The VICC.ORG Investigator Directory

Zhaozhong Han, Ph.D.

Assistant Professor
VICC Member
Researcher


Vanderbilt-Ingram Cancer Center Radiation Oncology
22nd at Pierce Avenue, B1034
Nashville, TN 37232-5671
Phone: 615-322-2555
Fax: 615-343-3075

Contact Information:

Vanderbilt Department of Radiation Oncology
Medical Center North, E1220
Nashville, TN 37232-5671
615-322-1167
Fax: 615-343-0161

Research Specialty:

molecular cancer pathology, metastasis, cell migration and invasion, tumor microenvironment, angiogenesis, DNA damage repair, Biomarker discovery and development, Phage display, Protein engineering, Cellular and molecular imaging of cancer, Targeting drug delivery, Therapeutic peptide or protein

Research Description:

The past decades have witnessed the dramatic development in molecular targeted therapy for cancers. Treatments approved for targeting molecular events within cancers include those modulating cell survival, proliferation, invasion, metastasis and angiogenesis. However, patients respond to the molecular targeted therapy with a broad spectrum of efficacy because of the biological heterogeneity of cancers. It is increasingly important to understand systematically how cancer cells respond to the treatment so that the tumor responsiveness can be monitored and the personalized treatment can be justified in time. This lab is devoted to investigate and develop such treatment-inducible molecular signatures within tumors for cancer imaging, drug delivery and drug discovery. Currently, we are interested in how cancers respond to tyrosine kinase inhibitors (TKIs) and ionizing radiation (IR). Ongoing projects in this lab include: 1) biomarker discovery. We are using phage-displayed peptides, engineered protein scaffolds and antibody fragments to profile the TKIs/IR-induced changes in the plasma membrane proteome of cancer cells; 2) molecular and cellular imaging to assess tumor response to TKIs/IR treatment; 3) tumor-targeted drug delivery; 4) biological function of tax-interacting protein 1 (TIP-1) within cancer cells, especially its roles in cancer cell response to chemotherapy and radiotherapy, local invasion and long distance metastasis, and angiogenesis. The long term goal is to develop tools and rationales to personalize molecular targeted therapy for cancer patients.

Publications:

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