
Abbes Belkhiri, Ph.D., M.Phil.
- Assistant Professor of Surgery
Phone
760 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6308
2220 Pierce Ave
Nashville, TN 37232-6308
Abbes Belkhiri, Ph.D., M.Phil.
- Assistant Professor of Surgery
(615) 322-8207
abbes.belkhiri@vumc.org
760 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6308
2220 Pierce Ave
Nashville, TN 37232-6308
Research Program
Departments/Affiliations
Profile
My research focuses on molecular mechanisms of chemotherapeutic resistance and targeted therapy approaches in upper GI cancers. My current research involves the role of AXL receptor tyrosine kinase in Barrett's carcinogenesis. This research attempts to gain insight into how AXL through regulation of c-ABL promotes cancer cell survival and invasion, hallmarks of tumorigenesis. This study also investigates the effects of p53 loss of function through deletion or mutation on AXL expression in the context of reflux-induced DNA damage and oxidative stress. I have also mentored and taught several postdoctoral fellows and students in the field of cancer biology in the past many years.
Education
- Ph.D., University of Manitoba, Winnipeg, Canada (1995)
- M.Phil., University of Reading, Reading, United Kingdom(1988)
Research Emphasis
Research Description
Publications
- Belkhiri A, El-Rifai W. 5-Methylcytosine hydroxylation-mediated LINE-1 hypomethylation: a novel mechanism of proto-oncogenes activation in colorectal cancer?. Gut [print-electronic]. 2014 Apr; 63(4): 538-9. PMID: 23812322, PMCID: PMC4035300, PII: gutjnl-2013-305176, DOI: 10.1136/gutjnl-2013-305176, ISSN: 1468-3288.
- Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology [print-electronic]. 2013 Dec; 145(6): 1312-22.e1. PMID: 23993973, PMCID: PMC3840093, PII: S0016-5085(13)01270-5, DOI: 10.1053/j.gastro.2013.08.050, ISSN: 1528-0012.
- Hong J, Belkhiri A. AXL mediates TRAIL resistance in esophageal adenocarcinoma. Neoplasia. 2013 Mar; 15(3): 296-304. PMID: 23479507, PMCID: PMC3593152, ISSN: 1476-5586.
- Sehdev V, Katsha A, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas. Cancer [print-electronic]. 2013 Feb 2/15/2013; 119(4): 904-14. PMID: 22972611, PMCID: PMC3524359, DOI: 10.1002/cncr.27801, ISSN: 1097-0142.
- Hong J, Peng D, Chen Z, Sehdev V, Belkhiri A. ABL regulation by AXL promotes cisplatin resistance in esophageal cancer. Cancer Res [print-electronic]. 2013 Jan 1/1/2013; 73(1): 331-40. PMID: 23117882, PII: 0008-5472.CAN-12-3151, DOI: 10.1158/0008-5472.CAN-12-3151, ISSN: 1538-7445.
- Zhu S, Hong J, Tripathi MK, Sehdev V, Belkhiri A, El-Rifai W. Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells. Mol. Cancer Res [print-electronic]. 2013 Jan; 11(1): 86-94. PMID: 23160836, PMCID: PMC3552044, PII: 1541-7786.MCR-12-0243-T, DOI: 10.1158/1541-7786.MCR-12-0243-T, ISSN: 1557-3125.
- Saad R, Chen Z, Zhu S, Jia P, Zhao Z, Washington MK, Belkhiri A, El-Rifai W. Deciphering the unique microRNA signature in human esophageal adenocarcinoma. PLoS ONE [electronic-print]. 2013; 8(5): e64463. PMID: 23724052, PMCID: PMC3665888, PII: PONE-D-12-35460, DOI: 10.1371/journal.pone.0064463, ISSN: 1932-6203.
- Hong J, Katsha A, Lu P, Shyr Y, Belkhiri A, El-Rifai W. Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma. Cancer Res [print-electronic]. 2012 Sep 9/1/2012; 72(17): 4504-14. PMID: 22745369, PMCID: PMC3432752, PII: 0008-5472.CAN-12-1119, DOI: 10.1158/0008-5472.CAN-12-1119, ISSN: 1538-7445.
- Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut [print-electronic]. 2012 Sep; 61(9): 1250-60. PMID: 22157330, PMCID: PMC3419307, PII: gutjnl-2011-301078, DOI: 10.1136/gutjnl-2011-301078, ISSN: 1468-3288.
- Belkhiri A, Zhu S, Chen Z, Soutto M, El-Rifai W. Resistance to TRAIL is mediated by DARPP-32 in gastric cancer. Clin. Cancer Res [print-electronic]. 2012 Jul 7/15/2012; 18(14): 3889-900. PMID: 22589394, PMCID: PMC3399047, PII: 1078-0432.CCR-11-3182, DOI: 10.1158/1078-0432.CCR-11-3182, ISSN: 1078-0432.