Richard Peek, Jr. : Directory - Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

Richard Peek, Jr., M.D.

Director, Gastroenterology, Hepatology & Nutrition
Professor of Medicine (Gastroenterology, Hepatology, & Nutrition)
Professor of Cancer Biology
VICC Member
Researcher

Patient Contact Information:

615-322-0128

Healthcare Provider Contact Information:

Vanderbilt University Medical Center
1161 21st Ave., S. C-2104 MCN
Nashville, TN 37232-2279
615-322-8979

Research Specialty:

Pathogenesis of Helicobacter pylori infection and gastric cancer

Research Description:

The gastrointestinal tract is a dynamic interactive barrier that normally segregates microbial populations from their cognate human hosts. An aberrant consequence of contact between microbes and gut epithelial cells is the development of mucosal inflammation, which, if allowed to become persistent, can initiate carcinogenic pathways. Gastric adenocarcinoma is the second leading cause of cancer-related death in the world, and Helicobacter pylori, a bacterial species that persistently colonizes the human stomach and induces chronic gastritis, is the strongest known risk factor for this malignancy. However, only a fraction of infected persons ever develop cancer, underscoring the importance of defining mechanisms that regulate the biological interactions of H. pylori with their hosts that promote neoplastic transformation. Adherence of H. pylori to gastric epithelial cells is critical for induction of inflammation and injury; therefore, the overarching theme for our research has been delineation of the molecular signaling events initiated by bacterial:epithelial cell contact that regulate phenotypes related to carcinogenesis.

The most important known H. pylori strain-specific determinant associated with cancer is the cag pathogenicity island, and cag+ strains augment the risk for severe gastritis and gastric cancer. Using in vitro models of bacterial:gastric epithelial cell interactions, we have shown that cag island genes are required for pro-inflammatory cytokine release and induction of apoptosis, and that these events are mediated by activation of NF-kB and/or mitogen-activated protein kinases (MAPK). Recently, we have used global proteomics approaches to identify additional H. pylori products that are related to pathogenesis within the gastric niche. Extending these results into rodent models of H. pylori-induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag+ compared to cag- strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer. Therefore, we have also focused our investigations on host determinants that influence disease outcomes occurring within the context of H. pylori infection. One host effector that may influence carcinogenesis in response to H. pylori is MMP-7, a matrix metalloproteinase that enhances tumor formation in rodents, and is over-expressed in premalignant and malignant lesions within H. pylori-infected human mucosa. Although epithelial cells acutely exposed to matrilysin rapidly undergo apoptosis, constitutive expression of MMP-7 selects for cells with a reduced sensitivity to apoptosis. Our experiments have recently shown that MMP-7 is detected exclusively in human mucosa colonized by cag+ strains, and these same H. pylori strains selectively induce MMP-7 in vitro through cag-mediated activation of NF-kB and MAPK. Based upon these data, we hypothesize that strain-selective activation of NF-kB and/or MAPK by H. pylori cag+ strains regulates MMP-7 expression, which may contribute to the augmentation in carcinogenic risk associated with these strains by attenuating apoptosis within chronically colonized mucosa.

We have also recently shown that carcinogenic strains of H. pylori can selectively activate B-catenin, and this is due to translocation of CagA into the host epithelial cell. Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori-induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

Publications:

Loh, JT, Friedman, DB, Piazuelo, MB, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, Cover, TL Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression. Infect Immun, 2012.
Yan, F, Wang, L, Shi, Y, Cao, H, Liu, L, Washington, MK, Chaturvedi, R, Israel, DA, Cao, H, Wang, B, Peek, RM, Wilson, KT, Polk, DB Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol, 302(5), G504-14, 2012.
Sitaraman, R, Israel, DA, Romero-Gallo, J, Peek, RM Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties. J Clin Microbiol, 50(3), 1014-8, 2012.
Takeuchi, H, Zhang, YN, Israel, DA, Peek, RM, Kamioka, M, Yanai, H, Morimoto, N, Sugiura, T Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation. World J Gastroenterol, 18(5), 425-34, 2012.
Peek, RM, Kuipers, EJ Gained in translation: the importance of biologically relevant models of Helicobacter pylori-induced gastric cancer. Gut, 61(1), 2-3, 2012.
Sicinschi, LA, Correa, P, Bravo, LE, Peek, RM, Wilson, KT, Loh, JT, Yepez, MC, Gold, BD, Thompson, DT, Cover, TL, Schneider, BG Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter, 17(2), 96-106, 2012.
Raju, D, Hussey, S, Ang, M, Terebiznik, MR, Sibony, M, Galindo-Mata, E, Gupta, V, Blanke, SR, Delgado, A, Romero-Gallo, J, Ramjeet, MS, Mascarenhas, H, Peek, RM, Correa, P, Streutker, C, Hold, G, Kunstmann, E, Yoshimori, T, Silverberg, MS, Girardin, SE, Philpott, DJ, El Omar, E, Jones, NL Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology, 142(5), 1160-71, 2012.
Wroblewski, LE, Peek, RM "Targeted disruption of the epithelial-barrier by Helicobacter pylori". Cell Commun Signal, 9(1), 29, 2011.
Yachimski, P, Peek, RM Biomarkers in exploring the frontiers of diagnosis, prognosis, and therapy of Barrett''s esophagus. Cancer Prev Res (Phila), 4(6), 783-6, 2011.
Yan, F, Cao, H, Cover, TL, Washington, MK, Shi, Y, Liu, L, Chaturvedi, R, Peek, RM, Wilson, KT, Polk, DB Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest, 121(6), 2242-53, 2011.
Gobert, AP, Asim, M, Piazuelo, MB, Verriere, T, Scull, BP, de Sablet, T, Glumac, A, Lewis, ND, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. J Immunol, 187(10), 5370-9, 2011.
Nagy, TA, Allen, SS, Wroblewski, LE, Flaherty, DK, Slaughter, JC, Perez-Perez, G, Israel, DA, Peek, RM Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am J Pathol, 178(4), 1448-52, 2011.
Tan, S, Noto, JM, Romero-Gallo, J, Peek, RM, Amieva, MR Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. PLoS Pathog, 7(5), e1002050, 2011.
Soutto, M, Belkhiri, A, Piazuelo, MB, Schneider, BG, Peng, D, Jiang, A, Washington, MK, Kokoye, Y, Crowe, SE, Zaika, A, Correa, P, Peek, RM, El-Rifai, W Loss of TFF1 is associated with activation of NF-ÎºB-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest, 121(5), 1753-67, 2011.
de Sablet, T, Piazuelo, MB, Shaffer, CL, Schneider, BG, Asim, M, Chaturvedi, R, Bravo, LE, Sicinschi, LA, Delgado, AG, Mera, RM, Israel, DA, Romero-Gallo, J, Peek, RM, Cover, TL, Correa, P, Wilson, KT Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, 60(9), 1189-95, 2011.
Epplein, M, Signorello, LB, Zheng, W, Peek, RM, Michel, A, Williams, SM, Pawlita, M, Correa, P, Cai, Q, Blot, WJ Race, African ancestry, and Helicobacter pylori infection in a low-income United States population. Cancer Epidemiol Biomarkers Prev, 20(5), 826-34, 2011.
Chaturvedi, R, Asim, M, Romero-Gallo, J, Barry, DP, Hoge, S, de Sablet, T, Delgado, AG, Wroblewski, LE, Piazuelo, MB, Yan, F, Israel, DA, Casero, RA, Correa, P, Gobert, AP, Polk, DB, Peek, RM, Wilson, KT Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology, 141(5), 1696-708.e1-2, 2011.
Hilliard, VC, Frey, MR, Dempsey, PJ, Peek, RM, Polk, DB TNF-alpha converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol, 301(2), G338-46, 2011.
Nagy, TA, Wroblewski, LE, Wang, D, Piazuelo, MB, Delgado, A, Romero-Gallo, J, Noto, J, Israel, DA, Ogden, SR, Correa, P, Cover, TL, Peek, RM Î²-Catenin and p120 mediate PPARÎ´-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology, 141(2), 553-64, 2011.
Sicinschi, LA, Correa, P, Peek, RM, Camargo, MC, Piazuelo, MB, Romero-Gallo, J, Hobbs, SS, Krishna, U, Delgado, A, Mera, R, Bravo, LE, Schneider, BG CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect, 16(4), 369-78, 2010.
Miles, S, Piazuelo, MB, Semino-Mora, C, Washington, MK, Dubois, A, Peek, RM, Correa, P, Merrell, DS Detailed in vivo analysis of the role of Helicobacter pylori Fur in colonization and disease. Infect Immun, 78(7), 3073-82, 2010.
Styer, CM, Hansen, LM, Cooke, CL, Gundersen, AM, Choi, SS, Berg, DE, Benghezal, M, Marshall, BJ, Peek, RM, BorÃ©n, T, Solnick, JV Expression of the BabA adhesin during experimental infection with Helicobacter pylori. Infect Immun, 78(4), 1593-600, 2010.
Tsang, YH, Lamb, A, Romero-Gallo, J, Huang, B, Ito, K, Peek, RM, Ito, Y, Chen, LF Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation. Oncogene, 29(41), 5643-50, 2010.
Wroblewski, LE, Peek, RM, Wilson, KT Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev, 23(4), 713-39, 2010.
Saha, A, Hammond, CE, Beeson, C, Peek, RM, Smolka, AJ Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa. Gut, 59(7), 874-81, 2010.
Ogden, SR, Noto, JM, Allen, SS, Patel, DA, Romero-Gallo, J, Washington, MK, Fingleton, B, Israel, DA, Lewis, ND, Wilson, KT, Chaturvedi, R, Zhao, Z, Shyr, Y, Peek, RM Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res, 70(1), 30-5, 2010.
Nam, KT, Lee, HJ, Sousa, JF, Weis, VG, O''Neal, RL, Finke, PE, Romero-Gallo, J, Shi, G, Mills, JC, Peek, RM, Konieczny, SF, Goldenring, JR Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology, 139(6), 2028-2037.e9, 2010.
Schneider, BG, Peng, DF, Camargo, MC, Piazuelo, MB, Sicinschi, LA, Mera, R, Romero-Gallo, J, Delgado, AG, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, El-Rifai, W Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer, 127(11), 2588-97, 2010.
Wei, J, Nagy, TA, Vilgelm, A, Zaika, E, Ogden, SR, Romero-Gallo, J, Piazuelo, MB, Correa, P, Washington, MK, El-Rifai, W, Peek, RM, Zaika, A Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology, 139(4), 1333-43, 2010.
Peek, RM, Fiske, C, Wilson, KT Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol Rev, 90(3), 831-58, 2010.
Nam, KT, Lee, HJ, Mok, H, Romero-Gallo, J, Crowe, JE, Peek, RM, Goldenring, JR Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology, 136(4), 1288-96, 2009.
Franco, AT, Friedman, DB, Nagy, TA, Romero-Gallo, J, Krishna, U, Kendall, A, Israel, DA, Tegtmeyer, N, Washington, MK, Peek, RM Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics, 8(8), 1947-58, 2009.
Yan, F, Cao, H, Chaturvedi, R, Krishna, U, Hobbs, SS, Dempsey, PJ, Peek, RM, Cover, TL, Washington, MK, Wilson, KT, Polk, DB Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology, 136(4), 1297-1307, e1-3, 2009.
McClain, MS, Shaffer, CL, Israel, DA, Peek, RM, Cover, TL Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics, 103, 2009.
Lamb, A, Yang, XD, Tsang, YH, Li, JD, Higashi, H, Hatakeyama, M, Peek, RM, Blanke, SR, Chen, LF Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep, 10(11), 1242-9, 2009.
Bronte-Tinkew, DM, Terebiznik, M, Franco, A, Ang, M, Ahn, D, Mimuro, H, Sasakawa, C, Ropeleski, MJ, Peek, RM, Jones, NL Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res, 69(2), 632-9, 2009.
Wroblewski, LE, Shen, L, Ogden, S, Romero-Gallo, J, Lapierre, LA, Israel, DA, Turner, JR, Peek, RM Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology, 136(1), 236-46, 2009.
Nagy, TA, Frey, MR, Yan, F, Israel, DA, Polk, DB, Peek, RM Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis, 199(5), 641-51, 2009.
Yang, L, Lu, X, Nossa, CW, Francois, F, Peek, RM, Pei, Z Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology, 137(2), 588-97, 2009.
Algood, HM, Allen, SS, Washington, MK, Peek, RM, Miller, GG, Cover, TL Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J Immunol, 183(9), 5837-46, 2009.
Schneider, N, Krishna, U, Romero-Gallo, J, Israel, DA, Piazuelo, MB, Camargo, MC, Sicinschi, LA, Schneider, BG, Correa, P, Peek, RM Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential. J Infect Dis, 199(8), 1218-21, 2009.
Romero-Gallo, J, Harris, EJ, Krishna, U, Washington, MK, Perez-Perez, GI, Peek, RM Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab Invest, 88(3), 328-36, 2008.
Piazuelo, MB, Camargo, MC, Mera, RM, Delgado, AG, Peek, RM, Correa, H, Schneider, BG, Sicinschi, LA, Mora, Y, Bravo, LE, Correa, P Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis. Hum Pathol, 2008.
Goodwin, AC, Weinberger, DM, Ford, CB, Nelson, JC, Snider, JD, Hall, JD, Paules, CI, Peek, RM, Forsyth, MH Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system. Microbiology, 154(Pt 8), 2231-40, 2008.
Ding, SZ, Olekhnovich, IN, Cover, TL, Peek, RM, Smith, MF, Goldberg, JB Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells. FEMS Immunol Med Microbiol, 53(3), 385-94, 2008.
Sicinschi, LA, Correa, P, Peek, RM, Camargo, MC, Delgado, A, Piazuelo, MB, Romero-Gallo, J, Bravo, LE, Schneider, BG Helicobacter pylori genotyping and sequencing using paraffin-embedded biopsies from residents of colombian areas with contrasting gastric cancer risks. Helicobacter, 13(2), 135-45, 2008.
Keates, AC, Tummala, S, Peek, RM, Csizmadia, E, Kunzli, B, Becker, K, Correa, P, Romero-Gallo, J, Piazuelo, MB, Sheth, S, Kelly, CP, Robson, SC, Keates, S Helicobacter pylori infection stimulates plasminogen activator inhibitor-1 (PAI-1) production by gastric epithelial cells. Infect Immun, 2008.
Shimada, M, Ando, T, Peek, RM, Watanabe, O, Ishiguro, K, Maeda, O, Ishikawa, D, Hasegawa, M, Ina, K, Ohmiya, N, Niwa, Y, Goto, H Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cells. Eur J Gastroenterol Hepatol, 20(12), 1144-50, 2008.
Wei, J, O''Brien, D, Vilgelm, A, Piazuelo, MB, Correa, P, Washington, MK, El-Rifai, W, Peek, RM, Zaika, A Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology, 134(5), 1412-23, 2008.
Franco, AT, Johnston, E, Krishna, U, Yamaoka, Y, Israel, DA, Nagy, TA, Wroblewski, LE, Piazuelo, MB, Correa, P, Peek, RM Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res, 68(2), 379-87, 2008.
O''Brien, DP, Romero-Gallo, J, Schneider, BG, Chaturvedi, R, Delgado, A, Harris, EJ, Krishna, U, Ogden, SR, Israel, DA, Wilson, KT, Peek, RM Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J Biol Chem, 283(35), 23922-30, 2008.
Steele, IA, Dimaline, R, Pritchard, DM, Peek, RM, Wang, TC, Dockray, GJ, Varro, A Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. Am J Physiol Gastrointest Liver Physiol, 293(1), G347-54, 2007.
Murata-Kamiya, N, Kurashima, Y, Teishikata, Y, Yamahashi, Y, Saito, Y, Higashi, H, Aburatani, H, Akiyama, T, Peek, RM, Azuma, T, Hatakeyama, M Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene, 26(32), 4617-26, 2007.
Keates, S, Keates, AC, Katchar, K, Peek, RM, Kelly, CP Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis, 196(1), 95-103, 2007.
Algood, HM, Gallo-Romero, J, Wilson, KT, Peek, RM, Cover, TL Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol, 51(3), 577-86, 2007.
Wroblewski, LE, Peek, RM Orchestration of dysregulated epithelial turnover by a manipulative pathogen. Cell Host Microbe, 2(4), 209-11, 2007.
Ghose, C, Perez-Perez, GI, Torres, VJ, Crosatti, M, Nomura, A, Peek, RM, Cover, TL, Francois, F, Blaser, MJ Serological assays to identify human gastric colonization by VacA m1 or m2 Helicobacter pylori strains. Clin Vaccine Immunol, 2007.
Corcoran, PA, Atherton, JC, Kerrigan, SW, Wadstrom, T, Murray, FE, Peek, RM, Fitzgerald, DJ, Cox, DM, Byrne, MF The effect of different strains of Helicobacter pylori on platelet aggregation. Can J Gastroenterol, 21(6), 367-70, 2007.
Peek, RM, Schneider, BG, Correa, P Coming unglued. Clin Cancer Res, 12(10), 2951-4, 2006.
Peek, RM, Crabtree, JE Helicobacter infection and gastric neoplasia. J Pathol, 208(2), 233-48, 2006.
Camargo, MC, Mera, R, Correa, P, Peek, RM, Fontham, ET, Goodman, KJ, Piazuelo, MB, Sicinschi, L, Zabaleta, J, Schneider, BG Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 15(9), 1674-87, 2006.
O''Brien, DP, Israel, DA, Krishna, U, Romero-Gallo, J, Nedrud, J, Medof, ME, Lin, F, Redline, R, Lublin, DM, Nowicki, BJ, Franco, AT, Ogden, S, Williams, AD, Polk, DB, Peek, RM The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem, 281(19), 13317-23, 2006.
Israel, DA, Peek, RM The role of persistence in Helicobacter pylori pathogenesis. Curr Opin Gastroenterol, 22(1), 3-7, 2006.
Franco, AT, Israel, DA, Washington, MK, Krishna, U, Fox, JG, Rogers, AB, Neish, AS, Collier-Hyams, L, Perez-Perez, GI, Hatakeyama, M, Whitehead, R, Gaus, K, Obrien, DP, Romero-Gallo, J, Peek, RM Activation of {beta}-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A, 102(30); Epub Jul 18(7/26/05), 10646-51, 2005.
Pei, Z, Yang, L, Peek, RM, Jr Levine, SM, Pride, DT, Blaser, MJ Bacterial biota in reflux esophagitis and Barrett''s esophagus. World J Gastroenterol, 11(46), 7277-83, 2005.
Peek, RM Events at the host-microbial interface of the gastrointestinal tract IV. The pathogenesis of Helicobacter pylori persistence. Am J Physiol Gastrointest Liver Physiol, 289(1), G8-12, 2005.
Nomura, S, Settle, SH, Leys, CM, Means, AL, Peek, RM, Leach, SD, Wright, CV, Coffey, RJ, Goldenring, JR Evidence for repatterning of the gastric fundic epithelium associated with MÃ©nÃ©trier's disease and TGFalpha overexpression. Gastroenterology, 128(5), 1292-305, 2005.
Terry, CE, McGinnis, LM, Madigan, KC, Cao, P, Cover, TL, Liechti, GW, Peek, RM, Forsyth, MH Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains. Infect Immun, 73(6), 3794-8, 2005.
Popescu, A, Karpay, A, Israel, DA, Peek, RM, Krezel, AM Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators. Proteins, 59(2), 303-11, 2005.
Peek, RM, Mohla, S, DuBois, RN Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting. Cancer Res, 65(19), 8583-6, 2005.
Mizuno, T, Ando, T, Nobata, K, Tsuzuki, T, Maeda, O, Watanabe, O, Minami, M, Ina, K, Kusugami, K, Peek, RM, Goto, H Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization. World J Gastroenterol, 11(40), 6305-11, 2005.
Bhat, N, Gaensbauer, J, Peek, RM, Bloch, K, Tham, KT, Blaser, MJ, Perez-Perez, G Local and systemic immune and inflammatory responses to Helicobacter pylori strains. Clin Diagn Lab Immunol, 12(12), 1393-400, 2005.
Peek RM. "Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA.." Science STKE, 2771-3, 2005.
Peek, RM Pathogenesis of Helicobacter pylori infection. Springer Semin Immunopathol, 2005.
Backert, S, Kwok, T, Schmid, M, Selbach, M, Moese, S, Peek, RM, KÃ¶nig, W, Meyer, TF, Jungblut, PR Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics, 5(5), 1331-45, 2005.
Keates S, Keates A, Nath S, Peek RM, & Kelly CP "Transactivation of the EGFR by cag+ Helicobacter pylori induces up-regulation of the early growth response gene Egr-1 in gastric epithelial cells.." Gut, 541363-1369, 2005.
Peek RM. "Molecular hijacking and intracellular chaos.." Gastroenterology, 126613-614, 2004.
Duck WM, Sobel J, Pruckler JM, Song Q, Swerdlow D, Friedman C, Sulka A, Swaminathan B, Taylor T, Hoestra M, Griffin P, Smoot D, Peek RM, Metz DC, Bloom PB, Goldschmidt S, Dunne D, Parsonnet J, Triadafilopoulos G, Perez-Perez GI, Cutler A, Vakil N, Ernst P, Czinn S, and Gold BD "Antimicrobial resistance rates and risk factors for antimicrobial resistance in Helicobacter pylori infection in a prospective multi-center study in the United States.." Emerging Infectious Diseases, 101088-1094, 2004.
Peek, RM Clandestine intracellular delivery of Helicobacter pylori CagA: guess who''s coming to dinner. Gastroenterology, 127(2), 669-72, 2004.
Peek, RM Eradication of Helicobacter pylori as a means towards eliminating gastric adenocarcinoma. Gastroenterology, 127(1), 344-6, 2004.
Peek, Richard Helicobacter pylori and Gastroesophageal Reflux Disease. Curr Treat Options Gastroenterol, 7(1), 59-70, 2004.
Gewirtz, AT, Yu, Y, Krishna, US, Israel, DA, Lyons, SL, Peek, RM Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J Infect Dis, 189(10), 1914-20, 2004.
Peek RM. "Intestinal malignancy and Campylobacter jejuni.." Gastroenterology, 1271266-1267, 2004.
Peek, RM Intestinal malignancy and campylobacter jejuni. Gastroenterology, 127(4), 1266-7; discussion 1267-8, 2004.
Peek, RM Molecular hijacking and intracellular chaos. Gastroenterology, 126(2), 613-4; discussion 614-5, 2004.
McNulty, SL, Mole, BM, Dailidiene, D, Segal, I, Ally, R, Mistry, R, Secka, O, Adegbola, RA, Thomas, JE, Lenarcic, EM, Peek, RM, Berg, DE, Forsyth, MH Novel 180- and 480-base-pair insertions in African and African-American strains of Helicobacter pylori. J Clin Microbiol, 42(12), 5658-63, 2004.
Peek, RM Preventing colitis through alteration of the intestinal biota. Gastroenterology, 126(1), 353-5; discussion 355, 2004.
Peek, RM Prevention of colorectal cancer through the use of COX-2 selective inhibitors. Cancer Chemother Pharmacol, 54 Suppl 1S50-6, 2004.
Peek, RM The past determines the future. Gastroenterology, 126(4), 1202-4, 2004.
Israel DA and Peek RM. "Application of microarray analysis to the investigation of host-pathogen interactions.." In: Hecht GA, editor. Microbial pathogenesis and the intestinal epithelial cell. ASM press, Washington D.C. , 121-140, 2003.
Lamarque D and Peek RM. "Helicobacter pylori pathogenesis.." Helicobacter, 821-30, 2003.
Crawford, HC, Krishna, US, Israel, DA, Matrisian, LM, Washington, MK, Peek, RM Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology, 125(4), 1125-36, 2003.
Fox, JG, Wang, TC, Rogers, AB, Poutahidis, T, Ge, Z, Taylor, N, Dangler, CA, Israel, DA, Krishna, U, Gaus, K, Peek, RM Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology, 124(7), 1879-90, 2003.
Cover, Timothy L, Krishna, Uma S, Israel, Dawn A, Peek, Richard M Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res, 63(5), 951-7, 2003.
Peek, RM Intoxicated cells and stomach ulcers. Nat Genet, 33(3), 328-30, 2003.
Aras RA, Lee Y-C, Peek RM, and Blaser MJ "Natural variation in populations of persistently colonizing Helicobacter pylori." The Journal of Infectious Diseases, 188(), 486-496, 2003.
El-Omar E and Peek RM "Rapid Reference to Dyspepsia." Harcourt Publishers, London, U.K., 2003.
Peek, RM Suppression of pathogenesis: bacteria lead the way. Gastroenterology, 124(5), 1550-2; discussion 1552, 2003.
Peek RM. "The politics of H. pylori-challenged mice: liberal permissiveness versus conservative restriction.." Gastroenterology, 124577-578, 2003.
Peek, RM The role of PPARgamma in colon cancer: is it as simple as APC. Gastroenterology, 125(2), 619-21, 2003.
Peek RM. "The superiority of proton pump inhibitor-based regimens for Helicobacter pylori eradication. Evidence-Based." Gastroenterology, 446-47, 2003.
Ando, T, Wassenaar, TM, Peek, RM, Aras, RA, Tschumi, AI, van Doorn, LJ, Kusugami, K, Blaser, MJ A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains. Cancer Res, 62(8), 2385-9, 2002.
Takeuchi, Hiroaki, Israel, Dawn A, Miller, Geraldine G, Donahue, John P, Krishna, Uma, Gaus, Kristin, Peek, Richard M Characterization of expression of a functionally conserved Helicobacter pylori methyltransferase-encoding gene within inflamed mucosa and during in vitro growth. J Infect Dis, 186(8), 1186-9, 2002.
Peek, RM Elimination of Helicobacter pylori or acid in high-risk users of aspirin or nonsteroidal medications: final answer. Gastroenterology, 122(1), 238-40, 2002.
Graham, James E, Peek, Richard M, Krishna, Uma, Cover, Timothy L Global analysis of Helicobacter pylori gene expression in human gastric mucosa. Gastroenterology, 123(5), 1637-48, 2002.
Peek, Richard M, Blaser, Martin J Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer, 2(1), 28-37, 2002.
Goldblum, JR, Richter, JE, Vaezi, M, Falk, GW, Rice, TW, Peek, RM Helicobacter pylori infection, not gastroesophageal reflux, is the major cause of inflammation and intestinal metaplasia of gastric cardiac mucosa. Am J Gastroenterol, 97(2), 302-11, 2002.
Peek, Richard M Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis. J Gastroenterol, 37 Suppl 1310-6, 2002.
Grady, WM, Peek, RM Hereditary diffuse gastric cancer: more answers or more questions. Gastroenterology, 122(3), 830-1; discussion 831-2, 2002.
Ando, T, Peek, RM, Lee, YC, Krishna, U, Kusugami, K, Blaser, MJ Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan. Clin Diagn Lab Immunol, 9(1), 167-75, 2002.
Ando T, Peek RM, Lee Y-C, Krishna U, Kusugami K, and Blaser MJ. "Host cell responses to genotypically similar Helicobacter pylori isolates from the United States and Japan.." Clin. Diag. Lab. Immunol., 9167-175, 2002.
Nozawa, Y, Nishihara, K, Peek, RM, Nakano, M, Uji, T, Ajioka, H, Matsuura, N, Miyake, H Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. Biochem Pharmacol, 64(1), 21-30, 2002.
Peek RM. "Is CagA ready for prime time? Evidence-Based." Gastroenterology, 378-79, 2002.
Peek, RM New insights into microbially initiated gastric malignancies: beyond the usual suspects. Gastroenterology, 123(5), 1739-40; discussion 1740-1, 2002.
Peek RM. "New insights into microbially-initiated gastric malignancies: beyond the usual suspects.." Gastroenterology, 1231739-1740, 2002.
Peek, RM Persistence and pathogenesis: a great defense facilitates a good offense. Gastroenterology, 122(7), 2084-5, 2002.
Ando T, Peek RM, Pride D, Levine S, Takata T, Kusugami K, van der Ende A, Kuipers EJ, Kusters JG, and Blaser MJ. "Polymorphisms of Helicobacter pylori HP0638 reflect strain geographic origin and correlate with cagA status.." J. Clin. Microbiol., , 40239-246, 2002.
Gupta, R A, Polk, D B, Krishna, U, Israel, D A, Yan, F, DuBois, R N, Peek, R M Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem, 276(33), 31059-66, 2001.
Kidd M, Peek RM, Lastovica AJ, Israel DA, Kummer AF, and Louw JA. "Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease.." Gut, 49629-635, 2001.
Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM, Shaw LM, and Kelly CP. "Cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells.." J. Biol. Chem., 27648127-48134, 2001.
Iwase H, Maeda O, Shimada M, Tsuzuki T, Peek RM, Nishio Y, Ando T, Ina K, and Kusugami K. "Endoscopic ablation with cyanoacrylate glue for isolated gastric variceal bleeding.." Gastrointestinal Endoscopy, 53585-592, 2001.
Israel, D A, Salama, N, Krishna, U, Rieger, U M, Atherton, J C, Falkow, S, Peek, R M Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci U S A, 98(25), 14625-30, 2001.
Tham, K T, Peek, R M, Atherton, J C, Cover, T L, Perez-Perez, G I, Shyr, Y, Blaser, M J Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease. Hum Pathol, 32(3), 264-73, 2001.
Israel, D A, Salama, N, Arnold, C N, Moss, S F, Ando, T, Wirth, H P, Tham, K T, Camorlinga, M, Blaser, M J, Falkow, S, Peek, R M Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J Clin Invest, 107(5), 611-20, 2001.
Peek RM. "Helicobacter pylori, aspirin, and nonsteroidal medications, and complications of ulcer disease: seeing through the glass less dimly? Evidence-Based." Gastroenterology, 258-60, 2001.
Peek, R M IV. Helicobacter pylori strain-specific activation of signal transduction cascades related to gastric inflammation. Am J Physiol Gastrointest Liver Physiol, 280(4), G525-30, 2001.
Peek RM. "Molecular dissection of the mechanisms through which Enteropathogenic Escherichia coli induce diarrhea.." Gastroenterology, 121496-497, 2001.
Donahue JP, and Peek RM. "Restriction and modification systems.." In: Hazell S, Mendz G, Mobley H, editors. Helicobacter pylori. ASM press, Washington D.C., , 269-276, 2001.
Peek, R M The biological impact of Helicobacter pylori colonization. Semin Gastrointest Dis, 12(3), 151-66, 2001.
Israel, D A, Peek, R M pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment Pharmacol Ther, 15(9), 1271-90, 2001.
Donahue, J P, Peek, R M, Van Doorn, L J, Thompson, S A, Xu, Q, Blaser, M J, Miller, G G Analysis of iceA1 transcription in Helicobacter pylori. Helicobacter, 5(1), 1-12, 2000.
Vaezi MF, Falk GW, Peek RM, Vicari JJ, Goldblum JR, Perez-Perez GI, Rice TW, Blaser MJ, and Richter JE. "CagA positive strains of Helicobacter pylori may protect against Barrett's esophagus.." Am. J. Gastro., , 952206-2211, 2000.
Iwase H, Kusugami K, Suzuki M, Nishio Y, Ando T, Ina K, and Peek RM. "Endoscopic resection of early-stage esophageal cancer accompanied by esophageal varices.." Gastrointestinal Endoscopy, 51749-752, 2000.
Figueiredo C, Quint WGV, Sanna R, Sablon E, Donahue JP, Xu Q, Miller GG, Peek RM, Blaser MJ, and van Doorn LJ "Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori.." Gene, 2459-68, 2000.
Peek, R M, Wirth, H P, Moss, S F, Yang, M, Abdalla, A M, Tham, K T, Zhang, T, Tang, L H, Modlin, I M, Blaser, M J Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology, 118(1), 48-59, 2000.
Donahue, J P, Israel, D A, Peek, R M, Blaser, M J, Miller, G G Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori. Mol Microbiol, 37(5), 1066-74, 2000.
Peek, R M, van Doorn, L J, Donahue, J P, Tham, K T, Figueiredo, C, Blaser, M J, Miller, G G Quantitative detection of Helicobacter pylori gene expression in vivo and relationship to gastric pathology. Infect Immun, 68(10), 5488-95, 2000.
Hayakawa M, Shimokawa K, Kusugami K, Sugihara M, Morooka Y, Fujita T, Nakamura M, Nishio Y, Maeda K, Ando T, and Peek RM. "Clinicopathological features of superficial depressed-type colorectal neoplastic lesions.." Am. J. Gastro, 94944-949, 1999.
Perez-Perez, G I, Peek, R M, Atherton, J C, Blaser, M J, Cover, T L Detection of anti-VacA antibody responses in serum and gastric juice samples using type s1/m1 and s2/m2 Helicobacter pylori VacA antigens. Clin Diagn Lab Immunol, 6(4), 489-93, 1999.
Keates S, Keates AC, Warny M, Peek RM, Murray PG, and Kelly CP. "Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori.." J. Immunol., 1635552-55529, 1999.
Peek, R M, Blaser, M J, Mays, D J, Forsyth, M H, Cover, T L, Song, S Y, Krishna, U, Pietenpol, J A Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res, 59(24), 6124-31, 1999.
Wirth, H P, Yang, M, Peek, R M, HÃ¶Ã¶k-Nikanne, J, Fried, M, Blaser, M J Phenotypic diversity in Lewis expression of Helicobacter pylori isolates from the same host. J Lab Clin Med, 133(5), 488-500, 1999.
Peek, R M, Vaezi, M F, Falk, G W, Goldblum, J R, Perez-Perez, G I, Richter, J E, Blaser, M J Role of Helicobacter pylori cagA(+) strains and specific host immune responses on the development of premalignant and malignant lesions in the gastric cardia. Int J Cancer, 82(4), 520-4, 1999.
Perez-Perez, G I, Peek, R M, Legath, A J, Heine, P R, Graff, L B The role of CagA status in gastric and extragastric complications of Helicobacter pylori. J Physiol Pharmacol, 50(5), 833-45, 1999.
Atherton JC, Sharp PM, Cover TL, Gonzales-Valencia G, Peek RM, Thompson SA, Hawkey CJ, and Blaser MJ. "Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, ml and m2, and have evolved through limited recombination.." Current Microbiol., 39211-218, 1999.
Peek, R M, Thompson, S A, Donahue, J P, Tham, K T, Atherton, J C, Blaser, M J, Miller, G G Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc Assoc Am Physicians, 110(6), 531-44, 1998.
HÃ¶Ã¶k-Nikanne, J, Berg, D E, Peek, R M, Kersulyte, D, Tummuru, M K, Blaser, M J DNA sequence conservation and diversity in transposable element IS605 of Helicobacter pylori. Helicobacter, 3(2), 79-85, 1998.
Goldblum JR, Vicari JJ, Falk GW, Rice TW, Peek RM, Easley K, and Richter JE. "Inflammation and intestinal metaplasia of the gastric cardia: the role of gastroesophageal reflux and H. pylori infection.." Gastroenterology, 114633-639, 1998.
Vicari JJ, Peek RM, Falk GW, Goldblum JR, Easley KA, Schnell J, Perez-Perez GI, Halter SA, Rice TW, Blaser MJ, and Richter JE. "The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease.." Gastroenterology, 11550-57, 1998.
Atherton JC, Peek RM, Tham KT, Cover TL, and Blaser MJ. "Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.." Gastroenterology, 11292-99, 1997.
Wirth, H P, Yang, M, Peek, R M, Tham, K T, Blaser, M J Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Gastroenterology, 113(4), 1091-8, 1997.
Peek, R M, Moss, S F, Tham, K T, Perez-Perez, G I, Wang, S, Miller, G G, Atherton, J C, Holt, P R, Blaser, M J Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer Inst, 89(12), 863-8, 1997.
Peek RM, and Blaser MJ. "Helicobacter pylori, peptic ulcer disease and gastric cancer.." Mechanisms of Microbial Disease. Williams and Wilkins,, 1997.
Peek RM, and Blaser MJ. "Pathophysiology of Helicobacter pylori-induced gastritis and peptic ulcer disease.." Am. J. Med., 102200-207, 1997.
Sharma SA, Miller GG, Peek RM, Perez-Perez GI, and Blaser MJ. "T-cell, antibody, and cytokine responses to homologs of the 60-kilodalton heat shock protein in Helicobacter pylori infection.." Clin. Diag. Lab. Immunol., 4440-446, 1997.
Xu, Q, Peek, R M, Miller, G G, Blaser, M J The Helicobacter pylori genome is modified at CATG by the product of hpyIM. J Bacteriol, 179(21), 6807-15, 1997.
Atherton, J C, Tham, K T, Peek, R M, Cover, T L, Blaser, M J Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis, 174(3), 552-6, 1996.
Peek, R M, Miller, G G, Tham, K T, Perez-Perez, G I, Cover, T L, Atherton, J C, Dunn, G D, Blaser, M J Detection of Helicobacter pylori gene expression in human gastric mucosa. J Clin Microbiol, 33(1), 28-32, 1995.
Peek, R M, Miller, G G, Tham, K T, Perez-Perez, G I, Zhao, X, Atherton, J C, Blaser, M J Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest, 73(6), 760-70, 1995.
Blaser, M J, Perez-Perez, G I, Kleanthous, H, Cover, T L, Peek, R M, Chyou, P H, Stemmermann, G N, Nomura, A Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res, 55(10), 2111-5, 1995.
Atherton, J C, Cao, P, Peek, R M, Tummuru, M K, Blaser, M J, Cover, T L Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem, 270(30), 17771-7, 1995.
Peek RM, Miller GG, and Blaser MJ. "Reverse transcription-Polymerase chain reaction (RT-PCR) for bacterial and host gene expression in human gastric mucosa. In: Lee, A., Megraud, F., editors. Helicobacter pylori: Techniques for Clinical Diagnosis and Basic Research.." W.B. Saunders Ltd., 163-173, 1995.
Peek RM, and Truss C. "Diarrhea following a dog bite." Dig. Dis. Sci., 361151-1153, 1991.

Education

M.D. - University of North Carolina at Chapel Hill, 1988
Fellowship - Vanderbilt University Medical Center, 1995
Residency - University of Alabama at Birmingham Health System, 1992
Internship - University of Alabama at Birmingham Health System, 1989

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Vanderbilt-Ingram Cancer Center

Types of Cancer

See Also