Vanderbilt-Ingram Cancer Center

The VICC.ORG Investigator Directory

Timothy Scott Blackwell, M.D.

See also:

• Thoracic/Head and Neck Cancer Research Program
• Cancer Biology
• Medicine: Allergy, Pulmonary, and Critical Care
• BRET: Biomedical Research Education & Training Faculty Listing

Learn More About Timothy Scott Blackwell's Specialties:

• Lung Cancer - Non Small Cell
• Lung Cancer - Small Cell
• Malignant Mesothelioma
• Thymoma and Thymic Carcinoma

Rudolph H. Kampmeier Professor of Medicine, Cancer Biology, and Cell and Developmental Biology
Director, Division of Allergy, Pulmonary, and Critical Care Medicine and the Center for Lung Research
VICC Member
Pulmonologist

Contact Information:

Vanderbilt University Medical Center
1161 21st Ave. S. Suite T-1218 MCN
Nashville, TN 37232-2650
615-343-4761
Fax: 615-322-2582

Research Description:

My laboratory investigates lung inflamamtion/injury, remodeling, fibrosis, and development of lung cancer. Lung inflammation is important for host defense functions but can contribute to tissue injury when the inflammation is excessive or dysregulated. By studying the NF-kB transcription pathway, we hope to better understand factors that control lung inflammation, injury, and host defense. We are also interested in the basic mechanisms that lead to normal lung repair or fibrosis following injury and mechanisms by which chronic inflammation alters the lung microenvironment in a pro-tumorigenic manner.

Clinical Interest:

acute lung injury/ARDS
idiopathic pulmonary fibrosis
lung cancer

Publications:

• Kropski, JA, Lawson, WE, Young, LR, Blackwell, TS Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis. Dis Model Mech, 6(1), 9-17, 2013.
• Tanjore, H, Degryse, AL, Crossno, PF, Xu, XC, McConaha, ME, Jones, BR, Polosukhin, VV, Bryant, AJ, Cheng, DS, Newcomb, DC, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE ¿¿-Catenin in the Alveolar Epithelium Protects from Lung Fibrosis following Intratracheal Bleomycin. Am J Respir Crit Care Med, 2013.
• Han, W, Li, H, Segal, BH, Blackwell, TS Bioluminescence imaging of NADPH oxidase activity in different animal models. J Vis Exp, (68), 2012.
• Tanjore, H, Blackwell, TS, Lawson, WE Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 302(8), L721-9, 2012.
• Tanjore, H, Lawson, WE, Blackwell, TS Endoplasmic reticulum stress as a pro-fibrotic stimulus. Biochim Biophys Acta, 2012.
• Zaynagetdinov, R, Stathopoulos, GT, Sherrill, TP, Cheng, DS, McLoed, AG, Ausborn, JA, Polosukhin, VV, Connelly, L, Zhou, W, Fingleton, B, Peebles, RS, Prince, LS, Yull, FE, Blackwell, TS Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene, 31(26), 3164-76, 2012.
• Barham, W, Sherrill, T, Connelly, L, Blackwell, TS, Yull, FE Intraductal injection of LPS as a mouse model of mastitis: signaling visualized via an NF-¿¿B reporter transgenic. J Vis Exp, (67), e4030, 2012.
• Polosukhin, VV, Degryse, AL, Newcomb, DC, Jones, BR, Ware, LB, Lee, JW, Loyd, JE, Blackwell, TS, Lawson, WE Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res, 38(3), 135-46, 2012.
• Kropski, JA, Lawson, WE, Blackwell, TS Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 302(5), L441-4, 2012.
• Degryse, AL, Xu, XC, Newman, JL, Mitchell, DB, Tanjore, H, Polosukhin, VV, Jones, BR, McMahon, FB, Gleaves, LA, Phillips, JA, Cogan, JD, Blackwell, TS, Lawson, WE Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Exp Lung Res, 38(3), 124-34, 2012.
• Young, LR, Gulleman, PM, Bridges, JP, Weaver, TE, Deutsch, GH, Blackwell, TS, McCormack, FX The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am J Respir Crit Care Med, 186(10), 1014-24, 2012.
• Zaynagetdinov, R, Sherrill, TP, Polosukhin, VV, Han, W, Ausborn, JA, McLoed, AG, McMahon, FB, Gleaves, LA, Degryse, AL, Stathopoulos, GT, Yull, FE, Blackwell, TS A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J Immunol, 187(11), 5703-11, 2011.
• Tanjore, H, Cheng, DS, Degryse, AL, Zoz, DF, Abdolrasulnia, R, Lawson, WE, Blackwell, TS Alveolar epithelial cells undergo epithelial to mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem, 2011.
• Polosukhin, VV, Cates, JM, Lawson, WE, Zaynagetdinov, R, Milstone, AP, Massion, PP, Ocak, S, Lee, JW, Bowler, RP, Kononov, AV, Randell, SH, Blackwell, TS Bronchial Secretory IgA Deficiency Correlates With Airway Inflammation and Progression of COPD. Am J Respir Crit Care Med, 2011.
• Phillips, JA, Cogan, JD, Austin, ED, Larkin, EK, Markin, CR, Lawson, WE, Newman, JH, Loyd, JE, Blackwell, TS Differences in Average Age of Onset, Locus Heterogeneity, and Penetrance between Familial Pulmonary Arterial Hypertension and Familial Interstitial Pneumonia Can Predict the Success of Linkage and Whole Exome Sequencing in Discovering Disease-Causing Alleles. Proc Am Thorac Soc, 8(2), 205-6, 2011.
• Lawson, WE, Cheng, DS, Degryse, AL, Tanjore, H, Polosukhin, VV, Xu, XC, Newcomb, DC, Jones, BR, Roldan, J, Lane, KB, Morrisey, EE, Beers, MF, Yull, FE, Blackwell, TS Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A, 2011.
• Polosukhin, VV, Cates, JM, Lawson, WE, Milstone, AP, Matafonov, AG, Massion, PP, Lee, JW, Randell, SH, Blackwell, TS Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J Pathol, 224(2), 203-11, 2011.
• Zoz, DF, Lawson, WE, Blackwell, TS Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction. Am J Med Sci, 341(6), 435-8, 2011.
• Connelly, L, Barham, W, Onishko, HM, Sherrill, T, Chodosh, LA, Blackwell, TS, Yull, FE Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene, 30(12), 1402-12, 2011.
• Lawson, WE, Blackwell, TS, Gauldie, J Let It Be: microRNAs Impact Interstitial Lung Disease. Am J Respir Crit Care Med, 183(1), 1-2, 2011.
• Connelly, L, Barham, W, Onishko, HM, Chen, L, Sherrill, TP, Zabuawala, T, Ostrowski, MC, Blackwell, TS, Yull, FE NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Res, 13(4), R83, 2011.
• Blackwell, TS, Hipps, AN, Yamamoto, Y, Han, W, Barham, WJ, Ostrowski, MC, Yull, FE, Prince, LS NF-{kappa}B Signaling in Fetal Lung Macrophages Disrupts Airway Morphogenesis. J Immunol, 187(5), 2740-7, 2011.
• Zhou, W, Dowell, DR, Geraci, MW, Blackwell, TS, Collins, RD, Polosukhin, VV, Lawson, WE, Wu, P, Sussan, T, Biswal, S, Goleniewska, K, O''Neal, J, Newcomb, DC, Toki, S, Morrow, JD, Peebles, RS PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am J Physiol Lung Cell Mol Physiol, 301(4), L615-22, 2011.
• Grimm, MJ, Vethanayagam, RR, Almyroudis, NG, Lewandowski, D, Rall, N, Blackwell, TS, Segal, BH Role of NADPH oxidase in host defense against aspergillosis. Med Mycol, 49 Suppl 1S144-9, 2011.
• Degryse, AL, Tanjore, H, Xu, XC, Polosukhin, VV, Jones, BR, Boomershine, CS, Ortiz, C, Sherrill, TP, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE TGF{beta} signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am J Physiol Lung Cell Mol Physiol, 300(6), L887-97, 2011.
• Dworski, R, Han, W, Blackwell, TS, Hoskins, A, Freeman, ML Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic Biol Med, 2011.
• Connelly, L, Barham, W, Pigg, R, Saint-Jean, L, Sherrill, T, Cheng, DS, Chodosh, LA, Blackwell, TS, Yull, FE Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. J Cell Physiol, 222(1), 73-81, 2010.
• Doris, K, Karabela, SP, Kairi, CA, Simoes, DC, Roussos, C, Zakynthinos, SG, Kalomenidis, I, Blackwell, TS, Stathopoulos, GT Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice. Respir Res, 11118, 2010.
• Williams, B.J., Du, R.-H., Calcull, W., Abdolrasulnia, R., Christman, B.W., Blackwell, T.S. "Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa.." Mol. Microbiol, 2010.
• Role of NADPH oxidase in host defense against Aspergillus. "Grimm, M.J., Vethanayagam, R.R., Almyroudis, N.G., Lewandowski, D., Rall, N., Blackwell, T.S., Segal, B.H.." Medical Mycology, 2010.
• Stathopoulos, GT, Sherrill, TP, Karabela, SP, Goleniewska, K, Kalomenidis, I, Roussos, C, Fingleton, B, Yull, FE, Peebles, RS, Blackwell, TS Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am J Respir Crit Care Med, 182(10), 1273-81, 2010.
• Stathopoulos, G.T., Sherrill, T.P., Karabela, S.P., Goleniewska, K., Kalomenidis, I., Roussos, C., Fingleton, B., Yull, F.E., Peebles, R.S., Blackwell, T.S. "Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.." Am. J. Respir. Crit. Care Med., 2010.
• Crossno, PF, Polosukhin, VV, Blackwell, TS, Johnson, JE, Markin, C, Moore, PE, Worrell, JA, Stahlman, MT, Phillips, JA, Loyd, JE, Cogan, JD, Lawson, WE Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest, 137(4), 969-73, 2010.
• Kobayashi, H, Huang, J, Ye, F, Shyr, Y, Blackwell, TS, Lin, PC Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model. PLoS One, 5(3), e9458, 2010.
• Segal, B.H., Han, W., Bushey, J.J., Joo, M., Bhatti, Z., Feminella, J., Dennis, C.G., Vethanayagam, R.R., Yull, F.E., Capitano, M., Wallace, P.K., Minderman, H., Christman, J.W., Sporn, M.B., Chan, J., Vinh, D.C., Holland, S.M., Romani, L.R., Gaffen, S.L., Freeman, M.L., Blackwell, T.S. "NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice.." PLoS One , 5(3)e9631, 2010.
• Segal, BH, Han, W, Bushey, JJ, Joo, M, Bhatti, Z, Feminella, J, Dennis, CG, Vethanayagam, RR, Yull, FE, Capitano, M, Wallace, PK, Minderman, H, Christman, JW, Sporn, MB, Chan, J, Vinh, DC, Holland, SM, Romani, LR, Gaffen, SL, Freeman, ML, Blackwell, TS NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One, 5(3), e9631, 2010.
• Benjamin, JT, Carver, BJ, Plosa, EJ, Yamamoto, Y, Miller, JD, Liu, JH, van der Meer, R, Blackwell, TS, Prince, LS NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol, 185(8), 4896-903, 2010.
• Lee, HJ, Joo, M, Abdolrasulnia, R, Young, DG, Choi, I, Ware, LB, Blackwell, TS, Christman, BW Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Biol Chem, 285(51), 39655-62, 2010.
• Williams, BJ, Dehnbostel, J, Blackwell, TS Pseudomonas aeruginosa: host defence in lung diseases. Respirology, 15(7), 1037-56, 2010.
• Degryse, AL, Tanjore, H, Xu, XC, Polosukhin, VV, Jones, BR, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 299(4), L442-52, 2010.
• Psallidas, I, Karabela, SP, Moschos, C, Sherrill, TP, Kollintza, A, Magkouta, S, Theodoropoulou, P, Roussos, C, Blackwell, TS, Kalomenidis, I, Stathopoulos, GT Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study. Mol Cancer, 956, 2010.
• Psallidas, I., Karabela, S.P., Moschos, C., Sherrill, T.P., Kollintza, A., Magkouta, S., Theodoropoulou, P., Roussos, C., Blackwell, T.S., Kalomenidis, I., Stathopoulos, G.T. "Speficic effects of bortezomib against experimental malignant pleural effusion: a preclinical study.." Mol. Cancer, 956, 2010.
• Boomershine, CS, Chamberlain, A, Kendall, P, Afshar-Sharif, AR, Huang, H, Washington, MK, Lawson, WE, Thomas, JW, Blackwell, TS, Bhowmick, NA Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut, 58(9), 1267-74, 2009.
• Tanjore, H, Xu, XC, Polosukhin, VV, Degryse, AL, Li, B, Han, W, Sherrill, TP, Plieth, D, Neilson, EG, Blackwell, TS, Lawson, WE Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med, 180(7), 657-65, 2009.
• Ma, LL, Gao, X, Liu, L, Xiang, Z, Blackwell, TS, Williams, P, Chari, RS, Yin, DP CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance. Liver Transpl, 15(8), 915-23, 2009.
• Bastarache, JA, Blackwell, TS Development of animal models for the acute respiratory distress syndrome. Dis Model Mech, 2(5-6), 218-23, 2009.
• Han, W, Joo, M, Everhart, MB, Christman, JW, Yull, FE, Blackwell, TS Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol, 296(3), L320-7, 2009.
• Sheller, JR, Polosukhin, VV, Mitchell, D, Cheng, DS, Peebles, RS, Blackwell, TS Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res, 35(10), 883-95, 2009.
• Sadagopal, S, Braunstein, M, Hager, CC, Wei, J, Daniel, AK, Bochan, MR, Crozier, I, Smith, NE, Gates, HO, Barnett, L, Van Kaer, L, Price, JO, Blackwell, TS, Kalams, SA, Kernodle, DS Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS One, 4(5), e5531, 2009.
• Ma, L, Xiang, Z, Sherrill, TP, Wang, L, Blackwell, TS, Williams, P, Chong, A, Chari, R, Yin, DP Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation. Transplantation, 85(6), 903-10, 2008.
• Lewis, CC, Yang, JY, Huang, X, Banerjee, SK, Blackburn, MR, Baluk, P, McDonald, DM, Blackwell, TS, Nagabhushanam, V, Peters, W, Voehringer, D, Erle, DJ Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med, 177(4), 376-87, 2008.
• Musiek, ES, Brooks, JD, Joo, M, Brunoldi, E, Porta, A, Zanoni, G, Vidari, G, Blackwell, TS, Montine, TJ, Milne, GL, McLaughlin, B, Morrow, JD Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J Biol Chem, 2008.
• Lawson, WE, Crossno, PF, Polosukhin, VV, Roldan, J, Cheng, DS, Lane, KB, Blackwell, TR, Xu, C, Markin, C, Ware, LB, Miller, GG, Loyd, JE, Blackwell, TS Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol, 294(6), L1119-26, 2008.
• Joo, M, Kwon, M, Azim, AC, Sadikot, RT, Blackwell, TS, Christman, JW Genetic determination of the role of PU.1 in macrophage gene expression. Biochem Biophys Res Commun, 372(1), 97-102, 2008.
• Stathopoulos, GT, Sherrill, TP, Han, W, Sadikot, RT, Yull, FE, Blackwell, TS, Fingleton, B Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol Cancer Res, 6(3), 364-71, 2008.
• Tager, AM, Lacamera, P, Shea, BS, Campanella, GS, Selman, M, Zhao, Z, Polosukhin, V, Wain, J, Karimi-Shah, BA, Kim, ND, Hart, WK, Poorvu, EC, Brooks, SF, Bercury, SD, Pardo, A, Blackwell, TS, Xu, Y, Chun, J, Luster, AD The Lysophosphatidic Acid Receptor LPA1 Links Pulmonary Fibrosis to Lung Injury by Mediating Fibroblast Recruitment and Vascular Leak. Proc Am Thorac Soc, 5(3), 363, 2008.
• Tager, AM, LaCamera, P, Shea, BS, Campanella, GS, Selman, M, Zhao, Z, Polosukhin, V, Wain, J, Karimi-Shah, BA, Kim, ND, Hart, WK, Pardo, A, Blackwell, TS, Xu, Y, Chun, J, Luster, AD The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med, 14(1), 45-54, 2008.
• Chen, SM, Cheng, DS, Williams, BJ, Sherrill, TP, Han, W, Chont, M, Saint-Jean, L, Christman, JW, Sadikot, RT, Yull, FE, Blackwell, TS The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin Exp Immunol, 153(3), 420-8, 2008.
• Jin, RJ, Lho, Y, Connelly, L, Wang, Y, Yu, X, Saint Jean, L, Case, TC, Ellwood-Yen, K, Sawyers, CL, Bhowmick, NA, Blackwell, TS, Yull, FE, Matusik, RJ The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res, 68(16), 6762-9, 2008.
• Connelly, L, Robinson-Benion, C, Chont, M, Saint-Jean, L, Li, H, Polosukhin, VV, Blackwell, TS, Yull, FE A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. J Biol Chem, 282(13), 10028-35, 2007.
• Cheng, DS, Han, W, Chen, SM, Sherrill, TP, Chont, M, Park, GY, Sheller, JR, Polosukhin, VV, Christman, JW, Yull, FE, Blackwell, TS Airway epithelium controls lung inflammation and injury through the NF-kappaB pathway. J Immunol, 178(10), 6504-13, 2007.
• Polosukhin, VV, Lawson, WE, Milstone, AP, Egunova, SM, Kulipanov, AG, Tchuvakin, SG, Massion, PP, Blackwell, TS Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch, 451(4), 793-803, 2007.
• Sadikot, RT, Zeng, H, Azim, AC, Joo, M, Dey, SK, Breyer, RM, Peebles, RS, Blackwell, TS, Christman, JW Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur J Immunol, 37(4), 1001-9, 2007.
• Park, GY, Hu, N, Wang, X, Sadikot, RT, Yull, FE, Joo, M, Stokes Peebles, R, Blackwell, TS, Christman, JW Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. Clin Exp Immunol, 150(2), 245-54, 2007.
• Stathopoulos, GT, Sherrill, TP, Cheng, DS, Scoggins, RM, Han, W, Polosukhin, VV, Connelly, L, Yull, FE, Fingleton, B, Blackwell, TS Epithelial NF-{kappa}B activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A, 104(47), 18514-9, 2007.
• Joo, M, Kwon, M, Sadikot, RT, Kingsley, PJ, Marnett, LJ, Blackwell, TS, Peebles, RS, Urade, Y, Christman, JW Induction and function of lipocalin prostaglandin D synthase in host immunity. J Immunol, 179(4), 2565-75, 2007.
• Zhang, H, Lawson, WE, Polosukhin, VV, Pozzi, A, Blackwell, TS, Litingtung, Y, Chiang, C Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol, 171(4), 1113-26, 2007.
• Glasgow, SC, Ramachandran, S, Blackwell, TS, Mohanakumar, T, Chapman, WC Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice. Am J Physiol Lung Cell Mol Physiol, 293(2), L491-6, 2007.
• Zhou, W, Blackwell, TS, Goleniewska, K, O'Neal, JF, Fitzgerald, GA, Lucitt, M, Breyer, RM, Peebles, RS Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol, 81(3), 809-17, 2007.
• Zhou, W, Hashimoto, K, Goleniewska, K, O'Neal, JF, Ji, S, Blackwell, TS, Fitzgerald, GA, Egan, KM, Geraci, MW, Peebles, RS Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol, 178(2), 702-10, 2007.
• Stathopoulos, GT, Kollintza, A, Moschos, C, Psallidas, I, Sherrill, TP, Pitsinos, EN, Vassiliou, S, Karatza, M, Papiris, SA, Graf, D, Orphanidou, D, Light, RW, Roussos, C, Blackwell, TS, Kalomenidis, I Tumor necrosis factor-alpha promotes malignant pleural effusion. Cancer Res, 67(20), 9825-34, 2007.
• Stathopoulos, GT, Sherrill, TP, Han, W, Sadikot, RT, Polosukhin, VV, Fingleton, B, Yull, FE, Blackwell, TS Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin Exp Metastasis, 2007.
• Kalomenidis, I, Stathopoulos, GT, Barnette, R, Papiris, S, Blackwell, TS, Roussos, C, Light, RW Vascular endothelial growth factor levels in post-CABG pleural effusions are associated with pleural inflammation and permeability. Respir Med, 101(2), 223-9, 2007.
• Joo, M, Wright, JG, Hu, NN, Sadikot, RT, Park, GY, Blackwell, TS, Christman, JW Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. Am J Physiol Lung Cell Mol Physiol, 292(5), L1219-26, 2007.
• Gray, KD, Simovic, MO, Blackwell, TS, Christman, JW, May, AK, Parman, KS, Chapman, WC, Stain, SC Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis. Pancreas, 33(3), 260-7, 2006.
• Chen, JX, Zeng, H, Lawrence, ML, Blackwell, TS, Meyrick, B Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. Am J Physiol Heart Circ Physiol, 291(4), H1563-72, 2006.
• Everhart, MB, Han, W, Sherrill, TP, Arutiunov, M, Polosukhin, VV, Burke, JR, Sadikot, RT, Christman, JW, Yull, FE, Blackwell, TS Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol, 176(8), 4995-5005, 2006.
• Dieperink, HI, Blackwell, TS, Prince, LS Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatr Res, 59(2), 185-90, 2006.
• Park, GY, Wang, X, Hu, N, Pedchenko, TV, Blackwell, TS, Christman, JW NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha. J Biol Chem, 281(27), 18684-90, 2006.
• Stathopoulos, GT, Zhu, Z, Everhart, MB, Kalomenidis, I, Lawson, WE, Bilaceroglu, S, Peterson, TE, Mitchell, D, Yull, FE, Light, RW, Blackwell, TS Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. Am J Respir Cell Mol Biol, 34(2), 142-50, 2006.
• Stafforini, DM, Sheller, JR, Blackwell, TS, Sapirstein, A, Yull, FE, McIntyre, TM, Bonventre, JV, Prescott, SM, Roberts, LJ Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem, 281(8), 4616-23, 2006.
• Maus, UA, Janzen, S, Wall, G, Srivastava, M, Blackwell, TS, Christman, JW, Seeger, W, Welte, T, Lohmeyer, J Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol, 35(2), 227-35, 2006.
• Sadikot, RT, Zeng, H, Joo, M, Everhart, MB, Sherrill, TP, Li, B, Cheng, DS, Yull, FE, Christman, JW, Blackwell, TS Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol, 176(8), 4923-30, 2006.
• Sadikot, RT, Blackwell, TS Bioluminescence imaging. Proc Am Thorac Soc, 2(6), 537-40, 511-2, 2005.
• Maus, UA, Wellmann, S, Hampl, C, Kuziel, WA, Srivastava, M, Mack, M, Everhart, MB, Blackwell, TS, Christman, JW, Schlöndorff, D, Bohle, RM, Seeger, W, Lohmeyer, J CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am J Physiol Lung Cell Mol Physiol, 288(2), L350-8, 2005.
• Lawson, WE, Polosukhin, VV, Zoia, O, Stathopoulos, GT, Han, W, Plieth, D, Loyd, JE, Neilson, EG, Blackwell, TS Characterization of Fibroblast-specific Protein 1 in Pulmonary Fibrosis. Am J Respir Crit Care Med, 171(8), 899-907, 2005.
• Musiek, ES, Gao, L, Milne, GL, Han, W, Everhart, MB, Wang, D, Backlund, MG, DuBois, RN, Zanoni, G, Vidari, G, Blackwell, TS, Morrow, JD Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J Biol Chem, 280(42), 35562-70, 2005.
• Kalomenidis, I, Stathopoulos, GT, Barnette, R, Guo, Y, Peebles, RS, Blackwell, TS, Light, RW Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions. Chest, 127(6), 2094-100, 2005.
• Joo, M, Hahn, YS, Kwon, M, Sadikot, RT, Blackwell, TS, Christman, JW Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. J Virol, 79(12), 7648-57, 2005.
• Lawson, WE, Polosukhin, VV, Stathopoulos, GT, Zoia, O, Han, W, Lane, KB, Li, B, Donnelly, EF, Holburn, GE, Lewis, KG, Collins, RD, Hull, WM, Glasser, SW, Whitsett, JA, Blackwell, TS Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am J Pathol, 167(5), 1267-77, 2005.
• Pedchenko, TV, Park, GY, Joo, M, Blackwell, TS, Christman, JW Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia. Am J Physiol Lung Cell Mol Physiol, 289(3), L429-37, 2005.
• Everhart, MB, Han, W, Parman, KS, Polosukhin, VV, Zeng, H, Sadikot, RT, Li, B, Yull, FE, Christman, JW, Blackwell, TS Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. J Leukoc Biol, 77(2), 173-80, 2005.
• O'Donnell, SM, Hansberger, MW, Connolly, JL, Chappell, JD, Watson, MJ, Pierce, JM, Wetzel, JD, Han, W, Barton, ES, Forrest, JC, Valyi-Nagy, T, Yull, FE, Blackwell, TS, Rottman, JN, Sherry, B, Dermody, TS Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest, 115(9), 2341-50, 2005.
• Sadikot, RT, Blackwell, TS, Christman, JW, Prince, AS Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med, 171(11), 1209-23, 2005.
• Cheng, Q, Zhao, Y, Lawson, WE, Polosukhin, VV, Johnson, JE, Blackwell, TS, Gailani, D The effects of intrinsic pathway protease deficiencies on plasminogen deficient mice. Blood, 2005.
• Polosukhin, VV, Stathopoulos, GT, Lawson, WE, Blackwell, TS Variability of interalveolar septal remodeling after bleomycin treatment in mice. Ultrastruct Pathol, 29(1), 53-64, 2005.
• Lawson, WE, Grant, SW, Ambrosini, V, Womble, KE, Dawson, EP, Lane, KB, Markin, C, Renzoni, E, Lympany, P, Thomas, AQ, Roldan, J, Scott, TA, Blackwell, TS, Phillips, JA, Loyd, JE, du Bois, RM Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax, 59(11), 977-80, 2004.
• Tager, AM, Kradin, RL, LaCamera, P, Bercury, SD, Campanella, GS, Leary, CP, Polosukhin, V, Zhao, LH, Sakamoto, H, Blackwell, TS, Luster, AD Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am J Respir Cell Mol Biol, 31(4), 395-404, 2004.
• Sadikot, RT, Christman, JW, Blackwell, TS Molecular targets for modulating lung inflammation and injury. Curr Drug Targets, 5(6), 581-8, 2004.
• Maus, UA, Srivastava, M, Paton, JC, Mack, M, Everhart, MB, Blackwell, TS, Christman, JW, Schlöndorff, D, Seeger, W, Lohmeyer, J Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. J Immunol, 173(2), 1307-12, 2004.
• Park, GY, Joo, M, Pedchenko, T, Blackwell, TS, Christman, JW Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. Am J Physiol Lung Cell Mol Physiol, 286(5), L956-62, 2004.
• Joo, M, Park, GY, Wright, JG, Blackwell, TS, Atchison, ML, Christman, JW Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1. J Biol Chem, 279(8), 6658-65, 2004.
• Sadikot, RT, Zeng, H, Yull, FE, Li, B, Cheng, DS, Kernodle, DS, Jansen, ED, Contag, CH, Segal, BH, Holland, SM, Blackwell, TS, Christman, JW p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J Immunol, 172(3), 1801-8, 2004.
• Yull, FE, Han, W, Jansen, ED, Everhart, MB, Sadikot, RT, Christman, JW, Blackwell, TS Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo. J Histochem Cytochem, 51(6), 741-9, 2003.
• Gray, KD, Simovic, MO, Chapman, WC, Blackwell, TS, Christman, JW, May, AK, Parman, KS, Stain, SC Endotoxin potentiates lung injury in cerulein-induced pancreatitis. Am J Surg, 186(5), 526-30, 2003.
• Kalomenidis, I, Lane, K, Blackwell, TS, Guo, Y, Light, RW Mice are resistant to the induction of a pleurodesis. Chest, 124(6), 2407-8, 2003.
• Maus, UA, Waelsch, K, Kuziel, WA, Delbeck, T, Mack, M, Blackwell, TS, Christman, JW, Schlöndorff, D, Seeger, W, Lohmeyer, J Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J Immunol, 170(6), 3273-8, 2003.
• Sadikot, RT, Han, W, Everhart, MB, Zoia, O, Peebles, RS, Jansen, ED, Yull, FE, Christman, JW, Blackwell, TS Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J Immunol, 170(2), 1091-8, 2003.
• Gray, KD, Simovic, MO, Chapman, WC, Blackwell, TS, Christman, JW, Washington, MK, Yull, FE, Jaffal, N, Jansen, ED, Gautman, S, Stain, SC Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. J Surg Res, 110(1), 310-4, 2003.
• Lee, YC, Lane, KB, Zoia, O, Thompson, PJ, Light, RW, Blackwell, TS Transforming growth factor-beta induces collagen synthesis without inducing IL-8 production in mesothelial cells. Eur Respir J, 22(2), 197-202, 2003.
• Sadikot, RT, Wudel, LJ, Jansen, DE, Debelak, JP, Yull, FE, Christman, JW, Blackwell, TS, Chapman, WC Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model. J Gastrointest Surg, 6(2), 264-70, 2002.
• Koay, M.A., Gao, X., Washington, M.K., Blackwell, T.S., Christman, J.W "Macrophages are necessary for maximal NF- B activation and generation of lung inflammation in response to inhaled and systemic endotoxin." Am. J. Respir. Cell Mol. Biol., 26572-578, 2002.
• Koay, MA, Gao, X, Washington, MK, Parman, KS, Sadikot, RT, Blackwell, TS, Christman, JW Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin. Am J Respir Cell Mol Biol, 26(5), 572-8, 2002.
• Koay, MA, Christman, JW, Wudel, LJ, Allos, T, Cheng, DS, Chapman, WC, Blackwell, TS Modulation of endotoxin-induced NF-kappa B activation in lung and liver through TNF type 1 and IL-1 receptors. Am J Physiol Lung Cell Mol Physiol, 283(6), L1247-54, 2002.
• Maus, UA, Koay, MA, Delbeck, T, Mack, M, Ermert, M, Ermert, L, Blackwell, TS, Christman, JW, Schlöndorff, D, Seeger, W, Lohmeyer, J Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol, 282(6), L1245-52, 2002.
• Blackwell, TS, Christman, JW Defining the lung''s response to endotoxin. Am J Respir Crit Care Med, 163(7), 1516-7, 2001.
• Blackwell, TS, Stecenko, AA, Christman, JW Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder. Am J Physiol Lung Cell Mol Physiol, 281(1), L69-70, 2001.
• Stecenko, AA, King, G, Torii, K, Breyer, RM, Dworski, R, Blackwell, TS, Christman, JW, Brigham, KL Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation, 25(3), 145-55, 2001.
• Sadikot, R.T., Jansen, E.D., Blackwell, T.R., Zoia, O., Yull, F.E., Christman, J.W., Blackwell, T.S "High dose dexamethasone accentuates NF- B activation in endotoxin-treated mice." Am. J. Respir. Crit. Care Med., (164), 873-878, 2001.
• Sadikot, RT, Jansen, ED, Blackwell, TR, Zoia, O, Yull, F, Christman, JW, Blackwell, TS High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. Am J Respir Crit Care Med, 164(5), 873-8, 2001.
• Koay, A., Christman, J.W., Segal, B.H., Venkatakrishnan, A., Blackwell, T.R., Holland, S.M., Blackwell, T.S "Impaired pulmonary NF- B activation in response to lipopolysaccharide in NADPH oxidase-deficient mice." Infection and Immunity, (69), 5991-5996, 2001.
• Koay, MA, Christman, JW, Segal, BH, Venkatakrishnan, A, Blackwell, TR, Holland, SM, Blackwell, TS Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infect Immun, 69(10), 5991-6, 2001.
• Curran, CL, Blackwell, TS, Christman, JW NF-kappaB: a therapeutic target in inflammatory diseases. Expert Opin Ther Targets, 5(2), 197-204, 2001.
• Lancaster, LH, Christman, JW, Blackwell, TR, Koay, MA, Blackwell, TS Suppression of lung inflammation in rats by prevention of NF-kappaB activation in the liver. Inflammation, 25(1), 25-31, 2001.
• Sadikot, RT, Christman, JW, Blackwell, TS Chemokines and chemokine receptors in pulmonary diseases. Curr Opin Investig Drugs, 1(3), 314-20, 2000.
• Venkatakrishnan A., King G., Stecenko A.A., Blackwell T.R., Brigham K.L., Christman J.W., and Blackwell T.S "Exaggerated activation of NF- B and altered I B- processing in cystic fibrosis bronchial epithelial cells." Am. J. Respir. Cell Mol. Biol., 23396-403, 2000.
• Venkatakrishnan, A, Stecenko, AA, King, G, Blackwell, TR, Brigham, KL, Christman, JW, Blackwell, TS Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol, 23(3), 396-403, 2000.
• Chapman, WC, Debelak, JP, Wright Pinson, C, Washington, MK, Atkinson, JB, Venkatakrishnan, A, Blackwell, TS, Christman, JW Hepatic cryoablation, but not radiofrequency ablation, results in lung inflammation. Ann Surg, 231(5), 752-61, 2000.
• Chapman, WC, Debelak, JP, Blackwell, TS, Gainer, KA, Christman, JW, Pinson, CW, Brigham, KL, Parker, RE Hepatic cryoablation-induced acute lung injury: pulmonary hemodynamic and permeability effects in a sheep model. Arch Surg, 135(6), 667-72; discussion 672-3, 2000.
• Blackwell, T.S., Yull, F.E., Chen, C-L., Venkatakrishnan, A., Blackwell, T.R., Hicks, D.J., Lancaster, L.H., Christman, J.W., Kerr, L.D "Multi-organ NF- B activation in a transgenic mouse model of systemic inflammation." Am. J. Respir. Crit. Care Med. , 1621095-1101, 2000.
• Blackwell, TS, Yull, FE, Chen, CL, Venkatakrishnan, A, Blackwell, TR, Hicks, DJ, Lancaster, LH, Christman, JW, Kerr, LD Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation. Am J Respir Crit Care Med, 162(3 Pt 1), 1095-101, 2000.
• Blackwell, TS, Christman, JW, Hagan, T, Price, P, Edens, T, Morris, PE, Wolff, SN, Goodman, SA, Christman, BW Oxidative stress and NF-kappaB activation: correlation in patients following allogeneic bone marrow transplantation. Antioxid Redox Signal, 2(1), 93-102, 2000.
• Christman, JW, Blackwell, TS, Juurlink, BH Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses. Brain Pathol, 10(1), 153-62, 2000.
• Christman, JW, Sadikot, RT, Blackwell, TS The role of nuclear factor-kappa B in pulmonary diseases. Chest, 117(5), 1482-7, 2000.
• Blackwell, T.S., Lancaster, L.H., Blackwell, T.R., Venkatakrishnan, A., Christman, J.W "Chemotactic gradients predict neutrophilic alveolitis in endotoxin treated rats." Am. J. Respir. Crit. Care Med., 1591644-1652, 1999.
• Blackwell, T.S., Debelak, J.P., Venkatakrishnan, A., Schot, D.J., Harley, D.H., Pinson, C.W., Williams, P., Washington, K., Christman, J.W., Chapman, W.C "Acute lung injury after hepatic cryoablation: correlation with NF- B activation and cytokine production." Surgery, 126518-526, 1999.
• Blackwell, TS, Debelak, JP, Venkatakrishnan, A, Schot, DJ, Harley, DH, Pinson, CW, Williams, P, Washington, K, Christman, JW, Chapman, WC Acute lung injury after hepatic cryoablation: correlation with NF-kappa B activation and cytokine production. Surgery, 126(3), 518-26, 1999.
• Blackwell, TS, Lancaster, LH, Blackwell, TR, Venkatakrishnan, A, Christman, JW Chemotactic gradients predict neutrophilic alveolitis in endotoxin-treated rats. Am J Respir Crit Care Med, 159(5 Pt 1), 1644-52, 1999.
• Blackwell, T.S., Lancaster, L.H., Blackwell, T.R., Venkatakrishnan, A., Christman, J.W "Differential NF- B activation after intratracheal endotoxin: correlation with cytokine gene expression and neutrophilic alveolitis." Am. J. Physiol, 277L823-L830, 1999.
• Blackwell, TS, Lancaster, LH, Blackwell, TR, Venkatakrishnan, A, Christman, JW Differential NF-kappaB activation after intratracheal endotoxin. Am J Physiol, 277(4 Pt 1), L823-30, 1999.
• Blackwell, TS, Yull, FE, Chen, CL, Venkatakrishnan, A, Blackwell, TR, Hicks, DJ, Lancaster, LH, Christman, JW, Kerr, LD Use of genetically altered mice to investigate the role of nuclear factor-kappa B activation and cytokine gene expression in sepsis-induced ARDS. Chest, 116(1 Suppl), 73S-74S, 1999.
• Christman, JW, Lancaster, LH, Blackwell, TS Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med, 24(11), 1131-8, 1998.
• Blackwell, TS, Blackwell, TR, Christman, JW Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J Immunol, 158(12), 5934-40, 1997.
• Blackwell, TS, Blackwell, TR, Christman, JW Induction of endotoxin tolerance depletes nuclear factor-kappaB and suppresses its activation in rat alveolar macrophages. J Leukoc Biol, 62(6), 885-91, 1997.
• Blackwell, TS, Christman, JW The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol, 17(1), 3-9, 1997.
• Blackwell, TS, Blackwell, TR, Holden, EP, Christman, BW, Christman, JW In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol, 157(4), 1630-7, 1996.
• Blackwell, TS, Christman, JW Sepsis and cytokines: current status. Br J Anaesth, 77(1), 110-7, 1996.
• Blackwell, TS, Gossage, JR Gold pulmonary toxicity in a patient with a normal chest radiograph. South Med J, 88(6), 644-6, 1995.
• Christman, JW, Holden, EP, Blackwell, TS Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit Care Med, 23(5), 955-63, 1995.
• Blackwell, TS, Holden, EP, Blackwell, TR, DeLarco, JE, Christman, JW Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor kappa B activation. Am J Respir Cell Mol Biol, 11(4), 464-72, 1994.

Education

• M.D. - University of Alabama at Birmingham, 1988
• Fellowship - Vanderbilt University Medical Center, 1992
• Residency - Washington University Medical Center, 1991
• Internship - Washington University Medical Center, 1989