
Timothy Scott Blackwell, M.D.
- Ralph and Lulu Owen Professor of Medicine (Allergy, Pulmonary, and Critical Care Medicine)
- Professor of Cell and Developmental Biology
- Director, Division of Allergy, Pulmonary and Critical Care Medicine
Phone
1161 21st Ave. S
Suite T-1218 MCN
Nashville, TN 37232-2650
Timothy Scott Blackwell, M.D.
- Ralph and Lulu Owen Professor of Medicine (Allergy, Pulmonary, and Critical Care Medicine)
- Professor of Cell and Developmental Biology
- Director, Division of Allergy, Pulmonary and Critical Care Medicine
615-343-4761
timothy.blackwell@vumc.org
1161 21st Ave. S
Suite T-1218 MCN
Nashville, TN 37232-2650
Research Program
Departments/Affiliations
Profile
Education
- M.D., University of Alabama, Birmingham, Alabama (1988)
- B.A., Vanderbilt University, Nashville, Tennessee (1983)
Postgraduate Training
- Fellowship - Vanderbilt University Medical Center, 1992
- Residency - Washington University Medical Center, 1991
- Internship - Washington University Medical Center, 1989
Research Emphasis
NF-kappaB,Lung,Inflammation,Fibrosis,Transgenic,Epithelial cells,Macrophages
Research Description
My laboratory investigates lung inflamamtion/injury, remodeling, fibrosis, and development of lung cancer. Lung inflammation is important for host defense functions but can contribute to tissue injury when the inflammation is excessive or dysregulated. By studying the NF-kB transcription pathway, we hope to better understand factors that control lung inflammation, injury, and host defense. We are also interested in the basic mechanisms that lead to normal lung repair or fibrosis following injury and mechanisms by which chronic inflammation alters the lung microenvironment in a pro-tumorigenic manner.
Publications
- Burman A, Tanjore H, Blackwell TS. Endoplasmic reticulum stress in pulmonary fibrosis. Matrix Biol [print-electronic]. 2018 Aug; 68-69: 355-65. PMID: 29567124, PII: S0945-053X(17)30474-2, DOI: 10.1016/j.matbio.2018.03.015, ISSN: 1569-1802.
- Dressen A, Abbas AR, Cabanski C, Reeder J, Ramalingam TR, Neighbors M, Bhangale TR, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco K, Tom J, Cowgill A, Vogel J, Forrest WF, Collard HR, Wolters PJ, Kropski JA, Lancaster LH, Blackwell TS, Arron JR, Yaspan BL. Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study. Lancet Respir Med [print-electronic]. 2018 Jun 6/8/2018; PMID: 29891356, PII: S2213-2600(18)30135-8, DOI: 10.1016/S2213-2600(18)30135-8, ISSN: 2213-2619.
- Vreka M, Lilis I, Papageorgopoulou M, Giotopoulou GA, Lianou M, Giopanou I, Kanellakis NI, Spella M, Agalioti T, Armenis V, Goldmann T, Marwitz S, Yull FE, Blackwell TS, Pasparakis M, Marazioti A, Stathopoulos GT. I¿B Kinase a Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. Cancer Res [print-electronic]. 2018 Jun 6/1/2018; 78(11): 2939-51. PMID: 29588349, PII: 0008-5472.CAN-17-1944, DOI: 10.1158/0008-5472.CAN-17-1944, ISSN: 1538-7445.
- Richmond BW, Du RH, Han W, Benjamin JT, van der Meer R, Gleaves L, Guo M, McKissack A, Zhang Y, Cheng DS, Polosukhin VV, Blackwell TS. Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease. Am. J. Respir. Cell Mol. Biol. 2018 Jun; 58(6): 736-44. PMID: 29314863, PMCID: PMC6002662, DOI: 10.1165/rcmb.2017-0329OC, ISSN: 1535-4989.
- Finch DK, Stolberg VR, Ferguson J, Alikaj H, Kady MR, Richmond BW, Polosukhin VV, Blackwell TS, McCloskey L, Curtis JL, Freeman CM. Lung Dendritic Cells Drive NK Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Ra. Am. J. Respir. Crit. Care Med [print-electronic]. 2018 Apr 4/20/2018; PMID: 29676596, DOI: 10.1164/rccm.201712-2513OC, ISSN: 1535-4970.
- Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS. P52 expression enhances lung cancer progression. Sci Rep. 2018 Apr 4/17/2018; 8(1): 6078. PMID: 29666445, PMCID: PMC5904214, PII: 10.1038/s41598-018-24488-8, DOI: 10.1038/s41598-018-24488-8, ISSN: 2045-2322.
- Benjamin JT, van der Meer R, Slaughter JC, Steele S, Plosa EJ, Sucre JM, Moore PE, Aschner JL, Blackwell TS, Young LR. Inverse Relationship between Soluble RAGE and Risk for Bronchopulmonary Dysplasia. Am. J. Respir. Crit. Care Med. 2018 Apr 4/15/2018; 197(8): 1083-6. PMID: 29035091, PMCID: PMC5909162, DOI: 10.1164/rccm.201707-1445LE, ISSN: 1535-4970.
- Sucre JMS, Jetter CS, Loomans H, Williams J, Plosa EJ, Benjamin JT, Young LR, Kropski JA, Calvi CL, Kook S, Wang P, Gleaves L, Eskaros A, Goetzl L, Blackwell TS, Guttentag SH, Zijlstra A. Successful Establishment of Primary Type 2 Alveolar Epithelium with 3D Organotypic Co-culture. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2018 Apr 4/6/2018; PMID: 29625013, DOI: 10.1165/rcmb.2017-0442MA, ISSN: 1535-4989.
- Hewlett JC, Kropski JA, Blackwell TS. Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol [print-electronic]. 2018 Apr 4/3/2018; PMID: 29625182, PII: S0945-053X(18)30108-2, DOI: 10.1016/j.matbio.2018.03.021, ISSN: 1569-1802.
- Sucre JMS, Deutsch GH, Jetter CS, Ambalavanan N, Benjamin JT, Gleaves LA, Millis BA, Young LR, Blackwell TS, Kropski JA, Guttentag SH. A Shared Pattern of ß-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis. Am. J. Pathol [print-electronic]. 2018 Apr; 188(4): 853-62. PMID: 29355514, PMCID: PMC5866104, PII: S0002-9440(17)30901-X, DOI: 10.1016/j.ajpath.2017.12.004, ISSN: 1525-2191.
- Lentz RJ, Taylor TM, Kropski JA, Sandler KL, Johnson JE, Blackwell TS, Maldonado F, Rickman OB. Utility of Flexible Bronchoscopic Cryobiopsy for Diagnosis of Diffuse Parenchymal Lung Diseases. J Bronchology Interv Pulmonol. 2018 Apr; 25(2): 88-96. PMID: 28796717, PMCID: PMC5803464, DOI: 10.1097/LBR.0000000000000401, ISSN: 1948-8270.