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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

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Program Leaders


​R. Daniel Beauchamp, M.D.


Jordan D. Berlin, M.D.

 

Gastrointestinal Cancer

 

The GI Cancer Program is a translational/clinical program within the Cancer Center.  Since the inception of the Vanderbilt-Ingram Cancer Center, the GI Program has evolved and grown from a program with a scientific focus on colorectal cancer to one that clinically encompasses all GI cancers and scientifically encompasses in-depth research initiatives in colorectal, gastroesophageal and pancreas cancers.  The highlight of the colorectal cancer initiative remains the Specialized Project of Research Excellence (SPORE) grant now in its 12th year, still the only one focused exclusively on colorectal cancer, the second leading cause of cancer death in the United States. The highly successful gastroesophageal initiative has two active PO1 grants as well as multiple RO1 and other high impact grants.  A foundation of this initiative is the better understanding of H. Pylori in the development of gastric cancer and the role of inflammation in malignant transformation.   The pancreas initiative began at the time of the last CCSG renewal and has been growing rapidly with a bimonthly meeting to increase collaborative work among the pancreas cancer researchers at VICC.  To help this initiative, the GI SPORE successfully competed its first pancreas cancer-specific Pilot Project Award and supported a retreat in 2014.

Scientific Goals

  • Specific Aim 1: Elucidate the etiology and pathogenesis of gastrointestinal cancers
  • Specific Aim 2: Develop biomarkers and imaging techniques to improve detection and predict efficacy of current and novel therapeutics for gastrointestinal cancers.
  • Specific Aim 3: Develop and study novel laboratory models of cancer to improve understanding of human cancers
  • Specific Aim 4: Translate laboratory discoveries into clinical investigations.

About the Program Leaders

R. Daniel Beauchamp, M.D., F.A.C.S., John Clinton Foshee Distinguished Professor of Surgery, Chairman of the Section of Surgical Sciences, Surgeon-in-Chief at Vanderbilt University and Deputy Director of the Vanderbilt-Ingram Cancer Center is serving as interim co-Director of GI Oncology.  He holds joint appointments as professor in the departments of Cell and Developmental Biology and Cancer Biology. He also serves as Deputy Director of the Vanderbilt-Ingram Cancer Center. Dr. Beauchamp has two active R01 grants from NCI, and is a co-leader of Project 3 in the GI Cancer SPORE. Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.

Jordan D. Berlin, M.D., Ingram Professor of Cancer Research, remains the other co-director of the GI Program. He is a clinical-translational researcher in Medical Oncology, Director of Phase I Research and Principal Investigator of the recently awarded Lead Academic Participating Site grant for the National Clinical Trials Network as well as the Site PI for the ViKTriY Phase I UM1 grant (P. Lorusso, PI).  Dr. Berlin is the co-PI of the GI Cancer SPORE and co-PI of project 2 of the GI SPORE.  He served as Chair of the Intergroup Task Force on Pancreatic Cancer from 2006-2013 and has served on the program committee for the World GI Congress, American Society of Clinical Oncology, Gastrointestinal Cancers Symposium and the World Conference on Interventional Oncology.

Program Members

  • Andl, Claudia D., Ph.D.
    Assistant Professor of Cancer Biology; Assistant Professor of Surgery (Surgical Oncology); Researcher
  • Beauchamp, R. Daniel, M.D., F.A.C.S.
    John Clinton Foshee Distinguished Professor of Surgery (Surgical Oncology); Chairman, Section of Surgical Sciences; Surgeon-in-Chief, Vanderbilt University Hospital; Deputy Director, Vanderbilt-Ingram Cancer Center; Surgical Oncologist
  • Berlin, Jordan D., M.D.
    Ingram Professor of Cancer Research and Professor of Medicine (Hematology/Oncology); Medical Director of Clinical Trials Shared Resources; Clinical Director, GI Oncology Program; Director, Phase I Program; Medical Oncologist
  • Cardin, Dana Backlund, M.D., MSCI
    Assistant Professor of Medicine (Hematology/Oncology); Medical Oncologist
  • Chan, Emily, M.D., Ph.D.
    Assistant Professor of Medicine (Hematology/Oncology); Medical Oncologist
  • Coffey, Robert J., M.D.
    Ingram Professor of Cancer Research; Professor of Medicine (Gastroenterology, Hepatology and Nutrition); Professor of Cell and Developmental Biology; Researcher
  • Correa, Pelayo, M.D.
    Anne Potter Wilson Professor of Medicine (Pathology, Microbiology and Immunology); Anatomic Pathologist
  • Cover, Timothy L., M.D.
    Professor of Medicine (Infectious Disease); Researcher
  • Deane, Natasha G., Ph.D.
    Research Associate Professor of Surgery; Researcher
  • El-Rifai, Wael, M.D., Ph.D.
    H. William Scott, Jr. Professor of Surgery; Director, Surgical Oncology Research; Professor of Cancer Biology; Cancer Geneticist; Molecular Biologist
  • Franklin, Jeffrey L., Ph.D.
    Research Assistant Professor of Cell and Developmental Biology ; Researcher
  • Goff, Laura Williams, M.D.
    Assistant Professor of Medicine (Hematology/Oncology); Associate Director, Hematology/Oncology Fellowship Program; Medical Oncologist
  • Goldenring, James R., M.D., Ph.D.
    Paul W. Sanger Professor of Experimental Surgery; Vice-Chairman for Research; Researcher
  • Gorden, David Lee, M.D. , F.A.C.S.
    Professor of Surgery (Hepatobiliary and Liver Transplantation); Liver and Hepatobiliary Surgeon
  • Idrees, Kamran, M.D.
    Assistant Professor of Surgery (Surgical Oncology)
  • Lee, Ethan, M.D., Ph.D.
    Associate Professor of Cell and Development Biology; Researcher
  • Liebler, Daniel (Dan) C., Ph.D.
    Director, Center in Molecular Toxicology; Director, Jim Ayers Institute for Precancer Detection and Diagnosis; Ingram Professor of Cancer Research; Professor of Biochemistry, Pharmacology, and Biomedical Informatics; Researcher
  • Manning, H. Charles, Ph.D.
    Associate Professor of Radiology and Radiological Sciences; Associate Professor of Biomedical Engineering; Associate Professor of Neurological Surgery; Director of Molecular Imaging Research; Researcher
  • Means, Anna L., Ph.D.
    Research Assistant Professor of Surgical Oncology; Assistant Professor of Cell & Developmental Biology; Surgical Oncologist
  • Merchant, Nipun B., M.D.
    Professor of Surgical Oncology; Gastrointestinal Surgical Oncologist
  • Murff, Harvey J., M.D., M.P.H.
    Associate Professor of Medicine (General Internal Medicine and Public Health); Researcher
  • Omary, Reed A., M.D., M.S.
    Carol D. & Henry P. Pendergrass Professor and Chair, Dept of Radiology and Radiological Sciences; Chair, Department of Radiology & Radiological Sciences
  • Parikh, Alexander A., M.D.
    Assistant Professor of Surgical Oncology; Surgical Oncologist
  • Pearson, A. Scott, M.D., Ph.D.
    Associate Professor of Surgical Oncology; Researcher
  • Peek, Richard, Jr., M.D.
    Mina Cobb Wallace Professor of Immunology; Professor of Medicine (Gastroenterology, Hepatology & Nutrition); Professor of Cancer Biology; Director of Gastroenterology, Hepatology & Nutrition; Researcher
  • Reynolds, Albert B., Ph.D.
    Ingram Professor of Cancer Research; Professor of Cancer Biology; Executive Director, Vanderbilt Antibody and Protein Resource (VAPR) ; Program Director, VICC Signal Transduction & Cell Proliferation Research Program; Researcher
  • Shi, Chanjuan, M.D., Ph.D.
    Assistant Professor of Pathology, Microbiology and Immunology
  • Singh, Amar B., Ph.D.
    Assistant Professor of Medicine (Nephrology); Researcher
  • Tarpley, John L., M.D.
    Professor of Surgery, Anesthesiology; Program Director, General Surgery Residency Program; Surgical Oncologist
  • Vaezi, Michael F., M.S., M.D., Ph.D.
    Professor of Medicine (Gastroenterology, Hepatology, & Nutrition); Researcher
  • Washington, M. Kay, M.D., Ph.D.
    Professor of Pathology, Microbiology and Immunology; Pathologist
  • Wiesner, Georgia L., M.D., M.S.
    Ingram Professor of Cancer Research; Professor of Genetic Medicine; Director, Clinical and Translational Hereditary Cancer Program; Cancer Geneticist
  • Williams, Christopher Shawn, M.D., Ph.D.
    Assistant Professor of Medicine (Gastroenterology, Hepatology & Nutrition); Assistant Professor of Cancer Biology; Researcher
  • Wilson, Keith T., M.D.
    Thomas F. Frist, Sr. Professor of Medicine (Gastroenterology, Hepatology & Nutrition); Professor of Cancer Biology; Director of Research and Fellowship Training Program, Division of Gastroenterology, Hepatology, & Nutrition; Researcher
  • Wright, Christopher V., Ph.D.
    Louise B. McGavock Professor of Cell & Developmental Biology; Researcher
  • Zaika, Alexander, Ph.D.
    Associate Professor of Cancer Biology; Associate Professor of Surgery (Surgical Research); Assistant Professor of Cancer Biology; Researcher