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Pathology and Tissue Informatics Core

Specific Aims

  1. To consent, collect, de-identify, process, bank and distribute annotated, high-quality breast tumor, blood and urine samples from patients participating in SPORE clinical trials and/or enrolled in the Vanderbilt Breast Tissue/Body Fluids Repository protocol, while protecting patient confidentiality by de-identification of specimens upon distribution.

  2. To perform rigorous quality control by a breast pathologist on all distributed tissues to ensure that adequate, high-quality tissue appropriate for the research application is supplied to the investigator and to provide oversight on optimal utilization of each sample.

  3. To provide SPORE investigators with specialized technical and interpretative histology services including:

    • expertise in developing, performing and evaluating IHC and FISH; 

    • planning and tissue selection for construction of tissue microarrays; and 

    • pathologist-guided laser capture microdissection (LCM) services.

  4. To partner with the Vanderbilt Ingram Cancer Center (VICC) Informatics Shared Resource (ISR) to provide a strategy for collection, histopathological and clinical annotation, tracking and distribution of breast tissues for translational research conducted by SPORE investigators. This strategy includes developing and maintaining informatics tools for a virtual tissue repository with specimen-specific information as well as links to IHC, FISH, gene array and sequencing data, permitting queries to inform future studies.