Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

Joseph M. Amann, Ph.D.

Research Assistant Professor of Cancer Biology
Researcher

Contact Information:

Vanderbilt-Ingram Cancer Center
2220 Pierce Ave , PRB 771
Nashvill, TN 37232-6840
615-936-3822

Publications:

• Yang, L, Amann, JM, Kikuchi, T, Porta, R, Guix, M, Gonzalez, A, Park, K, Billheimer, D, Arteaga, CL, Tai, H, DuBois, R, Carbone, DP, Johnson, DH. "Inhibition of EGFR signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer." In press, 2007.
• Amann, JM, Chaurand, P, Gonzalez, A, Mobley, JA, Massion, PP, Carbone, DP, Caprioli, RM Selective profiling of proteins in lung cancer cells from fine-needle aspirates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Cancer Res, 12(17), 5142-50, 2006.
• Amann, J, Kalyankrishna, S, Massion, PP, Ohm, JE, Girard, L, Shigematsu, H, Peyton, M, Juroske, D, Huang, Y, Stuart Salmon, J, Kim, YH, Pollack, JR, Yanagisawa, K, Gazdar, A, Minna, JD, Kurie, JM, Carbone, DP Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res, 65(1), 226-35, 2005.
• Amann, JM, Chyla, BJ, Ellis, TC, Martinez, A, Moore, AC, Franklin, JL, McGhee, L, Meyers, S, Ohm, JE, Luce, KS, Ouelette, AJ, Washington, MK, Thompson, MA, King, D, Gautam, S, Coffey, RJ, Whitehead, RH, Hiebert, SW Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol, 25(21), 9576-85, 2005.
• Hiebert, SW, Reed-Inderbitzin, EF, Amann, J, Irvin, B, Durst, K, Linggi, B The t(8;21) fusion protein contacts co-repressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor. Blood Cells Mol Dis, 30(2), 177-83, 2003.
• Amann, JM, Nip, J, Strom, DK, Lutterbach, B, Harada, H, Lenny, N, Downing, JR, Meyers, S, Hiebert, SW ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol, 21(19), 6470-83, 2001.
• Heibert, SW, Lutterbach, B, Durst, K, Wang, L, Linggi, B, Wu, S, Wood, L, Amann, J, King, D, Hou, Y Mechanisms of transcriptional repression by the t(8;21)-, t(12;21)-, and inv(16)-encoded fusion proteins. Cancer Chemother Pharmacol, 48 Suppl 1S31-4, 2001.
• Hiebert, SW, Lutterbach, B, Amann, J Role of co-repressors in transcriptional repression mediated by the t(8;21), t(16;21), t(12;21), and inv(16) fusion proteins. Curr Opin Hematol, 8(4), 197-200, 2001.
• Fenrick, R, Wang, L, Nip, J, Amann, JM, Rooney, RJ, Walker-Daniels, J, Crawford, HC, Hulboy, DL, Kinch, MS, Matrisian, LM, Hiebert, SW TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. Mol Cell Biol, 20(16), 5828-39, 2000.
• Fenrick, R, Amann, JM, Lutterbach, B, Wang, L, Westendorf, JJ, Downing, JR, Hiebert, SW Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol, 19(10), 6566-74, 1999.
• Amann, J, Kidd, VJ, Lahti, JM Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. J Biol Chem, 272(6), 3823-32, 1997.
• Amann, J, Valentine, M, Kidd, VJ, Lahti, JM Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA. Genomics, 32(2), 260-5, 1996.
• Lahti, JM, Valentine, M, Xiang, J, Jones, B, Amann, J, Grenet, J, Richmond, G, Look, AT, Kidd, VJ Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nat Genet, 7(3), 370-5, 1994.
• Ball, LA, Amann, JM, Garrett, BK Replication of nodamura virus after transfection of viral RNA into mammalian cells in culture. J Virol, 66(4), 2326-34, 1992.