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Clinical Trials Search at Vanderbilt-Ingram Cancer Center



An Open-Label, Dose-Escalation / Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies

Multiple Cancer Types

This is an open-label, dose-escalation / dose-expansion study of INCB059872 in subjects with advanced malignancies. The study will be conducted in 4 parts. Part 1 (mono therapy dose escalation) will determine the recommended dose(s) of INCB059872 for dose expansion, based on maximum tolerated dose and / or a tolerated pharmacologically active dose. Part 2 (dose expansion) will further determine the safety, tolerability, efficacy, PK, and PD of the selected monotherapy dose(s) in AML / MDS, SCLC, myelofibrosis, Ewing sarcoma, and poorly differentiated neuroendocrine tumors. Part 3 will determine the recommended dose(s) of INCB059872 in combination with azacitadine and all-trans retinoic acid in AML and in combination with nivolumab in SCLC. Part 4 will further determine the safety, tolerability, efficacy, PK, and PD of the selected combination dose(s) in Part 3.
Hematologic, Leukemia, Lung, Miscellaneous, Small Cell
I/II
Savona, Michael
NCT02712905
VICCHEMP1615

A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies

Multiple Cancer Types

The purpose of this study is to determine the safety, tolerability, and efficacy of INCAGN01949 when given in combination with immune therapies in participants with advanced or metastatic malignancies.
Bladder, Breast, Cervical, Colon, Dermatologic, Endocrine, Esophageal, Gastric/Gastroesophageal, Gastrointestinal, Head/Neck, Hepatoblastoma (Pediatrics), Kidney (Renal Cell), Liver, Lung, Melanoma, Miscellaneous, Non Small Cell, Ovarian, Phase I, Rectal, Small Cell, Urologic
I/II
Davis, Nancy
NCT03241173
VICCUROP1777

ARQ 087 in Subjects With FGFR2 Gene Fusion Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma

Liver

This pivotal, open-label, single-arm study will evaluate the anti-cancer activity of ARQ 087 by Objective Response Rate (ORR) by central radiology review as per RECIST v1.1 in subjects with inoperable or advanced intrahepatic cholangiocarcinoma (iCCA) whose tumors harbor FGFR2 gene fusions (by FISH performed by the central laboratory) and who received at least one prior regimen of systemic therapy. Subjects will be dosed orally once per day at 300 mg of ARQ 087 capsules.
Liver
II
Not Available
NCT03230318
VICCGI1754

Olaparib with or without Cediranib in Treating Patients with Metastatic Castration-Resistant Prostate Cancer

Prostate

This randomized phase II trial studies how well olaparib with or without cediranib works in treating patients with castration-resistant prostate cancer that has spread to other places in the body. Olaparib and cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Prostate
II
Chism, David
NCT02893917
VICCURO1782

Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and / or HPV-18 Related Vulvar HSIL (Also Referred as: VIN)

Gynecologic

The purpose of this study is to investigate the efficacy and safety of VGX-3100 followed by electroporation (EP) with CELLECTRA™ 2000 alone or in combination with imiquimod in participants with human papillomavirus HPV-16 and / or HPV-18 related high grade squamous intraepithelial lesion (HSIL) of the vulva. In this study, all eligible participants will receive four to six doses of VGX-3100 or VGX-3100 administration in combination with imiquimod.
Gynecologic
II
Alvarez, Ronald
NCT03180684
VICCGYN17110

A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma

Sarcoma

The main purpose of this study is to evaluate the safety and efficacy of two anti-cancer drugs (gemcitabine and docetaxel) with and without the study drug known as olaratumab in participants with advanced soft tissue sarcoma (STS) or STS that has spread to another part(s) of the body.
Sarcoma
I/II
Keedy, Vicki
NCT02659020
VICCSAR15131

A Phase 2 Multicenter Study Evaluating Subjects With Relapsed / Refractory Mantle Cell Lymphoma

Lymphoma

Study KTE-C19-102 is a phase 2, multicenter, open-label study evaluating the efficacy of KTE-C19 in subjects with Relapsed / Refractory MCL
Lymphoma
II
Oluwole, Olalekan
NCT02601313
VICCBMT15116

An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)

Neuro-Oncology

The purpose of this study is to evaluate patients with glioblastoma that is MGMT-unmethylated (the MGMT gene is not altered by a chemical change). Patients will receive Nivolumab every two weeks in addition to radiation therapy, and then every four weeks. They will be compared to patients receiving standard therapy with temozolomide in addition to radiation therapy.
Neuro-Oncology
III
Clark, Stephen
NCT02617589
VICCNEU1644

FLASH [Fluorescent Light Activated Synthetic Hypericin] Clinical Study: Topical SGX301 (Synthetic Hypericin) for the Treatment of Cutaneous T-Cell Lymphoma (Mycosis Fungoides)

To evaluate the use of SGX301, a topical photosensitizing agent, to treat patients with patch / plaque phase cutaneous T-cell lymphoma (mycosis fungoides).
Not Available
III
Zwerner, Jeffrey
NCT02448381
VICCDERM1572

Neratinib HER Mutation Basket Study (SUMMIT)

Multiple Cancer Types

This is an open-label, non-randomized, multicenter, multinational, Phase 2 study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in patients with ERBB mutation-positive or EGFR gene-amplified solid tumors.
Bladder, Colon, Esophageal, Gastric/Gastroesophageal, Neuro-Oncology, Ovarian, Urologic, Uterine
II
Mayer, Ingrid
NCT01953926
VICCMD1403

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