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Josh Denny, M.D., M.S.

  • Associate Professor of Biomedical Informatics
  • Associate Professor of Medicine

Phone

(615) 936-3208

Email

josh.denny@vumc.org
Vanderbilt University Medical Center
2525 West End Ave., Suite 672
Nashville, TN 37203

Josh Denny, M.D., M.S.

  • Associate Professor of Biomedical Informatics
  • Associate Professor of Medicine

(615) 936-3208

josh.denny@vumc.org

Vanderbilt University Medical Center
2525 West End Ave., Suite 672
Nashville, TN 37203

Departments/Affiliations

Provider Information

Profile

Education

  • M.S., Vanderbilt University, Nashville, Tennessee (2007)
  • M.D., Vanderbilt University, Nashville, Tennessee (2003)
  • B.S., Vanderbilt University, Nashville, Tennessee (1998)

Research Emphasis

Precision and personalized medicine, clinical phenotyping and phenomics, phenome wide association studies (PheWAS), genomics and pharmacogenomics, natural language processing

Research Description

Publications

  • Cronin RM, Fabbri D, Denny JC, Rosenbloom ST, Jackson GP. A comparison of rule-based and machine learning approaches for classifying patient portal messages. Int J Med Inform [print-electronic]. 2017 Sep; 105: 110-20. PMID: 28750904, PMCID: PMC5546247, PII: S1386-5056(17)30181-8, DOI: 10.1016/j.ijmedinf.2017.06.004, ISSN: 1872-8243.
  • Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum. Genet [print-electronic]. 2017 Aug 8/23/2017; PMID: 28836065, PII: 10.1007/s00439-017-1836-1, DOI: 10.1007/s00439-017-1836-1, ISSN: 1432-1203.
  • Karnes JH, Shaffer CM, Cronin R, Bastarache L, Gaudieri S, James I, Pavlos R, Steiner H, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Influence of human leukocyte antigen (HLA) alleles and killer cell immunoglobulin-like receptors (KIR) types on heparin-induced thrombocytopenia (HIT). Pharmacotherapy [print-electronic]. 2017 Jul 7/8/2017; PMID: 28688202, DOI: 10.1002/phar.1983, ISSN: 1875-9114.
  • Chen Y, Lask TA, Mei Q, Chen Q, Moon S, Wang J, Nguyen K, Dawodu T, Cohen T, Denny JC, Xu H. An active learning-enabled annotation system for clinical named entity recognition. BMC Med Inform Decis Mak. 2017 Jul 7/5/2017; 17(Suppl 2): 82. PMID: 28699546, PMCID: PMC5506567, PII: 10.1186/s12911-017-0466-9, DOI: 10.1186/s12911-017-0466-9, ISSN: 1472-6947.
  • Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM. Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenet. Genomics. 2017 Jul; 27(7): 247-54. PMID: 28542097, PMCID: PMC5502740, DOI: 10.1097/FPC.0000000000000284, ISSN: 1744-6880.
  • Zheng NS, Bastarache LA, Bastarache JA, Lu Y, Ware LB, Shu XO, Denny JC, Long J. A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women. J. Hum. Genet [print-electronic]. 2017 Jun 6/29/2017; PMID: 28659611, PII: jhg201766, DOI: 10.1038/jhg.2017.66, ISSN: 1435-232X.
  • Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK, Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M, Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C, Macfarlane PW, Heilmann-Heimbach S, Almgren P, Huang PL, Sotoodehnia N, Soliman EZ, Uitterlinden AG, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ, Guo X, , , Dichgans M, Ingelsson E, Kooperberg C, Melander O, Loos RJF, Laurikka J, Conen D, Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A, Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ, Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT, . Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat. Genet [print-electronic]. 2017 Jun; 49(6): 946-52. PMID: 28416818, PII: ng.3843, DOI: 10.1038/ng.3843, ISSN: 1546-1718.
  • Sperber NR, Carpenter JS, Cavallari LH, J Damschroder L, Cooper-DeHoff RM, Denny JC, Ginsburg GS, Guan Y, Horowitz CR, Levy KD, Levy MA, Madden EB, Matheny ME, Pollin TI, Pratt VM, Rosenman M, Voils CI, W Weitzel K, Wilke RA, Ryanne Wu R, Orlando LA. Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network. BMC Med Genomics. 2017 May 5/22/2017; 10(1): 35. PMID: 28532511, PMCID: PMC5441047, PII: 10.1186/s12920-017-0273-2, DOI: 10.1186/s12920-017-0273-2, ISSN: 1755-8794.
  • Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Sci Transl Med. 2017 May 5/10/2017; 9(389): PMID: 28490672, PMCID: PMC5563969, PII: 9/389/eaai8708, DOI: 10.1126/scitranslmed.aai8708, ISSN: 1946-6242.
  • Barnado A, Casey C, Carroll RJ, Wheless L, Denny JC, Crofford LJ. Developing Electronic Health Record Algorithms That Accurately Identify Patients With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) [print-electronic]. 2017 May; 69(5): 687-93. PMID: 27390187, PMCID: PMC5219863, DOI: 10.1002/acr.22989, ISSN: 2151-4658.
  • Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane JM, Cechova S, Zhou J, Tang H, Fornage M, Musani SK, Wang H, Lee J, Adeyemo A, Dreisbach AW, Forrester T, Chu PL, Cappola A, Evans MK, Morrison AC, Martin LW, Wiggins KL, Hui Q, Zhao W, Jackson RD, Ware EB, Faul JD, Reiner AP, Bray M, Denny JC, Mosley TH, Palmas W, Guo X, Papanicolaou GJ, Penman AD, Polak JF, Rice K, Taylor KD, Boerwinkle E, Bottinger EP, Liu K, Risch N, Hunt SC, Kooperberg C, Zonderman AB, Laurie CC, Becker DM, Cai J, Loos RJF, Psaty BM, Weir DR, Kardia SLR, Arnett DK, Won S, Edwards TL, Redline S, Cooper RS, Rao DC, Rotter JI, Rotimi C, Levy D, Chakravarti A, Zhu X, Franceschini N. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. PLoS Genet. 2017 May; 13(5): e1006728. PMID: 28498854, PMCID: PMC5446189, PII: PGENETICS-D-16-02810, DOI: 10.1371/journal.pgen.1006728, ISSN: 1553-7404.
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