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R. Daniel Beauchamp, M.D., F.A.C.S.

  • Co-Leader, Gastrointestinal Cancer Research Program
  • John Clinton Foshee Distinguished Professor of Surgery (Surgical Oncology)
  • Professor of Cell and Developmental Biology
  • Vice President, Cancer Center Network Affairs

Phone

615-322-2363

Email

daniel.beauchamp@Vanderbilt.Edu
Vanderbilt University Medical Center
D-4316 Medical Center North
Nashville, TN 37232-2729

R. Daniel Beauchamp, M.D., F.A.C.S.

  • Co-Leader, Gastrointestinal Cancer Research Program
  • John Clinton Foshee Distinguished Professor of Surgery (Surgical Oncology)
  • Professor of Cell and Developmental Biology
  • Vice President, Cancer Center Network Affairs

615-322-2363

daniel.beauchamp@Vanderbilt.Edu

Vanderbilt University Medical Center
D-4316 Medical Center North
Nashville, TN 37232-2729

Profile

Dr. Beauchamp is the John Clinton Foshee Distinguished Professor of Surgery and a Professor of Cell and Developmental Biology. He also serves co-leader of the Gastrointestinal Cancer Research Program. Dr. Beauchamp is the former Chair of the Section of Surgical Sciences and Surgeon-in-Chief of Vanderbilt University Hospital, holding these positions from July 2001 to July 2018. His clinical practice encompassed Surgical Oncology including GI cancers, melanoma, sarcomas and breast cancer for almost 20 years, but is currently focused on breast cancer.

Dr. Beauchamp has two active R01 grants from NIH, and co-leads one of the main projects in the GI Cancer SPORE. His primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies. His work applies genomic, transcriptomic and proteomic technology to identify novel biomarkers and therapeutic targets in colorectal cancer. He also uses molecular genetics, chemical biology and cell biological approaches to examine mechanistic questions in cancer biology in both cell culture and mouse models. They have also developed a chemical biology project and have identified probes that inhibit Epithelial-to-Mesenchymal transition and restore E-cadherin expression in cells in which E-cadherin transcription is repressed. In addition to the basic cancer research, Dr. Beauchamp works in collaboration with his Medical Oncology and Radiation Oncology colleagues to accrue cancer patients to approved cancer clinical trials. He has trained and mentored numerous junior faculty members, physician scientist fellows, medical students, graduate students and post-doctoral fellows in his laboratory.

Education

  • M.D., The University of Texas Medical Branch, Galveston, Texas (1982)
  • B.S., Texas Tech University, Lubbock, Texas, (1978)

Research Emphasis

Transforming growth factor, Gastrointestinal carcinogenesis, Ras oncogene, colon cancer, epithelial to mesenchymal transition, metastasis, mouse models

Research Description

R. Daniel Beauchamp, MD, is the John Clinton Foshee Distinguished Professor of Surgery. He served as Chairman of the Section of Surgical Sciences, and Surgeon-in-Chief of Vanderbilt University Hospital from July 2001 through June 2018. He has been a full-time faculty member at Vanderbilt since December 1994. He holds joint appointment as professor in the department of Cell and Developmental Biology. He also served as Deputy Director of the Vanderbilt-Ingram Cancer Center from 2011 to 2019 and serves as Gastrointestinal Cancer Program Co-Leader since 2014. He was appointed Vice President for Cancer Center Network Affairs in 2018. Dr. Beauchamp has had longstanding funding support for his research from the NIH, and co-leads one of the main projects in the GI Cancer SPORE. Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies. He applies molecular genetics, chemical biology and cell biological approaches to examine mechanistic questions in cancer biology in human tissue samples, 2D and 3D cell culture and mouse models. In addition to the basic cancer research Dr. Beauchamp works in collaboration with his Medical Oncology and Radiation Oncology colleagues to accrue cancer patients to approved clinical trials. He has trained and mentored numerous junior faculty members, physician scientist fellows, medical students, graduate students and post-doctoral fellows in his laboratory. He is a member of the American Society for Clinical Investigation, the National Academy of Medicine and a fellow of the American Association for the Advancement of Science.

Publications

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