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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Phase 1 Study Of PF-06863135, A BCMA- CD3 Bispecific Ab, In Relapse / Refractory Multiple Myeloma

To assess the safety and tolerability at increasing dose levels of PF-06863135 in patients with relapse / refractory multiple myeloma in order to determine the maximum tolerated dose and select the recommended Phase 2 dose.
Not Available
Phase I
Not Available
Not Available
Cornell, Robert
Vanderbilt University


18 Years
Inclusion Criteria:

Patients with relapse/ refractory multiple myeloma

Performance Status of 0- 2 (unless due to bone pain)

Adequate bone marrow, kidney and liver function

Exclusion Criteria:

History of active autoimmune disorders

Active and clinically significant bacterial, fungal, or viral infection

Major surgery within 4 weeks of study treatment start

Radiation therapy within 2 weeks of study treatment start

Less than 30 days since last dose of anti CD38 therapy, elotuzumab or other anti-CD319 therapy or less than 5 half-lives since last dose of previous systemic therapy.

Stem cell transplant (autologous or allogeneic) within 100 days of study treatment start

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