL Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac. Biochemistry, 10(26), 4912-21, 1971.
• Fanning, EA, Cellier, KM, Gotjamanos, T, Vowles, NJ The effect of fluoride dentifrices on the caries incidence of individual tooth surfaces. Aust Dent J, 16(5), 287-90, 1971.
• Fanning, EA The needs of the community--dental health. Australas Nurses J, 5(20), 10-1 passim, 1971.
• Fanning, EA, Moorrees, CF A comparison of permanent mandibular molar formation in Australian aborigines and Caucasoids. Arch Oral Biol, 14(9), 999-1006, 1969.
• Fanning, EA, Gotjamanos, T, Vowles, NJ Dental caries in children related to availability of sweets at school canteens. Med J Aust, 1(22), 1131-2, 1969.
• Fanning, EA, Gotjamanos, T, Vowles, NJ Dental health and treatment requirements of South Australian secondary schoolchildren. Med J Aust, 2(18), 899-901, 1969.
• Henning, FR, Fanning, EA Instruction in oral hygiene. Aust Dent J, 13(1), 40-5, 1968.
• Cellier, KM, Fanning, EA, Gotjamanos, T, Vowles, NJ Some statistical aspects of a clinical study on dental caries in children. Arch Oral Biol, 13(5), 483-508, 1968.
• Fanning, EA, Gotjamanos, T, Vowles, NH, van der Wielen, I The effects of fluoride dentifrices on the incidence and distribution of stained tooth surfaces in children. Arch Oral Biol, 13(4), 467-9, 1968.
• Fanning, EA, Gotjamanos, T, Vowles, NJ The use of fluoride dentifrices in the control of dental caries: methodology and results of a clinical trial. Aust Dent J, 13(3), 201-6, 1968.
• Fanning, EA, Gotjamanos, T, Vowles, NJ, Cellier, KM, Simmons, DW The use of fluoride dentifrices in the control of dental caries: a preliminary report of a clinical trial. Med J Aust, 1(8), 383-5, 1967.
• Fanning, EA, Henning, FR Toothbrush design and its relation to oral health. Aust Dent J, 12(5), 464-7, 1967.
• Henning, FR, Fanning, EA Toothbrushing habits in a group of Australian dental patients. Aust Dent J, 12(3), 274-6, 1967.
• Fanning, EA, Barrett, MJ An acute dental health problem: a study at a maternity hospital. Med J Aust, 2(14), 643-4, 1966.
• BARRETT, MJ, BROWN, T, FANNING, EA A LONG-TERM STUDY OF THE DENTAL AND CRANIOFACIAL CHARACTERISTICS OF A TRIBE OF CENTRAL AUSTRALIAN ABORIGINES. Aust Dent J, 1063-8, 1965.
• MOORREES, CF, FANNING, EA, HUNT, EE AGE VARIATION OF FORMATION STAGES FOR TEN PERMANENT TEETH. J Dent Res, 421490-502, 1963.
• MOORREES, CF, FANNING, EA, HUNT, EE FORMATION AND RESORPTION OF THREE DECIDUOUS TEETH IN CHILDREN. Am J Phys Anthropol, 21205-13, 1963.