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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus
belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab
plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell
carcinoma (ccRCC).

The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is superior to
pembrolizumab plus lenvatinib with respect to progression-free survival (PFS) and overall
survival (OS), in advanced ccRCC participants; and (2) pembrolizumab/quavonlimab plus
lenvatinib is superior to pembrolizumab plus lenvatinib with respect to PFS and OS, in
advanced ccRCC participants.
Kidney (Renal Cell)
Phase III
Adults
Mol. targeted/Immunotherapy/Biologics
Lenvatinib, MK-1308A, MK-3475, MK-6482, Pembrolizumab (MK-3475)
Beckermann, Kathryn
International
Vanderbilt University
06-16-2021
Treatment
VICCURO20101
NCT04736706

Eligibility

18 Years
BOTH
NO
Inclusion Criteria:

Has histologically confirmed diagnosis of RCC with clear cell component.

Has received no prior systemic therapy for advanced ccRCC

Male participants are abstinent from heterosexual intercourse or agree to use contraception during and for at least 7 days after last dose of study intervention with belzutifan and lenvatinib.

Female participants are not pregnant or breastfeeding and are either not a woman of child-bearing potential (WOCBP) or use a contraceptive method that is highly effective or are abstinent from heterosexual intercourse during the intervention period and for at least 120 days after pembrolizumab or pembrolizumab/quavonlimab or for at least 30 days after last dose of lenvatinib or belzutifan, whichever occurs last

Has adequately controlled blood pressure with or without antihypertensive medications

Has adequate organ function.

Participants receiving bone resorptive therapy must have therapy initiated at least 2 weeks prior to randomization/allocation



Exclusion Criteria:

Has a known additional malignancy that is progressing or has required active treatment within the past 3 years

Has had major surgery, other than nephrectomy within 4 weeks prior to randomization

Has known central nervous system (CNS) metastases and/or carcinomatous meningitis

Has received prior radiotherapy within 2 weeks prior to first dose of study intervention

Has hypoxia or requires intermittent supplemental oxygen or requires chronic supplemental oxygen

Has clinically significant cardiac disease within 12 months from first dose of study intervention

Has a history of interstitial lung disease

Has symptomatic pleural effusion; a participant who is clinically stable following treatment of this condition is eligible

Has preexisting gastrointestinal or non-gastrointestinal fistula

Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment

Has a known psychiatric or substance abuse disorder that would interfere with requirements of the study

Has received a live or live-attenuated vaccine within 30 days before the first dose of study drug; killed vaccines are allowed

Has an active autoimmune disease that has required systemic treatment in the past 2 years

Has a history of noninfectious pneumonitis that required steroids or has current pneumonitis

Has an active infection requiring systemic therapy

Has a known history of human immunodeficiency virus (HIV) infection

Has a known history of Hepatitis B

Has radiographic evidence of intratumoral cavitation, encasement or invasion of a major blood vessel

Has clinically significant history of bleeding within 3 months prior to randomization

Has had an allogenic tissue/solid organ transplant

To learn more about any of our clinical
trials, call 615-936-8422.