Yu Shyr, Ph.D.
VICC Associate Director for Quantitative Sciences Integration
Professor and Chief, Division of Cancer Biostatistics, Department of Biostatistics
Director, VICC Cancer Biostatistics Center
Ingram Professor of Cancer Research
Vanderbilt University Medical Center
571 Preston Building
Nashville, TN 37232-6848
Yu Shyr received his PhD in biostatistics from University of Michigan (Ann Arbor) in 1994 and subsequently joined the faculty at Vanderbilt University School of Medicine. At Vanderbilt, he has collaborated on numerous research projects; assisted investigators in developing clinical research protocols; collaborated on multiple grants funded through external peer-reviewed mechanisms; and developed biostatistical methodologies for clinical trial design, high-dimensional data preprocessing, estimating relative potency in a parallel line bioassay, and other statistical approaches, published in journals such as Statistics in Medicine, Bioinformatics, Clinical Trials, Computational Statistics and Data Analysis, BMC Bioinformatics, and Journal of Bioinformatics and Computational Biology in the last three years.
Dr. Shyr has delivered more than 150 abstracts at professional meetings and published more than 225 peer-reviewed papers in a variety of journals. He has served as a member of the NCI Developmental Therapeutics Study Section and the Population and Patient-oriented Training subcommittee; he also has served on numerous NIH/NCI SPORE, P01, and CCSG review panels/committees, as well as the epidemiology section of the U.S. Army Medical Research and Materiel Command Breast Cancer Research Program (BCRP) and an FDA advisory committee (voting member). Dr. Shyr has presented as an invited faculty member in the ASCO Educational Section on Advanced Concepts in Clinical Trial Design and Methodology and, since 2004, has been a member of the invited faculty at the AACR/ASCO Methods in Clinical Cancer Research Workshop. He currently serves on the external advisory board for Northwestern University¿s Robert H. Lurie Comprehensive Cancer Center; is a member of the editorial board for the Journal of Clinical Oncology and Cancer Prevention Research Journal as well as ASCO¿s Cancer Research Committee; and directs the biostatistics cores for the NCI-funded Vanderbilt University Breast Cancer SPORE, GI Cancer SPORE, Lung Cancer SPORE, and other program projects. Dr. Shyr¿s current research interests lie in developing and analyzing predictive models of the statistical relationships between multiple-variable protein and RNA expression data and clinical endpoints using both supervised and unsupervised classification and pattern recognition approaches, which focus on analyses of gene expression array and protein expression profile data to identify the molecular "fingerprint" of different types of cancers.