The Gastrointestinal Cancer Research Program (GI) is a translational/clinical program within the Cancer Center. Since the inception of the Vanderbilt-Ingram Cancer Center, the GI Program has evolved and grown from a program with a scientific focus on colorectal cancer to one that clinically encompasses all GI cancers and scientifically encompasses in-depth research initiatives in colorectal, gastroesophageal and pancreas cancers. The highlight of the colorectal cancer initiative remains the Specialized Project of Research Excellence (SPORE) grant now in its 13th year, still the only one focused exclusively on colorectal cancer, the second leading cause of cancer death in the United States. The highly successful gastroesophageal initiative has two active PO1 grants as well as multiple RO1 and other high impact grants. A foundation of this initiative is the better understanding of H. Pylori in the development of gastric cancer and the role of inflammation in malignant transformation. The pancreas initiative began at the time of the last CCSG renewal and has been growing rapidly with a bimonthly meeting to increase collaborative work among the pancreas cancer researchers at VICC. To help this initiative, the GI SPORE successfully competed its first pancreas cancer-specific Pilot Project Award and supported a retreat in 2014.
- Specific Aim 1: Elucidate the etiology and pathogenesis of gastrointestinal cancers
- Specific Aim 2: Develop biomarkers and imaging techniques to improve detection and predict efficacy of current and novel therapeutics for gastrointestinal cancers
- Specific Aim 3: Develop and study novel laboratory models of cancer to improve understanding of human cancers
- Specific Aim 4: Translate laboratory discoveries into clinical investigations
R. Daniel Beauchamp, M.D., F.A.C.S., John Clinton Foshee Distinguished Professor of Surgery, Chairman of the Section of Surgical Sciences, Surgeon-in-Chief at Vanderbilt University and Deputy Director of the Vanderbilt-Ingram Cancer Center is serving as interim co-Director of GI Oncology. He holds joint appointments as professor in the departments of Cell and Developmental Biology and Cancer Biology. He also serves as Deputy Director of the Vanderbilt-Ingram Cancer Center. Dr. Beauchamp has two active R01 grants from NCI, and is a co-leader of Project 3 in the GI Cancer SPORE. Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.
Jordan D. Berlin, M.D., Ingram Professor of Cancer Research, remains the other co-director of the GI Program. He is a clinical-translational researcher in Medical Oncology, Director of Phase I Research and Principal Investigator of the recently awarded Lead Academic Participating Site grant for the National Clinical Trials Network as well as the Site PI for the ViKTriY Phase I UM1 grant (P. Lorusso, PI). Dr. Berlin is the co-PI of the GI Cancer SPORE and co-PI of project 2 of the GI SPORE. He served as Chair of the Intergroup Task Force on Pancreatic Cancer from 2006-2013 and has served on the program committee for the World GI Congress, American Society of Clinical Oncology, Gastrointestinal Cancers Symposium and the World Conference on Interventional Oncology.
- Algood, Holly M. , Ph.D.
Assistant Professor of Medicine (Infectious Diseases); Assistant Professor Pathology, Microbiology and Immunology; Research Microbiologist
- Beauchamp, R. Daniel, M.D., F.A.C.S.
Deputy Director, Vanderbilt-Ingram Cancer Center ; Co-Leader, Gastrointestinal Cancer Research Program; John Clinton Foshee Distinguished Professor of Surgery (Surgical Oncology); Chair, Section of Surgical Sciences ; Surgeon-in-Chief, Vanderbilt University Hospital; Surgical Oncologist
- Berlin, Jordan D., M.D.
Co-Leader, Gastrointestinal Cancer Research Program; Ingram Professor of Cancer Research; Professor of Medicine (Hematology/Oncology); Director, Phase I Program; Medical Oncologist
- Bordenstein, Seth, Ph.D.
Associate Professor of Biological Sciences; Associate Professor of Pathology, Microbiology & Immunology; Pathologist
- Brown, Daniel B. , M.D.
Professor of Radiology and Radiological Sciences; Director, Interventional Oncology; Interventional Radiologist
- Cardin, Dana B, M.D., MSCI
Assistant Professor of Medicine (Hematology/Oncology); Medical Oncologist
- Chakravarthy, Anuradha (Bapsi), M.D.
Professor, Program Director ; Professor of Radiation Oncology; Radiation Oncologist
- Chan, Emily, M.D., Ph.D.
Associate Professor of Medicine (Hematology/Oncology); Medical Oncologist
- Coffey, Robert J., M.D.
Ingram Professor of Cancer Research; Professor of Medicine (Gastroenterology, Hepatology and Nutrition); Professor of Cell and Developmental Biology; Researcher
- Cover, Timothy L., M.D.
Professor of Medicine (Infectious Disease); Researcher
- El-Rifai, Wael, M.D., Ph.D.
H. William Scott, Jr. Professor of Surgery; Director, Surgical Oncology Research; Professor of Surgery and Cancer Biology; Cancer Geneticist; Molecular Biologist
- Franklin, Jeffrey L., Ph.D.
Research Assistant Professor of Cell and Developmental Biology ; Researcher
- Goff, Laura Williams, M.D.
Assistant Professor of Medicine (Hematology/Oncology); Associate Director, Hematology/Oncology Fellowship Program; Medical Oncologist
- Goldenring, James R., M.D., Ph.D.
Paul W. Sanger Professor of Experimental Surgery; Vice-Chairman for Research; Researcher
- Gorden, David Lee, M.D. , F.A.C.S.
Professor of Surgery (Hepatobiliary and Liver Transplantation); Liver and Hepatobiliary Surgeon
- Idrees, Kamran, M.D.
Assistant Professor of Surgery (Surgical Oncology); Surgical Oncologist
- Kachnic, Lisa A., M.D.
Professor and Chair of Radiation Oncology
- Lee, Ethan, M.D., Ph.D.
Professor of Cell and Developmental Biology; Professor of Cancer Biology; Associate Professor of Pharmacology; Researcher
- Liebler, Daniel C., Ph.D.
Director, Jim Ayers Institute for Precancer Detection and Diagnosis; Ingram Professor of Cancer Research; Professor of Biochemistry, Pharmacology, and Biomedical Informatics; Director, Center in Molecular Toxicology; Researcher
- Manning, H. Charles, Ph.D.
Ingram Professor of Cancer Research; VICC Director of Cancer Imaging Research; Director, Vanderbilt Center for Molecular Probes and Molecular Imaging Research; Professor of Radiology, Chemistry, Biomedical Engineering, Neurosurgery, and Chemical and Physical Biology; Researcher
- Means, Anna L., Ph.D.
Research Associate Professor of Surgery; Assistant Professor of Cell & Developmental Biology; Surgical Oncologist
- Morgan, Douglas R. , M.D., M.P.H.
Associate Professor of Medicine
- Murff, Harvey J., M.D., M.P.H.
Associate Professor of Medicine (General Internal Medicine and Public Health); Researcher
- Omary, Reed A., M.D., M.S.
Carol D. & Henry P. Pendergrass Professor and Chair, Dept of Radiology and Radiological Sciences; Chair, Department of Radiology & Radiological Sciences; Interventional Radiologist
- Parikh, Alexander A., M.D., M.P.H.
Associate Professor of Surgery; Director of Hepatobiliary, Pancreatic and Surgical Oncology; Director, Vanderbilt Pancreas Center; Surgical Oncologist
- Peek, Richard, Jr., M.D.
Mina Cobb Wallace Professor of Medicine and Cancer Biology; Director, Division of Gastroenterology, Hepatology & Nutrition; Director, Digestive Disease Research Center; Researcher
- Reynolds, Albert B., Ph.D.
Ingram Professor of Cancer Research; Professor of Cancer Biology; Executive Director, Vanderbilt Antibody and Protein Resource (VAPR) ; Researcher
- Shi, Chanjuan, M.D., Ph.D.
Assistant Professor of Pathology, Microbiology and Immunology; Pathologist
- Vaezi, Michael F., M.S., M.D., Ph.D.
Professor of Medicine (Gastroenterology, Hepatology, & Nutrition); Researcher
- Washington, Mary Kay, M.D., Ph.D.
Professor of Pathology, Microbiology and Immunology; Pathologist
- Wiesner, Georgia L., M.D., M.S.
Director, Clinical and Translational Hereditary Cancer Program; Ingram Professor of Cancer Research; Professor of Medicine; Cancer Geneticist
- Williams, Christopher Shawn, M.D., Ph.D.
Associate Professor of Medicine (Gastroenterology, Hepatology & Nutrition); Associate Professor of Cancer Biology; Researcher
- Wilson, Keith T., M.D.
Thomas F. Frist, Sr. Professor of Medicine (Gastroenterology, Hepatology & Nutrition); Professor of Cancer Biology; Director of Research and Fellowship Training Program, Division of Gastroenterology, Hepatology, & Nutrition; Researcher
- Wright, Christopher V., Ph.D.
Louise B. McGavock Professor of Cell & Developmental Biology; Researcher
- Zaika, Alexander, Ph.D.
Associate Professor of Cancer Biology; Associate Professor of Surgery (Surgical Oncology); Assistant Professor of Cancer Biology; Researcher