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Clinical Trials Search at Vanderbilt-Ingram Cancer Center



An Open-Label Study of the Safety, Tolerability, and Pharmacokinetic / Pharmacodynamic Profile of VX-803 / M4344 as a Single Agent and in Combination With Cytotoxic Chemotherapy in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability of multiple ascending doses of single-agent M4344 administered twice-weekly (BIW), twice daily (BID) or once daily dose schedule in participants with advanced solid tumors. This investigation is a three part study examining M4344 alone and in combination with carboplatin, gemcitabine, and cisplatin to determine the safety and maximum tolerated dose.
Not Available
I
Not Available
NCT02278250
VICCPHI14126

PAK4 and NAMPT in Patients With Solid Malignancies or NHL (PANAMA)

This study will evaluate the safety, tolerability, and efficacy of oral KPT-9274 for the treatment of patients with advanced solid malignancies or non-Hodgkin's lymphoma (NHL).
Not Available
I
Not Available
NCT02702492
VICCPHI1616

A Dose Escalation Study of PF?06939999 in Participants With Advanced or Metastatic Solid Tumors.

This is a Phase 1, open label, multi center, dose escalation and expansion, safety, tolerability, PK, and pharmacodynamics study of PF 06939999 in previously treated patients with advanced or metastatic cancer.
Not Available
I
Not Available
NCT03854227
VICCPHI1909

Study of TJ011133 Subjects With Relapsed / Refractory Advanced Solid Tumors and Lymphoma

The purpose of this study is to assess the safety and tolerability of TJ011133 in participants with solid tumors and lymphoma.
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I
Not Available
NCT03934814
VICCPHI1944

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