Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

Punita Dhawan, Ph.D.

See also:

• Host Tumor Interactions Research Program
• Surgery
• BRET: Biomedical Research Education & Training Faculty Listing

Assistant Professor
VICC Member
Researcher

Contact Information:

Vanderbilt University Medical Center
D-2300 MCN
Nashville, TN 37232-2733
615-322-4755
Fax: 615-322-6174

Publications:

• Smith, JJ, Deane, NG, Dhawan, P, Beauchamp, RD Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery, 144(3), 353-66, 2008.
• Dhawan, P, Su, Y, Thu, YM, Yu, Y, Baugher, P, Ellis, DL, Sobolik-Delmaire, T, Kelley, M, Cheung, TC, Ware, CF, Richmond, A The Lymphotoxin-{beta} Receptor Is an Upstream Activator of NF-{kappa}B-mediated Transcription in Melanoma Cells. J Biol Chem, 283(22), 15399-15408, 2008.
• Singh, AB, Sugimoto, K, Dhawan, P, Harris, RC Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Am J Physiol Cell Physiol, 293(5), C1660-8, 2007.
• Shiou, SR, Singh, AB, Moorthy, K, Datta, PK, Washington, MK, Beauchamp, RD, Dhawan, P Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9, 2007.
• Shiou, SR, Datta, PK, Dhawan, P, Law, BK, Yingling, JM, Dixon, DA, Beauchamp, RD Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem, 281(45), 33971-81, 2006.
• Dhawan, P, Singh, AB, Deane, NG, No, Y, Shiou, SR, Schmidt, C, Neff, J, Washington, MK, Beauchamp, RD Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76, 2005.
• Dhawan P, Singh AB, Ellis DL, Richmond A. "Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression." Cancer Res. , (24): (Dec 15;62), 7335-42., 2002 .
• Dhawan P, Richmond A. "A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells.." J Biol Chem. , 10: (Mar 8; 277), 7920-8. , 2002.
• Dhawan, P, Singh, AB, Ellis, DL, Richmond, A Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res, 62(24), 7335-42, 2002.
• Dhawan P, Richmond A "Role of CXCL1 in tumorigenesis of melanoma." J Leukoc Biol. , Jul; 72(1): 9-18., 2002.
• Nirodi, C, Hart, J, Dhawan, P, Moon , NS, Nepveu, A, Richmond, A The role of CDP in the negative regulation of CXCL1 gene expression. J Biol Chem, 276(28), 26122-31, 2001.
• Dhawan P, Bell A, Kumar A, Golden C, Mehta KD "Critical role of p42/44(MAPK) activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf-1/Mek-1/p42/44(MAPK) cascade alone is sufficient to induce LDL receptor expression." J Lipid Res. , (10): (Oct; 40), 1911-9. , 1999.
• Singh RP, Dhawan P, Golden C, Kapoor GS, Mehta KD "One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade." J Biol Chem. ., (28): (Jul 9; 274), 19593-600, 1999.
• Dhawan P, Yang E, Kumar A, Mehta KD "Genetic complexity of the human geranylgeranyltransferase I beta-subunit gene: a multigene family of pseudogenes derived from mis-spliced transcripts.." Gene. , (1): (Mar 27;), 2109-15. , 1998.
• Dhawan P, Chang R, Mehta KD. "Identification of essential nucleotides of the FP1 element responsible for enhancement of low density lipoprotein receptor gene transcription.." Nucleic Acids Res. , (20): (Oct 15; 25), 4132-8., 1997.
• Kumar A, Beresini MH, Dhawan P, Mehta KD. "Alpha-subunit of farnesyltransferase is phosphorylated in vivo: effect of protein phosphatase-1 on enzymatic activity.." Biochem Biophys Res Commun. , 222(2): (May 15;), 445-52, 1996.
• Nirodi C, Hart J, Dhawan P, Moon NS, Nepveu A, Richmond A. "The role of CDP in the negative regulation of CXCL1 gene expression." J Biol Chem. , 276(28(Jul 13;), 26122-31. , 2001.