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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin's Lymphoma (cHL), Relapsed or Refractory From First Line Treatment

The purpose of this study is to determine whether nivolumab plus brentuximab vedotin (followed by brentuximab vedotin plus bendamustine in patient with suboptimal response) is safe and effective in treating patients with Hodgkin's lymphoma (cHL). Eligible patients are children, adolescents, and young adults relapsed or refractory to first line.
Not Available
Phase II
Both
Not Available
Not Available
Friedman, Debra
International
Vanderbilt University
04-23-2019
Treatment
VICCPED1708
NCT02927769

Eligibility

5 Years
BOTH
NO
Inclusion Criteria:

Classic Hodgkin Lymphoma (cHL), relapsed or refractory

Minimal limitation on activities of daily living as measured by Karnofsky ? 50 for participants > 16 years of age or Lansky ? 50 for participants ? 16 years of age.

One prior anti-cancer therapy that did not work



Exclusion Criteria:

Active, known, or suspected autoimmune disease or infection

Active cerebral/meningeal disease related to the underlying malignancy

More than one line of anti-cancer therapy or no treatment at all

Received a stem cell transplant for Hodgkin Lymphoma and/or a solid organ transplant

Prior treatment with any drug that targets T cell co-stimulation pathways (such as checkpoint inhibitors)

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