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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Clinical Information and Biospecimen Collection from Patients with Recurrent or Stage IV Breast Cancer

This trial collects clinical information and tissue and blood samples from patients with breast cancer that has come back or is stage IV. Collecting clinical information and biospecimen samples to create a registry may help doctors better understand the mechanism of tumor spread and determine why people respond differently to specific cancer treatments.
Not Available
Not Available
Park, Ben
Vanderbilt University


18 Years
Inclusion Criteria:

Histologically confirmed or suspected invasive breast cancer

Radiographic evidence of distant metastatic disease

Clinical or radiographic evidence of disease progression OR presenting with de novo stage IV disease

Available archived tissue from the initial breast primary (formalin fixed paraffin embedded [FFPE] tissue is acceptable; fresh frozen tissue is preferred if available)

Accessible lesion representative of recurrent or metastatic breast cancer for biopsy * Type 1 specimen collection: Patients undergoing a clinically directed tissue biopsy or tissue collection who are willing to have additional specimens taken for research during the same procedure. Sites for tissue acquisition may include the breast, skin/chest wall, lymph node/soft tissue, liver, bone, lung, brain, pleural fluid, and ascites as needed for routine clinical care * Type 2 specimen collection: Patients undergoing a tissue biopsy or tissue collection for research purposes only. Sites for tissue acquisition include the breast, skin/chest wall, lymph node/soft tissue, liver, bone, pleural fluid, and ascites. Research directed lung biopsies and brain biopsies are not permitted. Procedures for tissue acquisition are restricted to those performed under local anesthesia or intravenous (IV) conscious sedation; biopsies that require general anesthesia are not permitted in this situation

Previous cytologic confirmation of malignant pleural effusion or ascites if that is the planned source of fresh specimen collection for study participation

Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Ability to understand and the willingness to sign an informed consent document

Exclusion Criteria:

Concurrent disease or condition that in the opinion of the treating oncologist or the provider performing the biopsy procedure renders the patient inappropriate for study participation

Concurrent serious medical or psychiatric disorder that may interfere with the subject’s safety during the biopsy or tissue collection procedure

Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent

History of a serious or life-threatening allergic reaction to local anesthetics (e.g., lidocaine, xylocaine) used during a biopsy procedure

Pregnancy (due to the risk of conscious sedation or anesthesia to mother and fetus)

Any condition or laboratory finding that in the opinion of the treating oncologist or the provider performing the biopsy procedure would make participation in this protocol hazardous for the patient

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