Skip to main content

Clinical Trials Search at Vanderbilt-Ingram Cancer Center

A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition

Main study: This is an open-label, phase 2 study that aims to evaluate the efficacy and
safety/tolerability of ceralasertib, when administered as monotherapy and in combination with
durvalumab in participants with unresectable or advanced melanoma and primary or secondary
resistance to PD-(L)1 inhibition.
Phase II
Mol. targeted/Immunotherapy/Biologics
Ceralasertib, Durvalumab
Johnson, Douglas
Vanderbilt University


18 Years
Inclusion Criteria:

Participants must have a histologically or cytologically confirmed diagnosis of unresectable or metastatic melanoma of cutaneous, acral or mucosal subtype

Availability of an archival tumour sample and a fresh tumour biopsy taken at screening

Patient must have received at least 1 prior immunotherapy (anti-PD-(L)1 anti-CTLA-4 [Cytotoxic T-lymphocyte-associated protein 4]) for a minimum of 6 weeks and no more than 2 prior regimens in the metastatic setting. Patients must have confirmed progression during treatment with a PD-(L)1 inhibitor +/- a CTLA-4 inhibitor.

The interval between the last dose of anti-PD-(L)1, BRAF/MEK (B-Rapidly Accelerated Fibrosarcoma gene/mitogen-activated protein kinase gene) inhibitor and the first dose of the study regimen must be a minimum of 14 days

Measurable disease by RECIST 1.1.

Patients must have a life expectancy 3 months from proposed first dose date.

Biopsy Sub-study: Consent to the provision of 3 mandatory tumour biopsies.

Exclusion Criteria:

Patients must not have experienced a toxicity that led to permanent discontinuation of prior checkpoint inhibitors (CPI) treatment.

History of another primary malignancy except for malignancy treated with curative intent with no known active disease 3 years before the first dose of study treatment

Uveal melanoma

Must not have experienced a Grade 3 immune-related AE or an immune-related neurologic or ocular AE of any grade while receiving prior immunotherapy

History of symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, which is symptomatic or requires treatment (CTCAE Grade 3), symptomatic or uncontrolled atrial fibrillation despite treatment, or asymptomatic sustained ventricular tachycardia. Patients with atrial fibrillation controlled by medication or arrhythmias controlled by pacemakers may be permitted upon discussion with the study clinical lead.

History of organ transplant that requires use of immunosuppressive medications

Inadequate bone marrow and impaired hepatic or renal function

Known active infection requiring systemic therapy, active hepatitis infection, positive hepatitis C virus antibody, hepatitis B virus (HBV) surface antigen or HBV core antibody (anti-HBc), at screening

Patients with confirmed COVID-19 infection by polymearse chain reaction test who have not made a full recovery.

To learn more about any of our clinical
trials, call 615-936-8422.