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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

Cores

Administrative Core

The Administrative Core is responsible for managing the SPORE resources and facilitating communications between the SPORE components, other collaborators, and with other SPORES and the NCI. This is accomplished through a series of oversight committees, organized administrative and scientific meetings of SPORE investigators, institutional representatives and external reviewers.

Biorepository Core

The specific aims of this proposal are:

  1. To collect, process, bank, and distribute tissue removed from lung cancer patients with normal control lung as outlined in the appropriate research informed consent, and to preserve these tissues frozen, formalin-fixed and paraffin-embedded, and on cytologic preparations (cytospins or touch imprints) to support lung SPORE projects.
  2. To maintain a centralized, computerized database of all specimens with basic demographic and pathologic information to permit the integration of findings by SPORE investigators through molecular assays and other laboratory studies with risk factor data and follow-up.
  3. To maintain the confidentiality and integrity of the database through keyed numeric identifiers assigned by the tissue core for each specimen.
  4. To provide high quality control of all well-characterized tissues in both human and murine with respect to preservation and histopathologic characterization.
  5. To provide cytology expertise to lung SPORE projects.
  6. To provide tissue microarray services to lung SPORE investigators.
  7. To provide laser microdissection to the SPORE investigators
  8. To provide expertise in developing, performing and evaluation of immunohistochemical stains and quantitation in both human and murine tissues.

The tissue core relies on support services already established at Vanderbilt University Medical Center (VUMC), including the Tissue Acquisition Shared Resource of the Vanderbilt-Ingram.

Biostatistics Core

The purpose of the Biostatistics Core is to provide professional expertise in statistics for all Vanderbilt University Lung Cancer SPORE projects, investigators and participants. Functions provided by this core include development of experimental designs, data quality control, statistical analysis and interpretation of findings, and collaboration on presentation of results. To achieve these functions, the core director and core biostatisticians are constantly available to investigators, and are in regular contact with the project and core leaders.

The primary objectives of the Biostatistics Core are:

  1. To provide study design and review all laboratory, animal and clinical studies including feasibility assessment, power analysis and sample size estimation.
  2. To collaborate in projects data analysis, interpretation of results, and the writing of final study reports and manuscripts.
  3. To work with Clinical Resources Core and Pathology and Tissue Resource Core in the development of research project database, to maintain data quality control and to ensure timely data capture.
  4. To develop and evaluate statistical methods for experimental design and data analysis.

The Biostatistics Core support is required in all Lung Cancer SPORE studies. Core personnel have worked and will continue to work closely with project leaders for assuring that Core provides state-of-the-art statistical support.