The VICC.ORG Investigator Directory

Jennifer M. Giltnane, M.D., Ph.D

Instructor in Pathology, Microbiology and Immunology
VICC Member

Patient Contact Information:

615-936-1925

Healthcare Provider Contact Information:

2220 Pierce Avenue
649 Preston Research Building
Nashville, TN 37232
865-566-6505
Fax: 615-936-1790

Profile

Dr. Giltnane is a junior faculty breast pathologist with a special interest in diagnostic quality improvement for the management and treatment of breast disease. She has research expertise in the development genomic and proteomic biomarkers for diagnosis, prediction, and prognosis in breast cancer as well as clinical expertise in the processing of tissue specimens and biobanking.  She is currently supported by the Department of Pathology, Microbiology, and Immunology to pursue post-doctoral training in the laboratory of Carlos Artega, M.D., focused on translational research technologies including next-generation sequencing toward the improvement of outcomes in breast cancer.

Research Specialty:

Predictive biomarker discovery and validation for translational oncology research

Research Description:

I am continuing my career at Vanderbilt with a focus on biomarker discovery and validation for the prediction of treatment resistance and recurrence in breast cancer. Currently, I am exploring the mechanisms of resistance to endocrine therapy, utilizing the accrued tissue in the BRE0776 presurgical letrozole trial as part of the VICC's Breast SPORE. Through multi-platform molecular profiling of these tumors, I hope to identify actionable somatic alterations and uncover additional therapeutic liabilities to overcome endocrine resistance in early breast cancer. A long-term goal is to develop a cost-effective, protein-based biomarker assay to predict endocrine-response in ER+ breast cancer, informed by my experience with quantitative protein measurements in tissue.

Clinical Interest:

Biobanking and tissue management for clinical studies, tissue microarray studies of clinical trial cohorts

Publications:

Education

  • MD, Yale University School of Medicine, 2008   
  • PhD, Yale University Graduate School of Arts & Sciences (Experimental Pathology), 2008 
  • Residency, Anatomic and Clinical Pathology, Vanderbilt University Medical Center, 2012

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