Clinical Trials Search at Vanderbilt-Ingram Cancer Center
Gabapentin Compared to Usual Care in Preventing Mucositis in Participants with Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy
This randomized phase III trial studies how well gabapentin and usual care work compared to usual care alone in preventing inflammation of the mucous membranes (mucositis) in patients with stage III-IV head and neck cancer that are undergoing primary or subsequent (adjuvant) chemoradiation therapy. Radiation therapy to the head and neck may cause a burn involving the inside of the mouth, throat, and nasal passages, resulting in pain. Gabapentin may help prevent (or minimize) radiation-induced mucositis in patients with head and neck cancer.