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Program Leaders

Madan Jagasia, M.B.B.S.
Young Kim, M.D., Ph.D.

Translational Research and Interventional Oncology

The Translational Research and Interventional Oncology Research Program (TR) promotes, develops and exploits mechanism-based research for improved detection and therapy of human cancer. This program is dedicated to:

  • New discoveries in early detection and molecular oncology, including the creation of the Lung Nodule Clinic, a translational laboratory for early detection and Early Detection Research Network funded research which allows for increased collection and analysis of early lesions and indeterminate pulmonary nodules (IPNs) and provides a platform for interventional studies.
  • Genotype-driven early phase trials, including exceptional responders and mechanisms of resistance and immune mechanisms in cancer and cellular therapy.

Scientific Goals

  • To translate advances in our understanding of molecular mechanisms of oncogenesis and tumor progression into novel therapeutic strategies.With primary focus on lung cancer, melanoma, and lymphoma/leukemia, we will use the strength of in-depth molecular and phenotypic characterization of tumor heterogeneity to identify new targets and translate those into new therapeutic opportunities.
  • To further develop genetically directed early phase clinical trials – in part through Center for Cancer Targeted Therapeutics (C2T2), Early Cancer Therapeutics Consortium (ECTC), National Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice (MATCH). Selection of targets will be based on Next Generation Sequenced (NGS) tumors. Evaluation of response will be based on molecular imaging approaches and other biomarkers predictive not only of response but also toxicity and drug metabolism. Exceptional responders will be specifically identified through our large clinical trial based effort.
  • To understand mechanisms of resistance to genetically targeted therapy and develop novel strategies to prevent and overcome resistance.
  • To apply and enhance immune strategies in cancer and cellular therapy. We will develop adoptive cell therapy through modifications of allogeneic stem cell transplantation or through transfer of chimeric-antigen-receptor (CAR) effector T cells. We will develop a better understanding of checkpoint inhibition (anti-CTLA-4, anti-PD1) to enable the definition of alternate biomarkers of efficacy, toxicity, and resistance.

Program Leaders

Madan Jagasia, M.B.B.S., M.S., is Professor of Medicine (Hematology/Oncology) and Section Chief, Hematology and Stem Cell Transplant. He specializes in stem cell transplant for hematological malignancies (leukemia, lymphoma, myeloma, MDS) and bone marrow disorders. He is a co-leader of the Translational Research and Interventional Oncology Research Program at the Vanderbilt-Ingram Cancer Center. His research interest is graft-versus-host disease (GVHD), an immune complication after a donor stem cell transplant. Along with being the principal investigator as Core Center of Bone Marrow Transplant Clinical Trials Network, Jagasia was one of the founding members of the Chronic GVHD Consortium. As a member of the 2015 NIH Consensus Criteria for chronic GVHD steering committee, he led the effort to establish current guidelines for diagnosis and staging of chronic GVHD. He has multiple clinical trials in both acute and chronic GVHD, both observational and therapeutic. In addition, he is leading efforts to identify biomarkers of response to extracorporeal photopheresis, which is used to treat patients with chronic GVHD. He established the Long Term Transplant Clinic at Vanderbilt in 2006, which allows for systematic multidisciplinary follow up of patients after allogeneic stem cell transplant.

Young Kim, M.D., Ph.D., Associate Professor of Otolaryngology and co-leader of the Translational Research and Interventional Oncology Research Program, is a clinician-scientist focused on the development of immunotherapeutic modalities for solid tumors. As a surgeon who treats patients with head and neck cancer, Kim approaches research from a translational standpoint to understand the relationship between neoplastic transformation and the host immune response. His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

Program Members

  • Aldrich, Melinda, Ph.D., M.P.H.
    Assistant Professor of Thoracic Surgery
  • Arora, Sandeep, M.B.B.S.
    Assistant Professor of Radiology and Radiological Sciences; Assistant Professor of Urologic Surgery; Radiologist
  • Berlin, Jordan D., M.D.
    Co-Leader, Gastrointestinal Cancer Research Program; Ingram Professor of Cancer Research; Professor of Medicine (Hematology/Oncology); Director, Phase I Program; Medical Oncologist
  • Blackwell, Timothy Scott, M.D.
    Ralph and Lulu Owen Professor of Medicine (Allergy, Pulmonary, and Critical Care); Professor of Cancer Biology; Professor of Cell and Developmental Biology; Director, Division of Allergy, Pulmonary and Critical Care; Pulmonologist
  • Borinstein, Scott C., M.D., Ph. D.
    Assistant Professor of Pediatrics; (Pediatric Hematology and Oncology); Pediatric Hematologist/Oncologist
  • Chung, Dai H., M.D.
    Janie Robinson and John Moore Lee Professor of Pediatrics; Professor of Pediatric Surgery; Professor of Cancer Biology; Professor of Pediatrics; Chair, Department of Pediatric Surgery; Pediatric Surgeon
  • Clark, Stephen W., M.D., Ph.D.
    Assistant Professor of Neurology (Neuro-Oncology); Neuro-Oncologist
  • Cmelak, Anthony J., M.D.
    Professor of Radiation Oncology; Senior Medical Director, Radiation Oncology Satellites; Radiation Oncologist
  • Connelly, Jim, M.D.
    Assistant Professor of Pediatrics; Pediatric Hematologist/Oncologist
  • Cornell, R. Frank, M.D.
    Assistant Professor of Medicine (Hematology/Oncology); Hematologist/Oncologist
  • Crispens, Marta Ann, M.D.
    Associate Professor of Obstetrics and Gynecology; Gynecological Oncologist
  • Ellis, Darrel L., M.D.
    Associate Professor of Medicine (Dermatology); Dermatologist
  • Engelhardt, Brian, M.D.
    Assistant Professor of Medicine (Hematology and Oncology); Hematologist/Oncologist
  • Gilbert, Jill, M.D.
    Associate Professor of Medicine (Hematology/Oncology); Director, Hematology/Oncology Fellowship Program; Medical Oncologist
  • Goodman, Stacey A., M.D.
    Professor of Medicine (Hematology and Oncology); Director, Special Fellowship Program for Marrow Transplant; Hematologist/Oncologist
  • Grogan, Eric L., M.D., M.P.H.
    Professor of Thoracic Surgery & Medicine; Investigator, Institute for Medicine and Public Health; Thoracic Surgeon
  • Haake, Scott M., M.D.
    Instructor in Medicine
  • Ho, Richard, M.D., M.S.C.I.
    Associate Professor of Pediatrics (Pediatric Hematology and Oncology); Pediatric Hematologist/Oncologist
  • Holt, Ginger E., M.D.
    Professor of Orthopaedic Surgery and Rehabilitation; Orthopaedic Oncologist
  • Horn, Leora, M.D., M.Sc.
    Associate Professor of Medicine (Hematology and Oncology); Assistant Director, Educator Development Program; Clinical Director, Thoracic Oncology Program; Medical Oncologist
  • Jagasia, Madan, M.B.B.S., M.S.
    Co-Leader, Translational Research and Interventional Oncology Research Program ; Professor of Medicine (Hematology/Oncology); Director, Outpatient Transplant Program; Section Chief, Hematology and Stem Cell Transplant; Hematologist/Oncologist
  • Johnson, Douglas, M.D., M.S.C.I.
    Assistant Professor of Medicine; Clinical Director, Melanoma; Medical Oncologist
  • Kassim, Adetola, M.D., M.S.
    Associate Professor of Medicine (Hematology/Oncology); Director, Adult Sickle Cell Disease Program; Clinical Director, Adult Stem Cell Transplant Program; Hematologist/Oncologist
  • Katzenstein, Howard, M.D.
    Professor of Pediatrics ; Scott and Tracie Hamilton Chair in Cancer Survivorship; Medical Director, Pediatric Hematology Oncology
  • Keedy, Vicki L., M.D., MSCI
    Assistant Professor of Medicine (Hematology/Oncology); Clinical Director, Sarcoma; Medical Director, Clinical Trials Shared Resource; Medical Oncologist
  • Kim, Young Jun, M.D., Ph.D.
    Co-Leader, Translational Research and Interventional Oncology Research Program; Associate Professor of Otolaryngology
  • Kirschner, Austin, M.D., Ph.D.
    Assistant Professor of Radiation Oncology; Assistant Professor of Cancer Biology; Radiation Oncologist
  • Kitko, Carrie L., M.D.
    Associate Professor of Pediatrics and Medicine; Medical Director, Pediatric Stem Cell Transplant Program; Pediatric Hematologist/Oncologist
  • Lambright, Eric S., M.D.
    Assistant Professor of Thoracic Surgery; Surgical Director, Lung Transplant; Chief of Thoracic Surgery, VA Hospital, Nashville, TN; Thoracic Surgeon
  • Levy, Mia, M.D., Ph.D.
    Director, Cancer Health Informatics and Strategy; Ingram Assistant Professor of Cancer Research; Assistant Professor of Biomedical Informatics and Medicine (Hematology/Oncology); Medical Oncologist
  • Lovly, Christine M., M.D., Ph.D.
    Assistant Professor of Medicine (Hematology/Oncology); Assistant Professor of Cancer Biology; Medical Oncologist
  • Loyd, James E., M.D.
    Rudy W. Jacobson Professor of Medicine (Allergy, Pulmonary, and Critical Care); Director, Familial Primary Pulmonary Arterial Hypertension Registry; Director, Familial Idiopathic Pulmonary Fibrosis Registry ; Researcher
  • Massion, Pierre, M.D.
    Co-Leader, Cancer Health Outcomes and Control Research Program ; Cornelius Vanderbilt Chair in Medicine; Ingram Professor of Cancer Research; Professor of Medicine (Allergy, Pulmonary, and Critical Care) and Cancer Biology; Director, Cancer Early Detection and Prevention Initiative; Pulmonary and Critical Care Medicine Doctor
  • Mohan, Sanjay R., M.D.
    Assistant Professor of Medicine; Hematologist/Oncologist
  • Moots, Paul L., M.D.
    Associate Professor of Medicine; Associate Professor of Neurology; Neuro-Oncologist
  • Morgan, David, M.D.
    Associate Professor of Medicine (Hematology and Oncology); Hematologist/Oncologist
  • Moslehi, Javid. J. , M.D.
    Assistant Professor of Medicine; Director, Cardio-Oncology Program; Cardio-Oncologist
  • Murphy, Barbara A., M.D.
    Professor of Medicine (Hematology/Oncology); Director, Head & Neck Oncology; Program Director, Pain & Symptom Management Program; Medical Oncologist
  • Netterville, James L., M.D.
    Mark C. Smith Professor of Head and Neck Surgery, Professor of Otolaryngology; Director, Head & Neck Oncologic Surgery; Associate Director, Bill Wilkerson Center for; Otolaryngology and Communication Sciences ; Head and Neck Surgical Oncologist
  • Newman, John H., M.D.
    Elsa S. Hanigan Professor of Pulmonary Medicine; Professor of Medicine (Allergy, Pulmonary & Critical Care Medicine); Director, Pulmonary & Critical Care Fellowship Program ; Researcher
  • Oates, John A., M.D.
    Thomas F Frist, Senior Professor of Medicine (Clinical Pharmacology); Professor of Pharmacology; Chair Emeritus of the Department of Medicine; Researcher
  • Price, Ronald R., Ph.D.
    Professor of Radiology and Radiological Sciences; Professor of Physics and Astronomy; Researcher
  • Rathmell, W. Kimryn (Kim) , M.D., Ph.D.
    Director, Division of Hematology/Oncology; Cornelius A. Craig Professor of Medicine; Professor of Clinical Medicine and Cancer Biology; Medical Oncologist
  • Reddy, Nishitha M., M.B.B.S., MsCI
    Associate Professor of Medicine (Hematology/Oncology); Hematologist/Oncologist
  • Rickman, Otis B., D.O.
    Assistant Professor of Medicine (Allergy, Pulmonary and Critical Care); Interventional Pulmonologist
  • Savani, Bipin N., M.D.
    Professor of Medicine (Hematology and Oncology); Director, Long Term Transplant Clinic; Medical Director, Stem Cell Transplant Processing Laboratory; Hematologist/Oncologist
  • Savona, Michael R. , M.D.
    Associate Professor of Medicine; Director, Hematology Early Therapeutics Program
  • Sengsayadeth, Salyka, M.D.
    Assistant Professor of Medicine; Hematologist/Oncologist
  • Slosky, David A., M.D.
    Assistant Professor of Medicine and Emergency Medicine
  • Stabin, Michael, Ph.D., CHP
    Associate Professor of Radiology and Radiological Sciences; Researcher
  • Strickland, Stephen A., Jr., M.D., MSCI
    Assistant Professor of Medicine (Hematology/Oncology); Hematologist/Oncologist
  • Thompson, Reid C., M.D.
    William F. Meacham Professor and Chairman of Neurological Surgery; Director of the Vanderbilt Brain Tumor Center; Director, Neurosurgical Oncology; Professor of Otolaryngology; Neurosurgical Oncologist
  • Volanakis, Emmanuel J., M.D.
    Assistant Professor of Pediatrics (Pediatric Hematology and Oncology); Pediatric Hematologist/Oncologist
  • Walker, Ronald C. , M.D.
    Professor of Clinical Radiology & Radiological Sciences; Researcher
  • Warner, Jeremy L., M.D., M.S.
    Medical Director, Vanderbilt Cancer Registry; Assistant Professor of Medicine and Biomedical Informatics; Hematologist/Oncologist
  • Worrell, John A., M.D.
    Professor of Radiology and Radiological Sciences; Radiologist
  • Zhu, Jing, Ph.D.
    Research Assistant Professor of Surgery

Program Leaders

Madan Jagasia, M.B.B.S.
Young Kim, M.D., Ph.D.