Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

L. Jackson Roberts, M.D.

Prof Pharmacology & Med
VICC Member
Researcher

Contact Information:

Vanderbilt University Medical Center
522 Robinson Research Building
Nashville, TN 37232-6602
615-322-3203

Research Specialty:

Role of Free Radicals and Oxidative Injury in Human Disease

Research Description:

Free radicals primarily derived from oxygen have been implicated in a wide variety of diseases ranging from atherosclerosis, cancer, neurodegenerative diseases, and even the normal aging process. Free radicals readily attack lipids, proteins, and DNA resulting in mutations and deleterious effects on membrane and protein structure and function.

We discovered a series of novel products of free radical attack on lipids termed isoprostanes. Measurement of isoprostanes has emerged as the most reliable approach to assess free radical reactions in vivo. They also exert potent biological activities, which are currently being characterized. We have also discovered a series of similar compounds (neuroprostanes) formed by free radical attack on a unique lipid in the brain. Their role in neurodegenerative diseases is currently under investigation. Recently, we discovered novel highly reactive molecules that are produced by these pathways. These molecules rapidly adduct to proteins and we are currently exploring the pathobiological consequences of their formation in neurodegenerative and other diseases. More recently, we discovered new products of lipid peroxidation called isofurans whose formation is uniquely regulated by oxygen tension. Measurement of isofurans provides a unique tool to assess the role of oxidative injury in the setting of hyperoxia and in disorders of mitochondrial dysfunction. This provides ample opportunities for scientific investigation in a multidisciplinary area of research that is highly relevant to human disease. .

Publications:

• Przybysz, AJ, Choe, KP, Roberts, LJ, Strange, K Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mech Ageing Dev, 130(6), 357-69, 2009.
• Roberts, LJ, Milne, GL Isoprostanes. J Lipid Res, 50 SupplS219-23, 2009.
• Roberts, LJ, II "In Memoriam: Jason D. Morrow, MD (1957-2008)." Free Rad Biol Med, 451203-1205, 2008.
• Roberts, LJ Inhibition of heme protein redox cycling: reduction of ferryl heme by iron chelators and the role of a novel through-protein electron transfer pathway. Free Radic Biol Med, 44(3), 257-60, 2008.
• Powers JS, Roberts LJ 2nd, Tarvin E, Hongu N, Choi L, Buchowski M "Oxidative stress and multi-organ failure in hospitalized elderly people." J Am Geriatr Soc, 56(6), 1150-2, 2008.
• Patel M, Liang LP, Hou H, Williams BB, Kmiec M, Swartz HM, Fessel JP, Roberts LJ 2nd. "Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension." J Neurochem, 104(1), 264-70, 2008.
• Guo Z, Ran Q, Roberts LJ 2nd, Zhou L, Richardson A, Sharan C, Wu D, Yang H "Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice." Free Radic Biol Med, 44(3), 343-52, 2008.
• Hartert, TV, Deng, X, Hartman, TJ, Wen, W, Yang, G, Gao, YT, Jin, M, Bai, C, Gross, M, Roberts, LJ, Sheller, JR, Christman, J, Dupont, W, Griffin, M, Shu, XO The Shanghai Women''s Asthma and Allergy Study: objectives, design, and recruitment results. Am J Epidemiol, 167(11), 1387-96, 2008.
• Han ES, Muller FL, Perez V, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A "The in vivo gene expression signature of oxidative stress." Physiol Genomics, 34(1), 112-26, 2008.
• Frisard, MI, Broussard, A, Davies, SS, Roberts, LJ, Rood, J, de Jonge, L, Fang, X, Jazwinski, SM, Deutsch, WA, Ravussin, E, , Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study. J Gerontol A Biol Sci Med Sci, 62(7), 752-9, 2007.
• Wu, P, Roberts, LJ, Shintani, AK, Sheller, JR, Minton, PA, Higgins, SB, Hartert, TV Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations. Free Radic Res, 41(9), 956-62, 2007.
• Ivester, P, Roberts, LJ, Young, T, Stafforini, D, Vivian, J, Lees, C, Young, J, Daunais, J, Friedman, D, Rippe, RA, Parsons, CJ, Grant, KA, Cunningham, C Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcohol Clin Exp Res, 31(1), 144-55, 2007.
• Montuschi, P, Barnes, P, Roberts, LJ Insights into oxidative stress: the isoprostanes. Curr Med Chem, 14(6), 703-17, 2007.
• Davies, SS, Amarnath, V, Brame, CJ, Boutaud, O, Roberts, LJ Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc, 2(9), 2079-91, 2007.
• Arneson, KO, Roberts, LJ Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. Methods Enzymol, 433127-43, 2007.
• Boyden, PA, Davies, SS, Viswanathan, PC, Amarnath, V, Balser, JR, Roberts, LJ Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias. J Cardiovasc Pharmacol, 50(5), 480-6, 2007.
• Roberts, LJ, Oates, JA, Linton, MF, Fazio, S, Meador, BP, Gross, MD, Shyr, Y, Morrow, JD The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med, 43(10), 1388-93, 2007.
• Jakupcak, M, Roberts, LJ, Martell, C, Mulick, P, Michael, S, Reed, R, Balsam, KF, Yoshimoto, D, McFall, M A pilot study of behavioral activation for veterans with posttraumatic stress disorder. J Trauma Stress, 19(3), 387-91, 2006.
• Muller, FL, Song, W, Liu, Y, Chaudhuri, A, Pieke-Dahl, S, Strong, R, Huang, TT, Epstein, CJ, Roberts, LJ, Csete, M, Faulkner, JA, Van Remmen, H Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med, 40(11), 1993-2004, 2006.
• Cotton, RB, Hazinski, TA, Morrow, JD, Roberts, LJ, Zeldin, DC, Lindstrom, DP, Lappalainen, U, Law, AB, Steele, S Cimetidine does not prevent lung injury in newborn premature infants. Pediatr Res, 59(6), 795-800, 2006.
• Roberts, LJ, Cleland, LG, Thomas, R, Proudman, SM Early combination disease modifying antirheumatic drug treatment for rheumatoid arthritis. Med J Aust, 184(3), 122-5, 2006.
• Cotton, RB, Sundell, HW, Zeldin, DC, Morrow, JD, Roberts, LJ, Hazinski, TA, Law, AB, Steele, S Inhaled nitric oxide attenuates hyperoxic lung injury in lambs. Pediatr Res, 59(1), 142-6, 2006.
• Gustafson, EJ, Roberts, LJ, Leefers, LA Linking linear programming and spatial simulation models to predict landscape effects of forest management alternatives. J Environ Manage, 81(4), 339-50, 2006.
• Talati, M, Meyrick, B, Peebles, RS, Davies, SS, Dworski, R, Mernaugh, R, Mitchell, D, Boothby, M, Roberts, LJ, Sheller, JR Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med, 40(7), 1210-9, 2006.
• Davies, SS, Brantley, EJ, Voziyan, PA, Amarnath, V, Zagol-Ikapitte, I, Boutaud, O, Hudson, BG, Oates, JA, Roberts, LJ Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry, 45(51), 15756-67, 2006.
• Davies, SS, Zackert, W, Luo, Y, Cunningham, CC, Frisard, M, Roberts, LJ Quantification of dinor,dihydro metabolites of F(2)-isoprostanes in urine by liquid chromatography/tandem mass spectrometry. Anal Biochem, 348(2), 185-91, 2006.
• Stafforini, DM, Sheller, JR, Blackwell, TS, Sapirstein, A, Yull, FE, McIntyre, TM, Bonventre, JV, Prescott, SM, Roberts, LJ Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem, 281(8), 4616-23, 2006.
• Dutta, UK, Lane, J, Roberts, LJ, Majid, DS Superoxide formation and interaction with nitric oxide modulate systemic arterial pressure and renal function in salt-depleted dogs. Exp Biol Med (Maywood), 231(3), 269-76, 2006.
• Montgomery-Downs, HE, Krishna, J, Roberts, LJ, Gozal, D Urinary F(2)-isoprostane metabolite levels in children with sleep-disordered breathing. Sleep Breath, 10(4), 211-5, 2006.
• Gaut, JP, Belaaouaj, A, Byun, J, Roberts, LJ, Maeda, N, Frei, B, Heinecke, JW Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic Biol Med, 40(9), 1494-501, 2006.
• Kadiiska, MB, Gladen, BC, Baird, DD, Germolec, D, Graham, LB, Parker, CE, Nyska, A, Wachsman, JT, Ames, BN, Basu, S, Brot, N, Fitzgerald, GA, Floyd, RA, George, M, Heinecke, JW, Hatch, GE, Hensley, K, Lawson, JA, Marnett, LJ, Morrow, JD, Murray, DM, Plastaras, J, Roberts, LJ, Rokach, J, Shigenaga, MK, Sohal, RS, Sun, J, Tice, RR, Van Thiel, DH, Wellner, D, Walter, PB, Tomer, KB, Mason, RP, Barrett, JC Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning. Free Radic Biol Med, 38(6), 698-710, 2005.
• Kadiiska, MB, Gladen, BC, Baird, DD, Graham, LB, Parker, CE, Ames, BN, Basu, S, Fitzgerald, GA, Lawson, JA, Marnett, LJ, Morrow, JD, Murray, DM, Plastaras, J, Roberts, LJ, Rokach, J, Shigenaga, MK, Sun, J, Walter, PB, Tomer, KB, Barrett, JC, Mason, RP Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med, 38(6), 711-8, 2005.
• Roberts, LJ, Huffam, SE, Walton, SF, Currie, BJ Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J Infect, 50(5), 375-81, 2005.
• Canter, JA, Eshaghian, A, Fessel, J, Summar, ML, Roberts, LJ, Morrow, JD, Sligh, JE, Haines, JL Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation. Free Radic Biol Med, 38(5), 678-83, 2005.
• Ward, WF, Qi, W, Van Remmen, H, Zackert, WE, Roberts, LJ, Richardson, A Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci, 60(7), 847-51, 2005.
• Shibao, C, Arzubiaga, C, Roberts, LJ, Raj, S, Black, B, Harris, P, Biaggioni, I Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension, 45(3), 385-90, 2005.
• Idris, AH, Roberts, LJ, Caruso, L, Showstark, M, Layon, AJ, Becker, LB, Vanden Hoek, T, Gabrielli, A Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusion. Crit Care Med, 33(9), 2043-8, 2005.
• Fukuda, K, Davies, SS, Nakajima, T, Ong, BH, Kupershmidt, S, Fessel, J, Amarnath, V, Anderson, ME, Boyden, PA, Viswanathan, PC, Roberts, LJ, Balser, JR Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res, 97(12), 1262-9, 2005.
• Kwan, KS, Roberts, LJ, Swalm, DM Sexual dysfunction and chronic pain: the role of psychological variables and impact on quality of life. Eur J Pain, 9(6), 643-52, 2005.
• Roberts, LJ, Fessel, JP, Davies, SS The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation. Brain Pathol, 15(2), 143-8, 2005.
• Habbu, JH, Hayman, R, Roberts, LJ Tuberous sclerosis in an antenatally diagnosed cardiac rhabdomyoma. J Obstet Gynaecol, 25(2), 193-4, 2005.
• Taber, DF, Fessel, JP, Roberts, LJ A nomenclature system for isofurans. Prostaglandins Other Lipid Mediat, 73(1-2), 47-50, 2004.
• Mun-Bryce, S, Roberts, LJ, Hunt, WC, Bartolo, A, Okada, Y Acute changes in cortical excitability in the cortex contralateral to focal intracerebral hemorrhage in the swine. Brain Res, 1026(2), 218-26, 2004.
• Vorster, AA, Rebello, MT, Coutts, N, Ehrenreich, L, Gama, AD, Roberts, LJ, Goliath, R, Ramesar, R, Greenberg, LJ Arg120stop nonsense mutation in the RP2 gene: mutational hotspot and germ line mosaicism. Clin Genet, 65(1), 7-10, 2004.
• Zagol-Ikapitte, I, Bernoud-Hubac, N, Amarnath, V, Roberts, LJ, Boutaud, O, Oates, JA Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry, 43(18), 5503-10, 2004.
• Bernoud-Hubac, N, Fay, LB, Armarnath, V, Guichardant, M, Bacot, S, Davies, SS, Roberts, LJ, Lagarde, M Covalent binding of isoketals to ethanolamine phospholipids. Free Radic Biol Med, 37(10), 1604-11, 2004.
• Ilsley, JN, Belinsky, GS, Guda, K, Zhang, Q, Huang, X, Blumberg, JB, Milbury, PE, Roberts, LJ, Stevens, RG, Rosenberg, DW Dietary iron promotes azoxymethane-induced colon tumors in mice. Nutr Cancer, 49(2), 162-9, 2004.
• Friel, JK, Friesen, RW, Harding, SV, Roberts, LJ Evidence of oxidative stress in full-term healthy infants. Pediatr Res, 56(6), 878-82, 2004.
• Lim, E, Wicks, I, Roberts, LJ Intracardiac thrombosis complicating antiphospholipid antibody syndrome. Intern Med J, 34(3), 135-7, 2004.
• Davies, SS, Amarnath, V, Roberts, LJ Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway. Chem Phys Lipids, 128(1-2), 85-99, 2004.
• Hou, Xin, Roberts, L Jackson, Gobeil, Fernand, Taber, DouglasF, Kanai, Kazuo, Abran, Daniel, Brault, Sonia, Checchin, Daniella, Sennlaub, Florian, Lachapelle, Pierre, Varma, DayaR, Chemtob, Sylvain Isomer-specific contractile effects of a series of synthetic f2-isoprostanes on retinal and cerebral microvasculature. Free Radic Biol Med, 36(2), 163-72, 2004.
• Montine, KS, Quinn, JF, Zhang, J, Fessel, JP, Roberts, LJ, Morrow, JD, Montine, TJ Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids, 128(1-2), 117-24, 2004.
• Montuschi, P, Barnes, PJ, Roberts, LJ Isoprostanes: markers and mediators of oxidative stress. FASEB J, 18(15), 1791-800, 2004.
• Elso, CM, Roberts, LJ, Smyth, GK, Thomson, RJ, Baldwin, TM, Foote, SJ, Handman, E Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway. Genes Immun, 5(2), 93-100, 2004.
• Davies, SS, Talati, M, Wang, X, Mernaugh, RL, Amarnath, V, Fessel, J, Meyrick, BO, Sheller, J, Roberts, LJ Localization of isoketal adducts in vivo using a single-chain antibody. Free Radic Biol Med, 36(9), 1163-74, 2004.
• Brame, Cynthia J., Boutaud, Olivier, Davies, Sean S., Yang, Tao, Oates, John A., Roden, Dan, Roberts, L. Jackson Modifcation of proteins by isoketal-containing oxidized phospholipids. J Biol Chem, 27913447-13451, 2004.
• Roberts, LJ New drugs for rheumatoid arthritis. N Engl J Med, 351(25), 2659-61; author reply 2659-61, 2004.
• Carey, KB, Roberts, LJ, Kivlahan, DR, Carey, MP, Neal, DJ Problems assessment for substance using psychiatric patients: development and initial psychometric evaluation. Drug Alcohol Depend, 75(1), 67-77, 2004.
• Amarnath, V, Amarnath, K, Amarnath, K, Davies, S, Roberts, LJ Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls. Chem Res Toxicol, 17(3), 410-5, 2004.
• Yang, H, Roberts, LJ, Shi, MJ, Zhou, LC, Ballard, BR, Richardson, A, Guo, ZM Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res, 95(11), 1075-81, 2004.
• Wu, T, Rifai, N, Roberts, LJ, Willett, WC, Rimm, EB Stability of measurements of biomarkers of oxidative stress in blood over 36 hours. Cancer Epidemiol Biomarkers Prev, 13(8), 1399-402, 2004.
• Roberts, LJ, Fessel, JP The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Chem Phys Lipids, 128(1-2), 173-86, 2004.
• Ran, Q, Liang, H, Gu, M, Qi, W, Walter, CA, Roberts, LJ, Herman, B, Richardson, A, Van Remmen, H Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem, 279(53), 55137-46, 2004.
• Browne, SE, Roberts, LJ, Dennery, PA, Doctrow, SR, Beal, MF, Barlow, C, Levine, RL Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radic Biol Med, 36(7), 938-42, 2004.
• Jha, S, Roberts, LJ Acrania. J Obstet Gynaecol, 23(1), 78, 2003.
• Swanson, SP, Roberts, LJ, Chapman, MD Are anaesthetists prone to suicide? A review of rates and risk factors. Anaesth Intensive Care, 31(4), 434-45, 2003.
• Fortepiani, Lourdes A, Zhang, Huimin, Racusen, Lorraine, Roberts, L Jackson, Reckelhoff, Jane F Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats. Hypertension, 41(3 Pt 2), 640-5, 2003.
• Huang, Hong, He, Zhi, Roberts, L Jackson, Salahudeen, Abdulla K Deferoxamine reduces cold-ischemic renal injury in a syngeneic kidney transplant model. Am J Transplant, 3(12), 1531-7, 2003.
• Willcox, Joye K, Catignani, George L, Roberts, L Jackson Dietary flavonoids fail to suppress F(2)-isoprostane formation in vivo. Free Radic Biol Med, 34(7), 795-9, 2003.
• Ran, Qitao, Van Remmen, Holly, Gu, Mingjun, Qi, Wenbo, Roberts, L Jackson, Prolla, Tomas, Richardson, Arlan Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes. Free Radic Biol Med, 35(9), 1101-9, 2003.
• Shaner, A, Eckman, T, Roberts, LJ, Fuller, T Feasibility of a skills training approach to reduce substance dependence among individuals with schizophrenia. Psychiatr Serv, 54(9), 1287-9, 2003.
• Davies, Sean S, Ju, Won-Kyu, Neufeld, Arthur H, Abran, Daniel, Chemtob, Sylvain, Roberts, L Jackson Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. J Ocul Pharmacol Ther, 19(1), 45-54, 2003.
• Fessel, Joshua P, Hulette, Christine, Powell, Suzanne, Roberts, L Jackson, Zhang, Jing Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. J Neurochem, 85(3), 645-50, 2003.
• Boutaud, Olivier, Li, Junyu, Zagol, Irene, Shipp, Elizabeth A, Davies, Sean S, Roberts, L Jackson, Oates, John A Levuglandinyl Adducts of Proteins Are Formed via a Prostaglandin H2 Synthase-dependent Pathway after Platelet Activation. J Biol Chem, 278(19), 16926-8, 2003.
• Campbell, IK, Roberts, LJ, Wicks, IP Molecular targets in immune-mediated diseases: the case of tumour necrosis factor and rheumatoid arthritis. Immunol Cell Biol, 81(5), 354-66, 2003.
• Roberts, LJ, Thackray, M Recovery intervention to manage severe pain: comparing apples with oranges. Anaesth Intensive Care, 31(6), 699-700, 2003.
• Vanharanta, Meri, Voutilainen, Sari, Nurmi, Tarja, Kaikkonen, Jari, Roberts, L Jackson, Morrow, Jason D, Adlercreutz, Herman, Salonen, Jukka T Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation. Atherosclerosis, 160(2), 465-9, 2002.
• Roberts, L J, Khursandi, D C S Career choice influences in Australian anaesthetists. Anaesth Intensive Care, 30(3), 355-9, 2002.
• Fessel, Joshua P, Porter, Ned A, Moore, Kevin P, Sheller, James R, Roberts, L Jackson Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc Natl Acad Sci U S A, 99(26), 16713-8, 2002.
• Davies, Sean S, Amarnath, Ventkataraman, Montine, Kathleen S, Bernoud-Hubac, Nathalie, Boutaud, Olivier, Montine, Thomas J, Roberts, L Jackson Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J, 16(7), 715-7, 2002.
• Sasaki, Diane M, Yuan, Ying, Gikas, Katherine, Kanai, Kazuo, Taber, Douglass, Morrow, Jason D, Roberts, L Jackson, Callewaert, Denis M Enzyme immunoassays for 15-F2T isoprostane-M, an urinary biomarker for oxidant stress. Adv Exp Med Biol, 507537-41, 2002.
• Fam, Samuel S, Murphey, Laine J, Terry, Erin S, Zackert, William E, Chen, Yan, Gao, Ling, Pandalai, Saurabh, Milne, Ginger L, Roberts, L Jackson, Porter, Ned A, Montine, Thomas J, Morrow, Jason D Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem, 277(39), 36076-84, 2002.
• Milatovic, Dejan, Zhang, Yueli, Olson, Sandra J, Montine, Kathleen S, Roberts, L Jackson, Morrow, Jason D, Montine, Thomas J, Dermody, Terence S, Valyi-Nagy, Tibor Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes. J Neurovirol, 8(4), 295-305, 2002.
• Bernoud-Hubac, Nathalie, Roberts, L Jackson Identification of oxidized derivatives of neuroketals. Biochemistry, 41(38), 11466-71, 2002.
• Wells, N, Roberts, L, Medlin, LC Issues related to staff retention and turnover. Semin Nurse Manag, 10(3), 171-9, 2002.
• Montine, Thomas J, Neely, M Diana, Quinn, Joseph F, Beal, M Flint, Markesbery, William R, Roberts, L Jackson, Morrow, Jason D Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med, 33(5), 620-6, 2002.
• Morrow, Jason D, Roberts, L Jackson Mass spectrometric quantification of F2-isoprostanes as indicators of oxidant stress. Methods Mol Biol, 18657-66, 2002.
• Youssef, Jihan, Davis, Alan, Roberts, L Jackson, Swift, Larry L, Morrow, Jason D, Badr, Mostafa Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. Adv Exp Med Biol, 507551-5, 2002.
• Montine, Thomas J, Quinn, Joseph F, Milatovic, Dejan, Silbert, Lisa C, Dang, Theresa, Sanchez, Stephanie, Terry, Erin, Roberts, L Jackson, Kaye, Jeffrey A, Morrow, Jason D Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Ann Neurol, 52(2), 175-9, 2002.
• Ikizler, T A, Morrow, J D, Roberts, L J, Evanson, J A, Becker, B, Hakim, R M, Shyr, Y, Himmelfarb, J Plasma F2-isoprostane levels are elevated in chronic hemodialysis patients. Clin Nephrol, 58(3), 190-7, 2002.
• Jha, S, Haldar, MK, Roberts, LJ Primary ovarian pregnancy with an intrauterine contraceptive device in situ. J Obstet Gynaecol, 22(1), 104-5, 2002.
• Roberts, L Jackson, Morrow, J D Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation. Cell Mol Life Sci, 59(5), 808-20, 2002.
• Roberts, Lindy J, Finch, Phillip M, Pullan, Peter T, Bhagat, Chotoo I, Price, Leanne M Sex hormone suppression by intrathecal opioids: a prospective study. Clin J Pain, 18(3), 144-8, 2002.
• Meng, Shumei, Roberts, L Jackson, Cason, Garrick W, Curry, Travis S, Manning, R Davis Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats. Am J Physiol Regul Integr Comp Physiol, 283(3), R732-8, 2002.
• Miller, Elizabeth T, Neal, Dan J, Roberts, Lisa J, Baer, John S, Cressler, Sally O, Metrik, Jane, Marlatt, G Alan Test-retest reliability of alcohol measures: is there a difference between internet-based assessment and traditional methods?. Psychol Addict Behav, 16(1), 56-63, 2002.
• Hubatsch, Ina, Mannervik, Bengt, Gao, Ling, Roberts, L Jackson, Chen, Yan, Morrow, Jason D The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4. Chem Res Toxicol, 15(9), 1114-8, 2002.
• Morrow, Jason D, Roberts, L Jackson The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Am J Respir Crit Care Med, 166(12 Pt 2), S25-30, 2002.
• Hou, X, Roberts, L J, Taber, D F, Morrow, J D, Kanai, K, Gobeil, F, Beauchamp, M H, Bernier, S G, Lepage, G, Varma, D R, Chemtob, S 2,3-Dinor-5,6-dihydro-15-F(2t)-isoprostane: a bioactive prostanoid metabolite. Am J Physiol Regul Integr Comp Physiol, 281(2), R391-400, 2001.
• Hou X, Roberts LJ, II, Morrow JD, Taber DF, Kanai K, Gobeil F, Varma DR, and Chemtob S "2,3-Dinor-5,6-dihydro-15-F2t-isoprostane is a bioactive isoprostane metabolite." Am. J. Physiol. Regulatory Comp. Physiol. , 281R391-R400, 2001.
• Dworski, R, Roberts, L J, Murray, J J, Morrow, J D, Hartert, T V, Sheller, J R Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin Exp Allergy, 31(3), 387-90, 2001.
• Dworski, R, Murray, JJ, Roberts, LJ, II, Oates, JA, Morrow, JD, Hartert, T, and Sheller, JR "Assment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2 )." Clin. Exp. Allergy, 31387-390, 2001.
• Youssef J, Birnbaum L, Roberts, LJ, II, Swift LL, Morrow J, and Badr M "Brain oxidative stress, senescence and death. Isoprostanes and neuroprostanes: novel markers and new theories." Antioxidants and Free Radicals in Health and Disease. J Marway, A Kanthasamy, Eds., Prominent Press, Scotsdale, pp. 261-278, 2001.
• Reich EE, Markesbery WR, Roberts LJ, II, Swift LL, Morrow JD, and Montine, TJ "Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease." Am. J. Pathol., 158293-297, 2001.
• Reich, E E, Markesbery, W R, Roberts, L J, Swift, L L, Morrow, J D, Montine, T J Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Am J Pathol, 158(1), 293-7, 2001.
• Boutand O, Brame CJ, Chaurand, P, Scott JL, Rowlinson SE, Crews BC, Chuan J, Marnett LJ, Roberts LJ, II, and Oates, JA "Characterization of the adducts of prostaglandin H synthases that are derived from oxygenation of arachidonic acid." Biochemistry, 406948-6955, 2001.
• Boutaud, O, Brame, C J, Chaurand, P, Li, J, Rowlinson, S W, Crews, B C, Ji, C, Marnett, L J, Caprioli, R M, Roberts, L J, Oates, J A Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry, 40(23), 6948-55, 2001.
• Lahaie O, Hardy P, Hou X, Hassessian H, Asselin P, Lachapelle P, Almazan G, Varma DR, Roberts LJ, II, and Chemtob S "Cytotoxic effects of thromboxane on neurovascular endothelial cells: Possible role in ischemic neuropathies." J. Appl. Physiol, 902279-2288, 2001.
• Barany P, Stenvinkel P, Ottosson-Seeberger, Alvestrand A, Morrow JD, Roberts LJ, II, and Salahudeen A "Effect of 6-weeks of vitamin E administration on renal hemodynamic alterations following a single dose of Neoral in healthy volunteers." Nephrol. Dial. Transplant., 16580-584, 2001.
• Patel, M, Liang, L P, Roberts, L J Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures. J Neurochem, 79(5), 1065-9, 2001.
• Bernoud-Hubac N, Davies SS, Boutaud O, Montine TJ, and Roberts LJ, II "Formation of highly reactive -ketoaldehydes (neuroketals) as products of the neuroprostane pathway." J. Biol. Chem, 27630964-30970, 2001.
• Bernoud-Hubac, N, Davies, S S, Boutaud, O, Montine, T J, Roberts, L J Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway. J Biol Chem, 276(33), 30964-70, 2001.
• Marathe GK, Harrison KA, Roberts LJ, II, Morrow JD, Murphy RC, Tjoelker LW, Prescott SM, Zimmerman GA, and McIntyre TM "Identification of platelet activating factor as the inflammatory lipid mediator in CCL4-induced rat liver damage." J. Lip. Res., 42587-596, 2001.
• Marathe, G K, Harrison, K A, Roberts, L J, Morrow, J D, Murphy, R C, Tjoelker, L W, Prescott, S M, Zimmerman, G A, McIntyre, T M Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. J Lipid Res, 42(4), 587-96, 2001.
• Salahudeen, A K, Oliver, B, Bower, J D, Roberts, L J Increase in plasma esterified F2-isoprostanes following intravenous iron infusion in patients on hemodialysis. Kidney Int, 60(4), 1525-31, 2001.
• Reich EE, Montine KS, Gross M, Roberts LJ, II, Swift LL, Morrow JD, and Montine TJ "Interactions between apolipoprotein E gene and dietary -tocopherol influence cerebral oxidative damage in aged mice." J. Neuroscience, 2159993-5999, 2001.
• Reich, E E, Montine, K S, Gross, M D, Roberts, L J, Swift, L L, Morrow, J D, Montine, T J Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. J Neurosci, 21(16), 5993-9, 2001.
• Roberts, L J, Reckelhoff, J F Measurement of F(2)-isoprostanes unveils profound oxidative stress in aged rats. Biochem Biophys Res Commun, 287(1), 254-6, 2001.
• Roberts, L J, Finch, P M, Goucke, C R, Price, L M Outcome of intrathecal opioids in chronic non-cancer pain. Eur J Pain, 5(4), 353-61, 2001.
• Boutaud, O, Li, J, Chaurand, P, Brame, C J, Marnett, L J, Roberts, L J, Oates, J A Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv Exp Med Biol, 500133-7, 2001.
• Reich, E E, Markesbery, W R, Roberts, L J, Swift, L L, Morrow, J D, Montine, T J Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Adv Exp Med Biol, 500253-6, 2001.
• Roberts, L J, Goucke, C R Retro-orbital tumour--an uncommon cause of headache in pregnancy. Anaesth Intensive Care, 29(3), 276-80, 2001.
• Kaikkonen, J, Porkkala-Sarataho, E, Morrow, J D, Roberts, L J, Nyyssönen, K, Salonen, R, Tuomainen, T P, Ristonmaa, U, Poulsen, H E, Salonen, J T Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men. Free Radic Res, 35(6), 967-78, 2001.
• Roberts, L J, Foote, S J, Handman, E A new standard for the assessment of disease progression in murine cutaneous leishmaniasis. Parasite Immunol, 22(5), 231-7, 2000.
• Hou X, Gobeil F, Peri K, Speranza G., Marrache M, Lachapelle P, Roberts LJ, II, Varma DR, and Chemtob S "Differential induction of vasoconstriction and thromboxane formation in immature pig periventricular brain microvessels by 15-F2t-isoprostane (8-iso-prostaglandin F2 )." Stroke, 31516-525, 2000.
• Phipps, R P, Pollock, S J, Kaur, K, Kaufman, J, Borrello, M A, Graf, B A, Nazarenko, D, Roberts, L J, Morrow, J D, Palis, J, Ryan, D J, Bennett, J M Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells. Curr Top Microbiol Immunol, 252293-300, 2000.
• Reich EE, Zackert WE, Brame CJ, Chen Y, Roberts LJ, II, Hachey DL, Montine TJ, and Morrow JD "Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid." Biochemistry, 392376-2383, 2000.
• Reich, E E, Zackert, W E, Brame, C J, Chen, Y, Roberts, L J, Hachey, D L, Montine, T J, Morrow, J D Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. Biochemistry, 39(9), 2376-83, 2000.
• Finch, P M, Roberts, L J, Price, L, Hadlow, N C, Pullan, P T Hypogonadism in patients treated with intrathecal morphine. Clin J Pain, 16(3), 251-4, 2000.
• Roberts, L J, Neal, D J, Kivlahan, D R, Baer, J S, Marlatt, G A Individual drinking changes following a brief intervention among college students: clinical significance in an indicated preventive context. J Consult Clin Psychol, 68(3), 500-5, 2000.
• Roberts, L J, Morrow, J D Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med, 28(4), 505-13, 2000.
• Roberts, LJ, II, and Morrow JD "Measurement of F2-isoprostanes as an index of oxidative stress in vivo." Free Rad. Biol. Med, 28505-513, 2000.
• O'Byrne, S, Forte, P, Roberts, LJ, II, Morrow, JD, Johnston, A, Angaard. E, Leslie, D, and Benjamin, N "Nitric oxide synthesis and isoprostane production in subjects with Type-1 diabetes and normal urinary albumin excretion." Diabetes , 49857-862, 2000.
• O'Byrne, S, Forte, P, Roberts, L J, Morrow, J D, Johnston, A, AnggÃ¥rd, E, Leslie, R D, Benjamin, N Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion. Diabetes, 49(5), 857-62, 2000.
• Montine, T J, Shinobu, L, Montine, K S, Roberts, L J, Kowall, N W, Beal, M F, Morrow, J D No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls. Ann Neurol, 48(6), 950, 2000.
• Walsh SW, Vaughan JE, Wang Y, and Roberts LJ, II "Placental isoprostane is significantly increased in preeclampsia." FASEB J., 141289-1296, 2000.
• Walsh, S W, Vaughan, J E, Wang, Y, Roberts, L J Placental isoprostane is significantly increased in preeclampsia. FASEB J, 14(10), 1289-96, 2000.
• Graf, B A, Nazarenko, D A, Borrello, M A, Roberts, L J, Morrow, J D, Phipps, R P Proinflammatory signals upregulate COX-2 and increase PGE2 production in biphenotypic B/macrophage cells. Ann N Y Acad Sci, 905294-6, 2000.
• Roberts, L J, Handman, E, Foote, S J Science, medicine, and the future: Leishmaniasis. BMJ, 321(7264), 801-4, 2000.
• Reckelhoff JF, Zhang H, Srivastava K, Roberts LJ, II, Morrow JD, and Romero JC "Subpressor doses of angiotensin II increase F2-isoprostanes and peroxynitrite in rats." Hypertension, 35476-479, 2000.
• Reckelhoff, J F, Zhang, H, Srivastava, K, Roberts, L J, Morrow, J D, Romero, J C Subpressor doses of angiotensin II increase plasma F(2)-isoprostanes in rats. Hypertension, 35(1 Pt 2), 476-9, 2000.
• Dworski, R, Murray, J J, Roberts, L J, Oates, J A, Morrow, J D, Fisher, L, Sheller, J R Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med, 160(6), 1947-51, 1999.
• Dworski R, Murray JJ, Roberts, LJ, II, Oates, JA, Morrow, JD, Fisher, L., and Sheller, JR "Allergen-induced synthesis of F2-isoprostanes in atopic asthmatics: evidence for oxidative stress." Am. J. Resp. Crit. Care Med., 1601947-1951, 1999.
• Graf, B A, Nazarenko, D A, Borrello, M A, Roberts, L J, Morrow, J D, Palis, J, Phipps, R P Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. Eur J Immunol, 29(11), 3793-803, 1999.
• Montine, T J, Beal, M F, Robertson, D, Cudkowicz, M E, Biaggioni, I, O'Donnell, H, Zackert, W E, Roberts, L J, Morrow, J D Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease. Neurology, 52(5), 1104-5, 1999.
• Montine, TJ, Beal, MF, Roberts, D, Cudkowicz, ME, Brown, RH, O'Donnel, H, Zackert, WE, Roberts, LJ, II, and Morrow, JD "Cerebrospinal levels of F2-isoprostanes, specific markers of lipid peroxidation, are elevated in Huntington's disease patients." Neurology, 521104-1105, 1999.
• Boutand, O, Brame, CJ, Salomon, RG, Roberts, LJ, II, and Oates, JA "Characterization of lysyl adducts formed from prostaglandin H2 via the levuglandin pathway." Biochemistry, 389389-9386, 1999.
• Boutaud, O, Brame, C J, Salomon, R G, Roberts, L J, Oates, J A Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry, 38(29), 9389-96, 1999.
• Roberts, L J, Baldwin, T M, Speed, T P, Handman, E, Foote, S J Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur J Immunol, 29(9), 3047-50, 1999.
• Reckelhof JF, Henntington, BS, Kanjii V, Racusen LC, Schmidt SD, Yan J, Morrow JD, Roberts LJ II, and Salahudeen AK "Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats." Am. J. Hypertenison, 12492-498, 1999.
• Reckelhoff, J F, Hennington, B S, Kanji, V, Racusen, L C, Schmidt, A M, Yan, S D, Morrow, J, Roberts, L J, Salahudeen, A K Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats. Am J Hypertens, 12(5), 492-8, 1999.
• Salahudeen A, Nawaz M, Poovala V, Kanjii V, Wang C, Morrow JD, and Roberts LJ II "Cold induces time-dependent F2-isoprostane formation in renal tubular cells and rat kidneys stored in University of Wisconsin solution: Implications for immediate post-transplant renal vasoconstriction." Kidney Internat, 551759-1762, 1999.
• Van der Veen, R, and Roberts, LJ, II "Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids." J. Neuroimmunol, 951-7, 1999.
• van der Veen, R C, Roberts, L J Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids. J Neuroimmunol, 95(1-2), 1-7, 1999.
• Roberts, L J Delegation for the novice nurse. Fla Nurse, 47(3), 9, 1999.
• Valyi-Nagy, T, Sidell, K R, Marnett, L J, Roberts, L J, Dermody, T S, Morrow, J D, Montine, T J Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. J Neuropathol Exp Neurol, 58(12), 1269-75, 1999.
• Valyi-Nagy, T, Sidell, KR, Marnett, LJ, Roberts, LJ, II, Dermody, TS, Morrow, JD, and Montine, TJ "Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis." J. Neuropath. Exp. Neurol., 581269-1275, 1999.
• Montine, T J, Sidell, K R, Crews, B C, Markesbery, W R, Marnett, L J, Roberts, L J, Morrow, J D Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology, 53(7), 1495-8, 1999.
• Montine, TJ, Sidell, KR, Crews, BC, Zackert, WE, Markesbery, WR, Marnett, Roberts, LJ, II, and Morrow, JD "Elevated CSF prostaglandin E2 levels in patients with probable AD." Neurology, 531495-1498, 1999.
• Voutilainen S, Morrow, JD, Roberts, LJ, II, Alfthan, G, Alho, H, Nyyssonen, K, and Salonen, JT "Enhanced in vivo lipid peoxidation at elevated plasma homocysteine levels." Ateriosclerosis Thromb. Vasc. Biol., 191263-1266, 1999.
• Voutilainen, S, Morrow, J D, Roberts, L J, Alfthan, G, Alho, H, Nyyssönen, K, Salonen, J T Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Arterioscler Thromb Vasc Biol, 19(5), 1263-6, 1999.
• Chen Y, Zackert WE, Roberts LJ II, and Morrow JD "Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-IsoP (8-iso-prostaglandin A2." Vivo. Biochim. Biophys. Acta, 1436550-556, 1999.
• Chen, Y, Zackert, W E, Roberts, L J, Morrow, J D Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-isoprostane (8-iso-prostaglandin A2) in vivo. Biochim Biophys Acta, 1436(3), 550-6, 1999.
• Roberts, LJ, II, and Morrow, JD "Formation of novel isoprostane-like compounds by free radical catalyzed peroxidation of docosahexaenoic acid." Essential Fatty Acids and Eicosanoids. RA Riemersma, RA Armstrong, RW Kelly, R Wilson, eds., AOCS press, Champaign, Ill, pp. 197-199, 1999.
• Morrow, J D, Tapper, A R, Zackert, W E, Yang, J, Sanchez, S C, Montine, T J, Roberts, L J Formation of novel isoprostane-like compounds from docosahexaenoic acid. Adv Exp Med Biol, 469343-7, 1999.
• Chen, Y, Morrow, JD, and Roberts, LJ, II "Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway." J. Biol. Chem., 27410863-10868, 1999.
• Chen, Y, Morrow, J D, Roberts, L J Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem, 274(16), 10863-8, 1999.
• Roberts, L J, Brame, C J, Chen, Y, Morrow, J D, Salomon, R G Formation of reactive products of the isoprostane pathway: isolevuglandins and cyclopentenone isoprostanes. Adv Exp Med Biol, 469335-41, 1999.
• Roberts, L J, Salem, D, Rappaport, J, Toro, P A, Luke, D A, Seidman, E Giving and receiving help: interpersonal transactions in mutual-help meetings and psychosocial adjustment of members. Am J Community Psychol, 27(6), 841-68, 1999.
• Brame, C J, Salomon, R G, Morrow, J D, Roberts, L J Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts. J Biol Chem, 274(19), 13139-46, 1999.
• Montine, T J, Beal, M F, Cudkowicz, M E, O'Donnell, H, Margolin, R A, McFarland, L, Bachrach, A F, Zackert, W E, Roberts, L J, Morrow, J D Increased CSF F2-isoprostane concentration in probable AD. Neurology, 52(3), 562-5, 1999.
• Montine, TJ, Beal, MF, Cudkowicz, MD, O'Donnel, H, Margolin, RA, McFarland, L., Cachrach, AF, Zackert, WE, Roberts, LJ, II, and Morrow, JD "Increased CSF F2-isoprostane concentration in probable AD." Neurology, 52562-565, 1999.
• Montine, T J, Montine, K S, Olson, S J, Graham, D G, Roberts, L J, Morrow, J D, Linton, M F, Fazio, S, Swift, L L Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Exp Neurol, 158(1), 234-41, 1999.
• Montine, TJ, Montine, KS, Olson, SJ, Graham, DG, Roberts, LJ, II, Morrow, JD, Swift, LL, Linton, M, and Fazio, S "Increased cerebral cortical products of lipid peroxidation (Neuroprostanes) and abnormal phospholipids in aged homozygous ApoE deficient C57BL/Cj mice." Exp. Neurol., 158234-241, 1999.
• Morrow, J D, Oates, J A, Roberts, L J, Zackert, W E, Mitchell, T A, Lazarus, G, Guzzo, C Increased formation of thromboxane in vivo in humans with mastocytosis. J Invest Dermatol, 113(1), 93-7, 1999.
• Holt, S, Reeder, B, Wilson, M, Harvey, S, Morrow, JD, Roberts, LJ, II, and Moore, K "Increased lipid peroxidation in patients with rhabdomyolysis." Lancet, 3531241, 1999.
• Holt, S, Reeder, B, Wilson, M, Harvey, S, Morrow, J D, Roberts, L J, Moore, K Increased lipid peroxidation in patients with rhabdomyolysis. Lancet, 353(9160), 1241, 1999.
• Roberts, LJ, II, and Morrow, JD "Isoprostanes as markers of lipid peroxidation in atherosclerosis." Molecular Biology of Inflammation. CN Serhan, PA Ward, eds., Humana Press, pp 141-163, 1999.
• Barlow, C, Dennery, P A, Shigenaga, M K, Smith, M A, Morrow, J D, Roberts, L J, Wynshaw-Boris, A, Levine, R L Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. Proc Natl Acad Sci U S A, 96(17), 9915-9, 1999.
• Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Roberts LJ, II, Wynshaw-Boris A, and Levine RL "Loss of the ataxia-telangiectasia gene products causes oxidative damage in target organs." Proc. Natl. Acad. Sci. USA, 969915-9919, 1999.
• Morrow, J D, Roberts, L J Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol, 3003-12, 1999.
• Jacobson, NS, Roberts, LJ, Berns, SB, McGlinchey, JB Methods for defining and determining the clinical significance of treatment effects: description, application, and alternatives. J Consult Clin Psychol, 67(3), 300-7, 1999.
• Choong, K Y, Roberts, L J Molluscum contagiosum, swimming and bathing: a clinical analysis. Australas J Dermatol, 40(2), 89-92, 1999.
• Roberts, LJ, II, Salomon, RG, Morrow, JD, and Brame, CJ "New developments in the isoprostane pathway: Identification of novel highly reactive -ketoaldehydes (isolevuglandins) and characterization of their protein adducts." FASEB J, 131157-1168, 1999.
• Roberts, L J, Salomon, R G, Morrow, J D, Brame, C J New developments in the isoprostane pathway: identification of novel highly reactive gamma-ketoaldehydes (isolevuglandins) and characterization of their protein adducts. FASEB J, 13(10), 1157-68, 1999.
• Roberts, L J, Brame, C J, Chen, Y, Morrow, J D Novel eicosanoids. Isoprostanes and related compounds. Methods Mol Biol, 120257-85, 1999.
• Roberts, LJ, II, Brame, CJ, Chen, Y, and Morrow, JD "Novel eicosanoids: Isoprostanes and related compounds." Methods in Molecular Biology, vol. 120, (E. A. Lianos, ed) Humana Press, Totowa, NJ, 257-285, 1999.
• Mills, J L, DerSimonian, R, Raymond, E, Morrow, J D, Roberts, L J, Clemens, J D, Hauth, J C, Catalano, P, Sibai, B, Curet, L B, Levine, R J Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. JAMA, 282(4), 356-62, 1999.
• Salomon, R G, Sha, W, Brame, C, Kaur, K, Subbanagounder, G, O'Neil, J, Hoff, H F, Roberts, L J Protein adducts of iso[4]levuglandin E2, a product of the isoprostane pathway, in oxidized low density lipoprotein. J Biol Chem, 274(29), 20271-80, 1999.
• Salomon, RG, Sha W, Brame, C, Kaur, K, Subbanagounder, G, O'Neil, J, Hoff, HF, and Roberts, LJ, II "Protein adducts of isolevuglandin E2 in oxidized low density lipoprotein." J. Biol. Chem., 27420271-20280, 1999.
• Morrow, J D, Zackert, W E, Yang, J P, Kurhts, E H, Callewaert, D, Dworski, R, Kanai, K, Taber, D, Moore, K, Oates, J A, Roberts, L J Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal Biochem, 269(2), 326-31, 1999.
• Morrow JD, Zackert WE, Yang JP, Kurhts EH, Callewaert D, Kanai, K, Taber DF, Moore, KP, Oates JA, and Roberts LJ II "Quantification of the major urinary metabolite of the isoprostane 15-F2t-isoprostane (8-iso-PGF2 ) by stable isotope dilution mass spectrometric assay." Anal. Biochem., 269326-331, 1999.
• Morrow, JD, Chen, Y, Brame, CJ, Yang, J, Sanchez, SC, Xu, J, Zackert, WE, and Roberts, LJ, II "The isoprostanes: Unique prostaglandin-like products of free radical-catalyzed lipid peroxidation." Drug Metab. Rev., 31117-139, 1999.
• Liu, T, Stern, A, Roberts, L J, Morrow, J D The isoprostanes: novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid. J Biomed Sci, 6(4), 226-35, 1999.
• Liu T, Stern A, Roberts LJ, II, and Morrow JD "The isoprostanes: novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid." J. Biomed. Sci, 6226-235, 1999.
• Morrow, J D, Chen, Y, Brame, C J, Yang, J, Sanchez, S C, Xu, J, Zackert, W E, Awad, J A, Roberts, L J The isoprostanes: unique prostaglandin-like products of free-radical-initiated lipid peroxidation. Drug Metab Rev, 31(1), 117-39, 1999.
• Montine TJ, Markesbery WR, Zackert W, Sanchez SC, Roberts LJ, II, and Morrow JD "The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APE Genotype in Alzheimer's disease patients." Am. J. Pathol., 155863-868, 1999.
• Montine, T J, Markesbery, W R, Zackert, W, Sanchez, S C, Roberts, L J, Morrow, J D The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients. Am J Pathol, 155(3), 863-8, 1999.
• Moore, K, and Roberts, LJ, II "Measurement of lipid peroxidation." Free Rad. Res., 28659-671, 1998.
• Moore K, Patel, R, Darley-Usmar, V, Holt, S, Zackert WE, Clozel, M, Anand, R, Wilson, M, Harvey, S, Morrow, JD, and Roberts, LJ, II "A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure." J. Biol. Chem., 27331731-31737, 1998.
• Moore, K P, Holt, S G, Patel, R P, Svistunenko, D A, Zackert, W, Goodier, D, Reeder, B J, Clozel, M, Anand, R, Cooper, C E, Morrow, J D, Wilson, M T, Darley-Usmar, V, Roberts, L J A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J Biol Chem, 273(48), 31731-7, 1998.
• Lahaie, I, Hardy, P, Hou, X, Hassessian, H, Asselin, P, Lachapelle, P, Almazan, G, Varma, DR, Morrow, J.D, Roberts, LJ, II, and Chemtob, S "A novel mechanism for the vasoconstrictor action of 8-iso-prostaglandin F2 on retinal blood vessels. Am. J. Physiol.274 (Regulatory Integrative Comp." Physiol, 4(3), R1406-R1416, 1998.
• Lahaie, I, Hardy, P, Hou, X, Hasséssian, H, Asselin, P, Lachapelle, P, Almazan, G, Varma, D R, Morrow, J D, Roberts, L J, Chemtob, S A novel mechanism for vasoconstrictor action of 8-isoprostaglandin F2 alpha on retinal vessels. Am J Physiol, 274(5 Pt 2), R1406-16, 1998.
• Montine, T J, Markesbery, W R, Morrow, J D, Roberts, L J Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Ann Neurol, 44(3), 410-3, 1998.
• Montine, TJ, Markesbery, WR, Morrow, JD, and Roberts, LJ, II "Cerebrospinal fluid F2-isoprostane levels are increased in patients with Alzheimer's disease." Annals Neurol, 44410-413, 1998.
• Salahudeen, A, Wilson, P, Pande, R, Poovala, V, Kanji, V, Ansari, N, Morrow, JD, and Roberts, LJ, II "Cisplatin induces N-acetyl cysteine suppressible F2-isoprostane production and injury in renal tubular epithelial cells." J. Am. Soc. Nephrol., 91448-1455, 1998.
• Morrow, J D, Roberts, L J, Daniel, V C, Awad, J A, Mirochnitchenko, O, Swift, L L, Burk, R F Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. Arch Biochem Biophys, 353(1), 160-71, 1998.
• Morrow, JD, Roberts, LJ, II, Daniel, VC, Mirotchnechenko, O, Swift, L., and Burk, RF "Comparison of the formation of D2/E2-Isoprostanes to F2-isoprostanes in vitro and in vivo: Effect of oxygen tension and glutathione." Arch. Biochem. Biophys, 353160-171, 1998.
• Kadiiska, MB, Morrow, JD, Awad, JA, Roberts, LJ, II, and Mason, RP "Enhanced formation of free radicals and F2-isoprostanes in vivo by acute Cr (VI) poisoning." Chem. Res. Toxicol., 111516-1520, 1998.
• Morrow, J D, Scruggs, J, Chen, Y, Zackert, W E, Roberts, L J Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo. J Lipid Res, 39(8), 1589-93, 1998.
• Morrow, JD, Scruggs, J, Chen, Y, Zackert, WE, and Roberts, LJ, II "Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-isoprostaglandin E2) is formed in vivo." J.Lip.Res, 391589-1593, 1998.
• Salahudeen, AK, Reckelhoff, JF, Morrow, JD, and Roberts, LJ, II "F2- isoprostanes and the kidney." Drug News & Perspectives, 11287-290, 1998.
• Salahudeen, AK, Reckelhoff, JF, Morrow, JD, Roberts, LJ F2-isoprostanes and the kidney. Drug News Perspect, 11(5), 287-90, 1998.
• Roberts, LJ, II, Montine, TJ, Markesbery, WR, Tapper, AR, Hardy P, Chemtob, C, Dettbarn, WD, and Morrow, JD. "Formation of isoprostane- like compounds (Neuroprostanes) in vivo from docosahexaenoic acid." J. Biol. Chem., 27313605-13612, 1998.
• Roberts, L J, Montine, T J, Markesbery, W R, Tapper, A R, Hardy, P, Chemtob, S, Dettbarn, W D, Morrow, J D Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem, 273(22), 13605-12, 1998.
• Kadiiska, M B, Morrow, J D, Awad, J A, Roberts, L J, Mason, R P Identification of free radical formation and F2-isoprostanes in vivo by acute Cr(VI) poisoning. Chem Res Toxicol, 11(12), 1516-20, 1998.
• Bolton, P G, Mira, M, Roberts, L J, Usher, H E Is health care card status related to consultation time?. Med J Aust, 168(10), 527-8, 1998.
• Morrow, JD, and Roberts, LJ, II "Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress." Methods Enzymol., 3003-12, 1998.
• Moore, K, Roberts, L J Measurement of lipid peroxidation. Free Radic Res, 28(6), 659-71, 1998.
• Shaner, A, Roberts, L J, Eckman, T A, Racenstein, J M, Tucker, D E, Tsuang, J W, Mintz, J Sources of diagnostic uncertainty for chronically psychotic cocaine abusers. Psychiatr Serv, 49(5), 684-90, 1998.
• Barrett, R S, Neal, R J, Roberts, L J The dynamic loading response of surfaces encountered in beach running. J Sci Med Sport, 1(1), 1-11, 1998.
• Leonard, K E, Roberts, L J The effects of alcohol on the marital interactions of aggressive and nonaggressive husbands and their wives. J Abnorm Psychol, 107(4), 602-15, 1998.
• Morrow, JD, Chen, Y, Zackert, WE, and Roberts, LJ, II "The isoprostanes: recent advances." Biological Oxidants and Antioxidants: Molecular Mechanisms and Health Effects. L. Packer, ed., AOCS, pp.72-78, 1998.
• Reckelhoff, J F, Kanji, V, Racusen, L C, Schmidt, A M, Yan, S D, Marrow, J, Roberts, L J, Salahudeen, A K Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. Am J Physiol, 274(3 Pt 2), R767-74, 1998.
• Kanji, V, Racusen L, Schmidt, AM, Yan, SD, Morrow, JD, Roberts, LJ, II, and Salahudeen, AK "Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys." Am. J. Physiol., 274R767-774, 1998.
• Taber, DF, Morrow, JD, and Roberts, LJ, II "A nomenclature system for the isoprostanes." Prostaglandins, 5363-67, 1997.
• Taber, D F, Morrow, J D, Roberts, L J A nomenclature system for the isoprostanes. Prostaglandins, 53(2), 63-7, 1997.
• Berger, TM, Polidori, MC, Dabbagh, A, Evans, PJ, Halliwell, B, Morrow, JD, and Roberts, LJ, II, Avery, ME, and Frei, B "Antioxidant activity of vitamin C in iron-overloaded human plasma." J. Biol. Chem, 2515656-15660, 1997.
• Berger, T M, Polidori, M C, Dabbagh, A, Evans, P J, Halliwell, B, Morrow, J D, Roberts, L J, Frei, B Antioxidant activity of vitamin C in iron-overloaded human plasma. J Biol Chem, 272(25), 15656-60, 1997.
• DuBois, R, Tsujii, M, Morrow, J, Awad, J, Roberts, L, Bishop, P Eicosanoid production and growth regulation in rat intestinal epithelial cells. Adv Exp Med Biol, 400A487-93, 1997.
• Soliman, M S, Cunningham, M L, Morrow, J D, Roberts, L J, Badr, M Z Evidence against peroxisome proliferation-induced hepatic oxidative damage. Biochem Pharmacol, 53(9), 1369-74, 1997.
• Soliman MS, Cunningham ML, Morrow JD, Roberts LJ, II, and Badr MZ "Evidence against peroxisome proliferation-induced hepatic oxidative damage." Biochem. Pharmacol, 531369-1374, 1997.
• Garabedian, E M, Roberts, L J, McNevin, M S, Gordon, J I Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem, 272(38), 23729-40, 1997.
• Roberts, LJ, II, and Morrow, JD "Generation and actions of isoprostanes." Biochim. Biophys. Acta., 1345 121-135, 1997.
• Waugh RJ, Morrow, JD, Roberts, LJ, II, and Murphy RC "Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat." Free Rad. Biol. Med, 23943-954, 1997.
• Waugh, R J, Morrow, J D, Roberts, L J, Murphy, R C Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. Free Radic Biol Med, 23(6), 943-54, 1997.
• Smith, C J, Morrow, J D, Roberts, L J, Marnett, L J Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA. Adv Exp Med Biol, 400A99-106, 1997.
• Shaner, A, Roberts, L J, Eckman, T A, Tucker, D E, Tsuang, J W, Wilkins, J N, Mintz, J Monetary reinforcement of abstinence from cocaine among mentally ill patients with cocaine dependence. Psychiatr Serv, 48(6), 807-10, 1997.
• Melanson, M, Nalbantoglu, J, Berkovic, S, Melmed, C, Andermann, E, Roberts, L J, Carpenter, S, Snipes, G J, Andermann, F Progressive myoclonus epilepsy in young adults with neuropathologic features of Alzheimer's disease. Neurology, 49(6), 1732-3, 1997.
• Gniwotta, C, Morrow, J D, Roberts, L J, Kühn, H Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol, 17(11), 3236-41, 1997.
• Gniwotta, C, Morrow, JD, Roberts, LJ, II, and Kuhn, H "Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions." J. Arteriosclerosis Thromb. Vasc. Biol., 17236-3241, 1997.
• Roberts, L J, Baldwin, T M, Curtis, J M, Handman, E, Foote, S J Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med, 185(9), 1705-10, 1997.
• Roberts, L J, Morrow, J D The generation and actions of isoprostanes. Biochim Biophys Acta, 1345(2), 121-35, 1997.
• Morrow, JD, and Roberts, LJ, II "The isoprostanes: unique bioactive products of lipid peroxidation." Prog. Lipid Res., 361-21, 1997.
• Morrow, J D, Roberts, L J The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res, 36(1), 1-21, 1997.
• Lynch, SM, Frei, B, Morrow, JD, Roberts, LJ, II, Xu, A, Jackson, T, Reyna, R, Klevay, LM, Vita, JA, and Keaney, JF, Jr "Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation." Arteriosclerosis Thrombosis, Vasc. Biol., 172975-2981, 1997.
• Lynch, S M, Frei, B, Morrow, J D, Roberts, L J, Xu, A, Jackson, T, Reyna, R, Klevay, L M, Vita, J A, Keaney, J F Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. Arterioscler Thromb Vasc Biol, 17(11), 2975-81, 1997.
• Awad, J A, Horn, J L, Roberts, L J, Franks, J J Demonstration of halothane-induced hepatic lipid peroxidation in rats by quantification of F2-isoprostanes. Anesthesiology, 84(4), 910-6, 1996.
• Awad, JA, Horn, J-L, Roberts, LJ, II, and Franks, JJ "Demonstration of halothane-induced hepatic lipid peroxidation in rats using F2-isoprostanes." Anesthesiology, 84910-916, 1996.
• Yang, Z P, Morrow, J, Wu, A, Roberts, L J, Dettbarn, W D Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochem Pharmacol, 52(2), 357-61, 1996.
• Bartsch, P, Vock, P, Roberts, LJ, II, and Ballmer, PE "Evidence against a dominant role for increased capillary permeability in the development of acute mountain sickness and high altitude pulmonary edema." J. Appl. Physiol, 811917-1923, 1996.
• Kleger, G R, Bärtsch, P, Vock, P, Heilig, B, Roberts, L J, Ballmer, P E Evidence against an increase in capillary permeability in subjects exposed to high altitude. J Appl Physiol, 81(5), 1917-23, 1996.
• Stein, CM, Awad, JA, Tanner, SB, Roberts, LJ, II, and Morrow, JD "Evidence for free radical mediated injury (isoprostane overproduction) in scleroderma." Arthtitis and Rheumatism, 391146-1150, 1996.
• Stein, C M, Tanner, S B, Awad, J A, Roberts, L J, Morrow, J D Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma. Arthritis Rheum, 39(7), 1146-50, 1996.
• Morrow, JD, Awad, JA, Wu, A., Zackert, WE, Daniel, VC, and Roberts, LJ, II "Free radical-induced generation of thromboxane-like compounds (isothromboxanes) in vivo." J. Biol. Chem, 27123185-23190, 1996.
• Roberts, L J, Moore, K P, Zackert, W E, Oates, J A, Morrow, J D Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2alpha in humans. J Biol Chem, 271(34), 20617-20, 1996.
• Roberts, L J, II, Moore, KP, Zackert, WE, Oates, JA, and Morrow, JD "Identification of the major urinary metabolite of the F2-isoprostane, 8-iso-prostaglandin F2 , in humans." J. Biol. Chem., 27120617-20620, 1996.
• Yang, ZP, Wu, A, Morrow, JD, Roberts, LJ, II, and Dettbarn, W-D "Increases in malondialdehyde-thiobarbituric acid complex (MDA-TBA) and F2-isoprostanes in diisopropyl fluorophosphate induced muscle hyperactivity." Biochem. Pharmacol., 52357-361, 1996.
• Awad, JA, Roberts, LJ, II, Burk, RA, Morrow, JD "Isoprostanes, prostaglandin-like compounds formed in vivo independently of the cyclooxygenase: Use as clinical indicator of oxidant damage." Gastroenterology Clinics N. Am., 25409-427, 1996.
• Awad, J A, Roberts, L J, Burk, R F, Morrow, J D Isoprostanes--prostaglandin-like compounds formed in vivo independently of cyclooxygenase: use as clinical indicators of oxidant damage. Gastroenterol Clin North Am, 25(2), 409-27, 1996.
• Roberts, L J Knowledge and use of periconceptual folic acid supplements by British Forces Germany personnel and dependents. J R Army Med Corps, 142(3), 116-9, 1996.
• Morrow, JD, and Roberts, LJ, II "Measurement of F2-isoprostanes: prostaglandin-like products of lipid peroxidation." Free Radicals: A Practical Approach. NA Punchard and FJ Kelly, Eds., Oxford University Press, New York, pp. 147-157, 1996.
• Morrow, J D, Awad, J A, Wu, A, Zackert, W E, Daniel, V C, Roberts, L J Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. J Biol Chem, 271(38), 23185-90, 1996.
• Awas, J A, Soteriou, M C, Drougas, J G, Stokes, K A, Roberts, L J, Pinson, C W Plasma prostaglandin E1 concentrations and hemodynamics during intravenous infusions of prostaglandin E1 in humans and swine. Transplantation, 61(11), 1624-9, 1996.
• Choong, K Y, Roberts, L J Ritual Samoan body tattooing and associated sporotrichosis. Australas J Dermatol, 37(1), 50-3, 1996.
• Itoh, S, Morrow, JD, Roberts, LJ, II, and Schuster, VL "Structural determinants of substrates for the prostaglandin transporter "PGT." Mol. Pharmacol., 50736-742, 1996.
• Itoh, S, Lu, R, Bao, Y, Morrow, J D, Roberts, L J, Schuster, V L Structural determinants of substrates for the prostaglandin transporter PGT. Mol Pharmacol, 50(4), 738-42, 1996.
• Morrow, J D, Roberts, L J The isoprostanes. Current knowledge and directions for future research. Biochem Pharmacol, 51(1), 1-9, 1996.
• Morrow, JD, and Roberts, LJ, II "The isoprostanes: current knowledge and directions for future research." Biochem. Pharmacol, 511-9,, 1996.
• Moore, KP, Darley-Usmar, V, Morrow JD, and Roberts, LJ, II "Formation of F2-isoprostanes during the oxidation of human low density lipoprotein and plasma by peroxynitrite." Circ. Res, 77335-341, 1995.
• Simon, TC, Roberts, LJ, Gordon, JI A 20-nucleotide element in the intestinal fatty acid binding protein gene modulates its cell lineage-specific, differentiation-dependent, and cephalocaudal patterns of expression in transgenic mice. Proc Natl Acad Sci U S A, 92(19), 8685-9, 1995.
• Awad, J, Morrow, J, Roberts, L J Comments on prostaglandin F2 alpha rises in response to hydroxyl radical generated in vivo. Free Radic Biol Med, 19(6), 944-6, 1995.
• Shaner, A, Eckman, TA, Roberts, LJ, Wilkins, JN, Tucker, DE, Tsuang, JW, Mintz, J Disability income, cocaine use, and repeated hospitalization among schizophrenic cocaine abusers--a government-sponsored revolving door. N Engl J Med, 333(12), 777-83, 1995.
• Rangachari, P K, Betti, P A, Prior, E T, Roberts, L J Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor?. J Pharmacol Exp Ther, 275(2), 611-7, 1995.
• Roberts, L J, Bewley, S, Mackinson, A M, Rodeck, C H First trimester fetal nuchal translucency: problems with screening the general population. 1. Br J Obstet Gynaecol, 102(5), 381-5, 1995.
• Bewley, S, Roberts, L J, Mackinson, A M, Rodeck, C H First trimester fetal nuchal translucency: problems with screening the general population. 2. Br J Obstet Gynaecol, 102(5), 386-8, 1995.
• Moore, K P, Darley-Usmar, V, Morrow, J, Roberts, L J Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite. Circ Res, 77(2), 335-41, 1995.
• Moore, K P, Darley-Usmar, V, Morrow, J, Roberts, L J Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite. Adv Prostaglandin Thromboxane Leukot Res, 23225-7, 1995.
• Salahucleen, A, Bach, K, Morrow, JD, and Roberts, LJ, II "Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells." J. Am. Soc. Nephrol., 61300-1303, 1995.
• Morrow, J D, Guzzo, C, Lazarus, G, Oates, J A, Roberts, L J Improved diagnosis of mastocytosis by measurement of the major urinary metabolite of prostaglandin D2. J Invest Dermatol, 104(6), 937-40, 1995.
• Morrow, J D, Frei, B, Longmire, A W, Gaziano, J M, Lynch, S M, Shyr, Y, Strauss, W E, Oates, J A, Roberts, L J Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med, 332(18), 1198-203, 1995.
• Morrow, JD, Frei, B, Longmire, AW, Gaziano, JM, Lynch, SM, Strauss, WE, Oates, JA, Roberts, LJ, II "Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers: Smoking as a cause of oxidative damage." N. Eng. J. Med., 3321198-1203, 1995.
• Murray, J., Mullins, M., Knapp, H., Keller, S., Serafin, W., Roberts, L., Struthers, B., Oates, J Regulation of the Immune Response by Eicosanoids: Pharmacology and Clinical Effects of Prostaglandin E in Aspirin-Sensitive Syndromes. Am J Ther, 2(10), 739-748, 1995.
• Roberts, L J, Morrow, J D The isoprostanes: novel markers of lipid peroxidation and potential mediators of oxidant injury. Adv Prostaglandin Thromboxane Leukot Res, 23219-24, 1995.
• Downard, C D, Roberts, L J, Morrow, J D Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. Clin Pharmacol Ther, 57(4), 441-5, 1995.
• Longmire, A W, Roberts, L J, Morrow, J D Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. Prostaglandins, 48(4), 247-56, 1994.
• Longmire, AW, Roberts, LJ, II, and Morrow, J.D "Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor." Prostaglandins, 48247-256, 1994.
• Stein, DM, Longmire, AW, Minton, TA, Roberts, LJ, II, Pincus, MD, and Morrow, JD "Cyclosporine-induced alterations in renal function are not associated with lipid peroxidation." Transplantation, 58386-388, 1994.
• Stein, C M, Longmire, A W, Minton, T A, Roberts, L J, Pincus, T, Morrow, J D Cyclosporine-induced alterations in renal function are not associated with lipid peroxidation. Transplantation, 58(3), 386-8, 1994.
• Awad, J A, Morrow, J D, Hill, K E, Roberts, L J, Burk, R F Detection and localization of lipid peroxidation in selenium- and vitamin E-deficient rats using F2-isoprostanes. J Nutr, 124(6), 810-6, 1994.
• Awad, JA, Morrow, JD, Hill, KE, Roberts, LJ, II, and Burk, RF "Detection and localization of lipid peroxidation in vitamin E and selenium deficient rats using F2-isoprostanes." J. Nutr., 124810-816, 1994.
• Awad, J A, Morrow, J D, Roberts, L J Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. J Allergy Clin Immunol, 93(5), 817-24, 1994.
• Longmire, AW, Swift, LL, Roberts, LJ, II, Awad, JA, Burk, RF, and Morrow, J.D "Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes." Biochem. Pharmacol., 471173-1177, 1994.
• Longmire, A W, Swift, L L, Roberts, L J, Awad, J A, Burk, R F, Morrow, J D Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol, 47(7), 1173-7, 1994.
• Awad, JA, Burk, RF, and Roberts, LJ, II "Effect of selenium deficiency and glutathione modulating agents on diquat toxicity and lipid peroxidation." J. Pharmac. Exp. Therap., 270858-864, 1994.
• Awad, J A, Burk, R F, Roberts, L J Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats. J Pharmacol Exp Ther, 270(3), 858-64, 1994.
• Morrow, JD, Badr, KF, and Roberts, LJ, II "Evidence that the F2-isoprostane, 8-epi-PGF2 , is formed in vivo." Biochim. Biophys. Acta., 1210244-248, 1994.
• Morrow, J D, Minton, T A, Badr, K F, Roberts, L J Evidence that the F2-isoprostane, 8-epi-prostaglandin F2 alpha, is formed in vivo. Biochim Biophys Acta, 1210(2), 244-8, 1994.
• Lynch, SM, Morrow, JD, Roberts, LJ, II, and Frei, B "Formation of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in human plasma and isolated low density lipoproteins exposed to metal ion-dependent and -independent oxidative stress." J. Clin. Invest., 93998-1004, 1994.
• Lynch, S M, Morrow, J D, Roberts, L J, Frei, B Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Invest, 93(3), 998-1004, 1994.
• Morrow, JD, Minton, TA, Mukundan, CR, Campbell, MD, Zackert, WE, Daniel, VC. Badr, KF, Blair, IA, and Roberts, LJ, II "Free radical induced generation of isoprostanes in vivo: Evidence for the formation of D-ring and E-ring isoprostanes." J. Biol. Chem., 2694317-4326, 1994.
• Morrow, J D, Minton, T A, Mukundan, C R, Campbell, M D, Zackert, W E, Daniel, V C, Badr, K F, Blair, I A, Roberts, L J Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem, 269(6), 4317-26, 1994.
• Nassar, G M, Morrow, J D, Roberts, L J, Lakkis, F G, Badr, K F Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J Biol Chem, 269(44), 27631-4, 1994.
• Roberts, L J, Morrow, J D Isoprostanes. Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury. Ann N Y Acad Sci, 744237-42, 1994.
• Roberts, LJ, II, and Morrow, JD "Isoprostanes: Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury." Annals N.Y. Acad. Sci, 744237-242, 1994.
• Roberts, L J, Beardsworth, S A, Trew, G Labour following caesarean section: current practice in the United Kingdom. Br J Obstet Gynaecol, 101(2), 153-5, 1994.
• Morrow, JD, and Roberts, LJ, II "Mass spectrometric method for quantification of prostanoids (F2-isoprostanes) produced by a non-cyclooxygenase free radical catalyzed mechanism." Methods Enzymol., 233163-174, 1994.
• Morrow, J D, Roberts, L J Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism. Methods Enzymol, 233163-74, 1994.
• Crosland, J G, Roberts, L J Pulsed dye laser therapy for port-wine stains in children. J Pediatr, 124(1), 161-2, 1994.
• DuBois, R N, Awad, J, Morrow, J, Roberts, L J, Bishop, P R Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest, 93(2), 493-8, 1994.
• Morrow, J D, Minton, T A, Awad, J A, Roberts, L J Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. Arch Dermatol, 130(11), 1408-12, 1994.
• Rodeck, C H, Roberts, L J Successful treatment of fetal cardiac arrest by left ventricular exchange transfusion. Fetal Diagn Ther, 9(4), 213-7, 1994.
• Kang, K H, Morrow, J D, Roberts, L J, Newman, J H, Banerjee, M Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung. J Appl Physiol, 74(1), 460-5, 1993.
• Kang, HK, Morrow, JD, Roberts, LJ, II, Newman, JH, and Banerjee, M "Airway and vascular effects of 8-epi-prostaglandin F2 in isolated perfused rat lung." J. Appl. Physiol., 74460-465, 1993.
• Kayganich, KA, Rose, DM, Murphy, RC, Morrow, JD, and Roberts, LJ, II "Collision induced dissociation of isoprostane-containing phospholipids." J. Lipid Res., 341229-1235, 1993.
• Kayganich-Harrison, K A, Rose, D M, Murphy, R C, Morrow, J D, Roberts, L J Collision-induced dissociation of F2-isoprostane-containing phospholipids. J Lipid Res, 34(7), 1229-35, 1993.
• Smith, C J, Morrow, J D, Roberts, L J, Marnett, L J Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1). Biochem Biophys Res Commun, 192(2), 787-93, 1993.
• Fukunaga, M, Makita, N, Roberts, L J, Morrow, J D, Takahashi, K, Badr, K F Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol, 264(6 Pt 1), C1619-24, 1993.
• Fukunaga, M, Makita, N, Roberts, LJ, II, Morrow, JD, Takahashi, K, and Badr, KF "Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells." Am. J. Physiol., 263(Cell Physiol.33)C1619-C1624, 1993.
• Awad, JA, Morrow, JD, and Roberts, LJ, II "Identification of metabolites of noncyclooxygenase derived prostaglandin F2-like compounds (F2-isoprostanes) in human urine and plasma." J. Biol. Chem., 2684161-4169, 1993.
• Awad, J A, Morrow, J D, Takahashi, K, Roberts, L J Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma. J Biol Chem, 268(6), 4161-9, 1993.
• Roberts, L J Induction of labour. BMJ, 307(6895), 66-7, 1993.
• Morrow, J D, Moore, K P, Awad, J A, Ravenscraft, M D, Marini, G, Badr, K F, Williams, R, Roberts, L J Marked overproduction of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome. J Lipid Mediat, 6(1-3), 417-20, 1993.
• Morrow, JD, Moore, KP, Awad, JA, Ravenscraft, MD, Marini, G, Badr, KF, Williams, R, and Roberts, LJ, II "Marked overproduction of non-cycloxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome." J. Lip. Mediators, 6417-420, 1993.
• Cox, S E, Roberts, L J, Bergstresser, P R Prevention of skin cancer in xeroderma pigmentosum: the physician as advocate. J Am Acad Dermatol, 29(6), 1045-6, 1993.
• Spatz, M, Stanimirovic, D, Uematsu, S, Roberts, L J, Bembry, J, McCarron, R M Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain. Prostaglandins Leukot Essent Fatty Acids, 49(4), 789-93, 1993.
• Awad, J A, Morrow, J D, Roberts, L J Simplification of the mass spectrometric assay for the major urinary metabolite of prostaglandin D2. J Chromatogr, 617(1), 124-8, 1993.
• Roberts, L J, Knight, V A A physiologic concept of exercise-induced pulmonary hemorrhage in horses. J Am Vet Med Assoc, 201(5), 666-7, 1992.
• Roberts, L J, Shaner, A, Eckman, T A, Tucker, D E, Vaccaro, J V Effectively treating stimulant-abusing schizophrenics: mission impossible?. New Dir Ment Health Serv, (53), 55-65, 1992.
• Banerjee, M, Kang, KH, Morrow, JD, Roberts, LJ, II, and Newman, JH "Effects of a novel non-cyclooxygenase derived prostaglandin, 8-epi-PGF2 , in rabbit lung in situ." Am. J. Physiol. 263, (Heart Circ. Physiol 32)H660-H663, 1992.
• Banerjee, M, Kang, K H, Morrow, J D, Roberts, L J, Newman, J H Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ. Am J Physiol, 263(3 Pt 2), H660-3, 1992.
• Morrow, JD, Awad, JA, Kato, T, Takahashi, K, Badr, KF, Roberts, LJ, II, and Burk, R.F "Formation of novel non-cyclooxygenase derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity, an animal model of lipid peroxidation." J. Clin. Invest., 902502-2507, 1992.
• Morrow, J D, Awad, J A, Kato, T, Takahashi, K, Badr, K F, Roberts, L J, Burk, R F Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J Clin Invest, 90(6), 2502-7, 1992.
• Takahashi, K, Nammour, TM, Ebert, J, Morrow, JD, Roberts, LJ, II and Badr, KF "Glomerular actions of a free radical generated novel prostaglandin, 8-epi-prostaglandin F2 in the rat: Evidence for interaction with thromboxane A2 receptors." J. Clin. Invest., 90136-141, 1992.
• Takahashi, K, Nammour, T M, Fukunaga, M, Ebert, J, Morrow, J D, Roberts, L J, Hoover, R L, Badr, K F Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. J Clin Invest, 90(1), 136-41, 1992.
• Morrow, J D, Awad, J A, Oates, J A, Roberts, L J Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol, 98(5), 812-5, 1992.
• Morrow, JD, Awad, JA, Boss, HJ, Blair, IA, and Roberts, LJ, II "Non- cyclooxygenase derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids." Proc. Natl. Acad. Sci., 8910721-10725, 1992.
• Morrow, J D, Awad, J A, Boss, H J, Blair, I A, Roberts, L J Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci U S A, 89(22), 10721-5, 1992.
• Morrow, JD, Minton, TA, and Roberts, LJ, II "The F2-isoprostane, 8-epi-prostaglandin F2 , a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist." Prostaglandins, 44155-163, 1992.
• Morrow, J D, Minton, T A, Roberts, L J The F2-isoprostane, 8-epi-prostaglandin F2 alpha, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. Prostaglandins, 44(2), 155-63, 1992.
• Fink, R L, Roberts, L J, Scott, M The role of manometry, electromyography and radiology in the assessment of faecal incontinence. Aust N Z J Surg, 62(12), 951-8, 1992.
• Fink, R L, Roberts, L J, Scott, M The role of manometry, electromyography and radiology in the assessment of intractable constipation. Aust N Z J Surg, 62(12), 959-64, 1992.
• Morrow, JD, and Roberts, LJ, II ". Quantification of non-cyclooxygenase derived prostaglandins as a potential non-invasive marker of oxidative stress." Free Rad. Biol. Med., 10195-200, 1991.
• Morrow, J D, Prakash, C, Duckworth, T A, Zackert, W E, Blair, I A, Oates, J A, Roberts, L J A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. Adv Prostaglandin Thromboxane Leukot Res, 21A315-8, 1991.
• Roberts, LJ, Oates, JA Biochemical diagnosis of systemic mast cell disorders. J Invest Dermatol, 96(3 Suppl), 19S-24S; discussion 24S-25S; 60S-65S, 1991.
• Roberts, L J, Oates, J A Biochemical diagnosis of systemic mast cell disorders. J Invest Dermatol, 96(3), 19S-24S; discussion 24S-25S, 1991.
• Roberts, L J, Luke, D A, Rappaport, J, Seidman, E, Toro, P A, Reischl, T M Charting uncharted terrain: a behavioral observation system for mutual help groups. Am J Community Psychol, 19(5), 715-37, 1991.
• Roberts, L J Elective section after two sections--where's the evidence?. Br J Obstet Gynaecol, 98(12), 1199-202, 1991.
• Morrow, JD, Rowland, J, Margolies, G, and Roberts, LJ, II "Evidence that histamine is the causative toxin of scombroid fish poisoning." N. Engl. J. Med., 324716-720, 1991.
• Morrow, J D, Margolies, G R, Rowland, J, Roberts, L J Evidence that histamine is the causative toxin of scombroid-fish poisoning. N Engl J Med, 324(11), 716-20, 1991.
• Sladek, K, Sheller, J R, FitzGerald, G A, Morrow, J D, Roberts, L J Formation of PGD2 after allergen inhalation in atopic asthmatics. Adv Prostaglandin Thromboxane Leukot Res, 21A433-6, 1991.
• Morrow, J D, Hill, K E, Burk, R F, Nammour, T M, Badr, K F, Roberts, L J Formation of unique biologically active prostaglandins in vivo by a non-cyclooxygenase free radical catalyzed mechanism. Adv Prostaglandin Thromboxane Leukot Res, 21A125-8, 1991.
• Roberts, L J Idiopathic thrombocytopenic purpura in pregnancy: a randomized trial on the effect of antenatal low dose corticosteroids on neonatal platelet count. Br J Obstet Gynaecol, 98(3), 334-6, 1991.
• Duncan, B W, Harrison, M R, Zanjani, E D, Tarantal, A F, Adzick, N S, Bradley, S M, Longaker, M T, Jennings, R W, Roberts, L J, Bigler, M E Immunologic evaluation of hematopoietic chimeric rhesus monkeys. Transplant Proc, 23(1 Pt 1), 841-3, 1991.
• Atsmon, J, Freeman, M L, Meredith, M J, Sweetman, B J, Roberts, L J Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. Adv Prostaglandin Thromboxane Leukot Res, 21B887-90, 1991.
• Arzubiaga, C, Morrow, J, Roberts, L J, Biaggioni, I Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. J Allergy Clin Immunol, 87(1 Pt 1), 88-93, 1991.
• Morrow, J D, Roberts, L J Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress. Free Radic Biol Med, 10(3-4), 195-200, 1991.
• Morrow, J D, Prakash, C, Awad, J A, Duckworth, T A, Zackert, W E, Blair, I A, Oates, J A, Roberts, L J Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal Biochem, 193(1), 142-8, 1991.
• Roberts, L J, Young, K R The management of prolonged pregnancy--an analysis of women's attitudes before and after term. Br J Obstet Gynaecol, 98(11), 1102-6, 1991.
• Guzzo, C, Lavker, R, Roberts, L J, Fox, K, Schechter, N, Lazarus, G Urticaria pigmentosa. Systemic evaluation and successful treatment with topical steroids. Arch Dermatol, 127(2), 191-6, 1991.
• Morrow, JD, Hill, KE, Burk, RF, Nammour, TM, Badr, KF, and Roberts, LJ, II "A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase free radical catalyzed mechanism." Proc. Natl. Acad. Sci., USA, 879383-9387, 1990.
• Morrow, J D, Hill, K E, Burk, R F, Nammour, T M, Badr, K F, Roberts, L J A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A, 87(23), 9383-7, 1990.
• Atsmon, J, Freeman, M L, Meredith, M J, Sweetman, B J, Roberts, L J Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. Cancer Res, 50(6), 1879-85, 1990.
• Boh, E, Roberts, L J, Lieu, T S, Gammon, W R, Sontheimer, R D Epidermolysis bullosa acquisita preceding the development of systemic lupus erythematosus. J Am Acad Dermatol, 22(4), 587-93, 1990.
• Atsmon, J, Sweetman, B J, Baertschi, S W, Harris, T M, Roberts, L J Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. Biochemistry, 29(15), 3760-5, 1990.
• Hendin, B N, Longaker, M T, Finkbeiner, W E, Roberts, L J, Stern, R Hyaluronic acid deposition in cardiac myxomas: localization using a hyaluronate-specific binding protein. Am J Cardiovasc Pathol, 3(3), 209-15, 1990.
• Sebaldt, R J, Sheller, J R, Oates, J A, Roberts, L J, FitzGerald, G A Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proc Natl Acad Sci U S A, 87(18), 6974-8, 1990.
• Smith, W L, Borgeat, P, Hamberg, M, Roberts, L J, Willis, A l, Yamamoto, S, Ramwell, P W, Rokach, J, Samuelsson, B, Corey, E J Nomenclature. Methods Enzymol, 1871-9, 1990.
• Morrow, J D, Harris, T M, Roberts, L J Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Anal Biochem, 184(1), 1-10, 1990.
• Roberts, L J Premature ovarian failure and endometrial ablation. Br J Hosp Med, 44(5), 318, 1990.
• Wendelborn, D F, Morrow, J D, Roberts, L J Quantification of 9 alpha, 11 beta-prostaglandin F2 by stable isotope dilution mass spectrometric assay. Methods Enzymol, 18751-62, 1990.
• Smith, S, Anthony, L, Roberts, L J, Oates, J A, Pincus, T Resolution of musculoskeletal symptoms in the carcinoid syndrome after treatment with the somatostatin analog octreotide. Ann Intern Med, 112(1), 66-8, 1990.
• Dworski, R, Sheller, J R, Wickersham, N E, Oates, J A, Brigham, K L, Roberts, L J, Fitzgerald, G A Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am Rev Respir Dis, 139(1), 46-51, 1989.
• Fleck, R M, Barnadas, M, Schulz, W W, Roberts, L J, Freeman, R G Harlequin ichthyosis: an ultrastructural study. J Am Acad Dermatol, 21(5 Pt 1), 999-1006, 1989.
• Roberts, L J Long-term survival of a harlequin fetus. J Am Acad Dermatol, 21(2 Pt 2), 335-9, 1989.
• Morrow, J D, Parsons, W G, Roberts, L J Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins, 38(2), 263-74, 1989.
• Parsons, W G, Roberts, L J Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils: a potential mast cell-eosinophil interaction. Adv Prostaglandin Thromboxane Leukot Res, 19499-502, 1989.
• Arthur, H, Austin, L, Roberts, L J A pilot trial of plasma infusions in Duchenne muscular dystrophy. Aust Paediatr J, 24 Suppl 124-30, 1988.
• Roberts, L J Carcinoid syndrome and disorders of systemic mast-cell activation including systemic mastocytosis. Endocrinol Metab Clin North Am, 17(2), 415-36, 1988.
• Roberts, L J, Fink, C W Childhood polymyositis/dermatomyositis. Clin Dermatol, 6(2), 36-46, 49-51, 1988.
• Oates, J A, FitzGerald, G A, Branch, R A, Jackson, E K, Knapp, H R, Roberts, L J Clinical implications of prostaglandin and thromboxane A2 formation (1). N Engl J Med, 319(11), 689-98, 1988.
• Oates, J A, FitzGerald, G A, Branch, R A, Jackson, E K, Knapp, H R, Roberts, L J Clinical implications of prostaglandin and thromboxane A2 formation (2). N Engl J Med, 319(12), 761-7, 1988.
• Wendelborn, D F, Seibert, K, Roberts, L J Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. Proc Natl Acad Sci U S A, 85(2), 304-8, 1988.
• Rendon, M I, Roberts, L J, Tharp, M D Linear cutaneous lesions of Kaposi's sarcoma: a clinical clue to the diagnosis of acquired immunodeficiency syndrome. Arch Dermatol, 124(3), 327-9, 1988.
• Toro, P A, Reischl, T M, Zimmerman, M A, Rappaport, J, Seidman, E, Luke, D A, Roberts, L J Professionals in mutual help groups: impact on social climate and members' behavior. J Consult Clin Psychol, 56(4), 631-2, 1988.
• Dworski, R, Wendelborn, D F, Sheller, J R, FitzGerald, G A, Roberts, L J Prostaglandins in Ascaris antigen. J Allergy Clin Immunol, 82(3 Pt 1), 484, 1988.
• Soberman, R J, Sutyak, J P, Okita, R T, Wendelborn, D F, Roberts, L J, Austen, K F The identification and formation of 20-aldehyde leukotriene B4. J Biol Chem, 263(17), 7996-8002, 1988.
• Parsons, W G, Roberts, L J Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. J Immunol, 141(7), 2413-9, 1988.
• Seibert, K, Sheller, J R, Roberts, L J (5Z,13E)-(15S)-9 alpha,11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2): formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. Proc Natl Acad Sci U S A, 84(1), 256-60, 1987.
• Seibert, K, Sheller, J R, Roberts, L J 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. Adv Prostaglandin Thromboxane Leukot Res, 17A189-91, 1987.
• Roberts, L J, Sontheimer, R D Chronic bullous dermatosis of childhood: immunopathologic studies. Pediatr Dermatol, 4(1), 6-10, 1987.
• Wendelborn, D F, Seibert, K, Roberts, L J Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. Adv Prostaglandin Thromboxane Leukot Res, 17A47-9, 1987.
• Lynes, W L, Flynn, S D, Shortliffe, L D, Lemmers, M, Zipser, R, Roberts, L J, Stamey, T A Mast cell involvement in interstitial cystitis. J Urol, 138(4), 746-52, 1987.
• Roberts, L J, Seibert, K, Liston, T E, Tantengco, M V, Robertson, R M PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. Adv Prostaglandin Thromboxane Leukot Res, 17A427-9, 1987.
• Roberts, L J Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. Adv Prostaglandin Thromboxane Leukot Res, 17B608-10, 1987.
• Stier, C T, Roberts, L J, Wong, P Y Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. J Pharmacol Exp Ther, 243(2), 487-91, 1987.
• Watanabe, K, Iguchi, Y, Iguchi, S, Arai, Y, Hayaishi, O, Roberts, L J Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. Adv Prostaglandin Thromboxane Leukot Res, 17A44-6, 1987.
• Prakash, C, Roberts, L J, Saleh, S, Taber, D F, Blair, I A Synthesis of putative prostaglandin D2 metabolites. Adv Prostaglandin Thromboxane Leukot Res, 17B781-7, 1987.
• Roberts, L J, Shadwick, C F, Bergstresser, P R Zinc deficiency in two full-term breast-fed infants. J Am Acad Dermatol, 16(2 Pt 1), 301-4, 1987.
• Murray, J J, Tonnel, A B, Brash, A R, Roberts, L J, Gosset, P, Workman, R, Capron, A, Oates, J A Release of prostaglandin D2 into human airways during acute antigen challenge. N Engl J Med, 315(13), 800-4, 1986.
• Watanabe, K, Iguchi, Y, Iguchi, S, Arai, Y, Hayaishi, O, Roberts, L J Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. Proc Natl Acad Sci U S A, 83(6), 1583-7, 1986.
• Vire, G, Roberts, L J, King, L E Urticaria pigmentosa and natural sunlight. J Am Acad Dermatol, 14(4), 687-8, 1986.
• Massicot, J G, Soberman, R J, Ackerman, N R, Heavey, D, Roberts, L J, Austen, K F Workshop: Potential therapeutic uses of inhibitors of leukotriene generation and function. June 23, 1986, Bethesda, Maryland. Sponsored by the National Institute of Allergy and Infectious Diseases and the World Health Organization Collaborating Center for Allergic Diseases. Prostaglandins, 32(4), 481-94, 1986.
• Rappaport, J, Seidman, E, Toro, P A, McFadden, L S, Reischl, T M, Roberts, L J, Salem, D A, Stein, C H, Zimmerman, M A Collaborative research with a mutual help organization. Soc Policy, 15(3), 12-24, 1985.
• Roberts, L J, Aulsebrook, K A, Oates, J A Comparative evaluation of the radioenzymatic method for the determination of urinary histamine with a mass spectrometric assay. J Chromatogr, 338(1), 41-9, 1985.
• Forman, M B, Oates, J A, Robertson, D, Robertson, R M, Roberts, L J, Virmani, R Increased adventitial mast cells in a patient with coronary spasm. N Engl J Med, 313(18), 1138-41, 1985.
• Roberts, L J, Sweetman, B J Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins, 30(3), 383-400, 1985.
• Liston, T E, Roberts, L J Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J Biol Chem, 260(24), 13172-80, 1985.
• Liston, T E, Oates, J A, Roberts, L J Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. Adv Prostaglandin Thromboxane Leukot Res, 15365-7, 1985.
• Murray, J J, Tonnel, A B, Brash, A R, Roberts, L J, Gosset, P, Workman, R, Capron, A, Oates, J A Prostaglandin D2 is released during acute allergic bronchospasm in man. Trans Assoc Am Physicians, 98275-80, 1985.
• Liston, T E, Roberts, L J Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Proc Natl Acad Sci U S A, 82(18), 6030-4, 1985.
• Roberts, L J, Oates, J A Accurate and efficient method for quantification of urinary histamine by gas chromatography negative ion chemical ionization mass spectrometry. Anal Biochem, 136(1), 258-63, 1984.
• Roberts, L J Pentafluorobenzyl derivative of histamine for determination by gas chromatography-negative ion chemical ionization mass spectrometry. J Chromatogr, 287(1), 155-60, 1984.
• Roberts, L J Recurrent syncope due to systemic mastocytosis. Hypertension, 6(2 Pt 1), 285-94, 1984.
• FitzGerald, G A, Maas, R L, Lawson, J A, Oates, J A, Roberts, L J, Brash, A R Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man. Adv Prostaglandin Thromboxane Leukot Res, 11265-6, 1983.
• Roberts, L J, Ross, E Chronic airflow limitation. Nurse Pract, 8(10), 21, 24-5, 1983.
• Turk, J, Maas, R L, Roberts, L J, Brash, A R, Oates, J A Conjugated triene metabolites of arachidonic acid derived from dioxygenation at carbon-15: origin from eosinophil and mechanisms of biosynthesis. Adv Prostaglandin Thromboxane Leukot Res, 11123-32, 1983.
• FitzGerald, G A, Oates, J A, Hawiger, J, Maas, R L, Roberts, L J, Lawson, J A, Brash, A R Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest, 71(3), 676-88, 1983.
• Scott, H W, Parris, W C, Sandidge, P C, Oates, J A, Roberts, L J Hazards in operative management of patients with systemic mastocytosis. Ann Surg, 197(5), 507-14, 1983.
• Roberts, L J, Bloomgarden, Z T, Marney, S R, Rabin, D, Oates, J A Histamine release from a gastric carcinoid: provocation by pentagastrin and inhibition by somatostatin. Gastroenterology, 84(2), 272-5, 1983.
• Turk, J, Rand, T H, Maas, R L, Lawson, J A, Brash, A R, Roberts, L J, Colley, D G, Oates, J A Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils. Biochim Biophys Acta, 750(1), 78-90, 1983.
• Turk, J, Oates, J A, Roberts, L J Intervention with epinephrine in hypotension associated with mastocytosis. J Allergy Clin Immunol, 71(2), 189-92, 1983.
• Kootte, A M, Haak, A, Roberts, L J The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production. Neth J Med, 26(1), 18-20, 1983.
• Turk, J, Maas, R L, Brash, A R, Roberts, L J, Oates, J A Arachidonic acid 15-lipoxygenase products from human eosinophils. J Biol Chem, 257(12), 7068-76, 1982.
• Roberts, L J, Fields, J P, Oates, J A Mastocytosis without urticaria pigmentosa: a frequently unrecognized cause of recurrent syncope. Trans Assoc Am Physicians, 9536-41, 1982.
• Roberts, L J, Brash, A R, Oates, J A Metabolic fate of thromboxane A2 and prostacyclin. Adv Prostaglandin Thromboxane Leukot Res, 10211-25, 1982.
• Lewis, R A, Soter, N A, Diamond, P T, Austen, K F, Oates, J A, Roberts, L J Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J Immunol, 129(4), 1627-31, 1982.
• Roberts, L J Quantification of the PGD2 urinary metabolite 9 alpha-hydroxy-11, 15-dioxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid by stable isotope dilution mass spectrometric assay. Methods Enzymol, 86559-70, 1982.
• Maas, R L, Taber, D F, Roberts, L J Quantitative assay of urinary 2,3-dinor thromboxane B2 by GC-MS. Methods Enzymol, 86592-603, 1982.
• Roberts, L J, Turk, J W, Oates, J A Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks. Adv Shock Res, 8145-52, 1982.
• Roberts, L J, Sweetman, B J, Maas, R L, Hubbard, W C, Oates, J A Clinical application of PG and TX metabolite quantification. Prog Lipid Res, 20117-21, 1981.
• Fitzgerald, G A, Maas, R L, Stein, R, Oates, J A, Roberts, L J Intravenous prostacyclin in thrombotic thrombocytopenic purpura. Ann Intern Med, 95(3), 319-22, 1981.
• Roberts, L J, Sweetman, B J, Oates, J A Metabolism of thromboxane B2 in man. Identification of twenty urinary metabolites. J Biol Chem, 256(16), 8384-93, 1981.
• Lewis, R A, Holgate, S T, Roberts, L J, Oates, J A, Austen, K F Preferential generation of prostaglandin D2 by rat and human mast cells. Kroc Found Ser, 14239-54, 1981.
• Feely, J, Heidemann, H, Gerkens, J, Roberts, L J, Branch, R A Sodium depletion enhances nephrotoxicity of amphotericin B. Lancet, 1(8235), 1422-3, 1981.
• Robertson, R M, Robertson, D, Roberts, L J, Maas, R L, FitzGerald, G A, Friesinger, G C, Oates, J A Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. N Engl J Med, 304(17), 998-1003, 1981.
• Holgate, S T, Lewis, R A, Maguire, J F, Roberts, L J, Oates, J A, Austen, K F Effects of prostaglandin D2 on rat serosal mast cells: discordance between immunologic mediator release and cyclic AMP levels. J Immunol, 125(3), 1367-73, 1980.
• Roberts, L J, Sweetman, B J, Lewis, R A, Austen, K F, Oates, J A Increased production of prostaglandin D2 in patients with systemic mastocytosis. N Engl J Med, 303(24), 1400-4, 1980.
• Roberts, L J, Sweetman, B J, Lewis, R A, Folarin, V F, Austen, K F, Oates, J A Markedly increased synthesis of prostaglandin D2 in systemic mastocytosis. Trans Assoc Am Physicians, 93141-7, 1980.
• Oates, J A, Roberts, L J, Sweetman, B J, Maas, R L, Gerkens, J F, Taber, D F Metabolism of the prostaglandins and thromboxanes. Adv Prostaglandin Thromboxane Res, 635-41, 1980.
• Bertagna, X Y, Bloomgarden, Z T, Rabin, D, Roberts, L J, Orth, D N Molecular weight forms of immunoreactive calcitonin in a patient with medullary carcinoma of the thyroid: dynamic studies with calcium, pentagastrin and somatostatin. Clin Endocrinol (Oxf), 13(2), 115-23, 1980.
• Roberts, L J, Marney, S R, Oates, J A Blockade of the flush associated with metastatic gastric carcinoid by combined histamine H1 and H2 receptor antagonists. Evidence for an important role of H2 receptors in human vasculature. N Engl J Med, 300(5), 236-8, 1979.
• Lewis, R A, Holgate, S T, Roberts, L J, Maguire, J F, Oates, J A, Austen, K F Effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells. J Immunol, 123(4), 1663-8, 1979.
• Roberts, L J, Lewis, R A, Oates, J A, Austen, K F Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. Biochim Biophys Acta, 575(2), 185-92, 1979.
• Roberts, L J, Hubbard, W C, Bloomgarden, Z T, Bertagna, X Y, McKenna, T J, Rabinowitz, D, Oates, J A Prostaglandins: role in the humoral manifestations of medullary carcinoma of the thyroid and inhibition by somatostatin. Trans Assoc Am Physicians, 92286-91, 1979.
• Oelz, O, Knapp, H R, Roberts, L J, Oelz, R, Sweetman, B J, Oates, J A, Reed, P W Calcium-dependent stimulation of thromboxane and prostaglandin biosynthesis by ionophores. Adv Prostaglandin Thromboxane Res, 3147-58, 1978.
• Roberts, L J, Sweetman, B J, Oates, J A Metabolism of thromboxane B2 in the monkey. J Biol Chem, 253(15), 5305-18, 1978.
• Samuelsson, B, Hamberg, M, Roberts, L J, Oates, J A, Nelson, N A Nomenclature for thromboxanes. Prostaglandins, 16(6), 857-60, 1978.
• Roberts, L J, Sweetman, B J, Morgan, J L, Payne, N A, Oates, J A Identification of the major urinary metabolite of thromboxane B2 in the monkey. Prostaglandins, 13(4), 631-47, 1977.
• Knapp, H R, Oelz, O, Roberts, L J, Sweetman, B J, Oates, J A, Reed, P W Ionophores stimulate prostaglandin and thromboxane biosynthesis. Proc Natl Acad Sci U S A, 74(10), 4251-5, 1977.
• Roberts, L J, Sweetman, B J, Payne, N A, Oates, J A Metabolism of thromboxane B2 in man. Identification of the major urinary metabolite. J Biol Chem, 252(21), 7415-7, 1977.
• Duncan, G W, Roberts, L J, Wison, J P Paroxysmal hypertensive hemicrania. Headache, 17(1), 5-6, 1977.
• Ellis, E F, Oelz, O, Roberts, L J, Payne, N A, Sweetman, B J, Nies, A S, Oates, J A Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2. Science, 193(4258), 1135-7, 1976.
• Wait, B, Blair, R, Roberts, L J Energy intake of well-nourished children and adolescents. Am J Clin Nutr, 22(10), 1383-96, 1969.
• Fernández, N A, Burgos, J C, Roberts, L J, Asenjo, C F Nutritional status in Puerto Rican slum area. Am J Clin Nutr, 21(6), 646-56, 1968.
• Fernández, N A, Burgos, J C, Roberts, L J, Asenjo, C F Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Montones 4, Las Piedras. J Am Diet Assoc, 53(2), 119-26, 1968.
• Fernández, N A, Burgos, J C, Roberts, L J, Asenjo, C F Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Masas 2, Gurabo, Puerto Rico. Bol Asoc Med P R, 59(12), 503-14, 1967.
• Fernández, N A, Burgos, J C, Plough, I C, Roberts, L J, Asenjo, C F Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Naranjo, Moca, Puerto Rico. Am J Clin Nutr, 19(4), 269-84, 1966.
• Fernández, NA, Burgos, JC, Plough, IC, Roberts, LJ, Asenjo, CF Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Mavilla, Vega Alta, Puerto Rico. Am J Clin Nutr, 17(5), 305-16, 1965.
• ROBERTS, LJ A COOPERATIVE NUTRITION RESEARCH PROGRAM FOR PUERTO RICO. I. BACKGROUND AND GENERAL PLAN. J Am Diet Assoc, 4418-21, 1964.
• PLOUGH, IC, FERNANDEZLOPEZ, NA, ANGEL, CR, ROBERTS, LJ A NUTRITION SURVEY OF THREE RURAL PUERTO RICAN COMMUNITIES. Bol Asoc Med P R, 55SUPPL:1-51, 1963.
• ROBERTS, LJ Beginnings of the recommended dietary allowances. J Am Diet Assoc, 34(9), 903-8, 1958.
• ROBERTS, LJ A basic food pattern for Puerto Rico. J Am Diet Assoc, 30(11), 1097-100, 1954.
• ROBERTS, LJ A practical nutrition program for Puerto Rico. Nutr Rev, 8(11), 321-4, 1950.
• King, CG, Eddy, WH, Heseltine, MM, Hunscher, HA, Mitchell, HS, Remington, RE, Roberts, LJ, Sebrell, WH, Sedgwick, J Report of the Committee on Nutritional Problems (Nutrition as a Science in Wartime) : Food and Nutrition Section. Am J Public Health Nations Health, 34(7), 774-9, 1944.
• Shepard, WP, Atwater, RM, Freeman, AW, Godfrey, ES, Gordon, JE, Hiscock, IV, McIver, P, Ramsey, GH, Smillie, WG, Tarbett, RE, Vaughan, HF, Baker, JN, Blood, AF, Dimond, B, Heseltine, MM, Koehne, M, Roberts, LJ, Sebrell, WH Minimum Qualifications for Nutritionists in Health Agencies : Subcommittee on the Educational Qualifications of Public Health Nutritionists. Am J Public Health Nations Health, 31(5), 494-7, 1941.
• Roberts, LJ TEACHING CHILDREN TO LIKE WHOLESOME FOODS. Am J Public Health (N Y), 15(1), 52-3, 1925.

Education

• M.D. - University of Wisconsin
• Fellowship - Vanderbilt University Medical Center
• Internship - Denver General Hospital
• Post Graduate Training - Barnes-Jewish Hospital, Washington University Medical Center
• Post Graduate Training - Vanderbilt University Medical Center
• Residency - Washington University Medical Center
• Internship - Aurora Saint Luke's Medical Center
• Residency - Vanderbilt University Medical Center