The cytoplasmic DNA-sensing pathway involving the proteins cGAS and STING are potent tumor immunosurveillance factors. Activation of STING leads to the upregulation of cytokines, notably tumor necrosis alpha. Several studies have shown that pharmacological stimulation of the cGAS-STING pathway can be effective in mitigating tumor progression in colorectal and non-small cell lung carcinoma murine models. My laboratory aims to understand the basic mechanisms governing cGAS and STING activation and regulation, as well as investigating post-transcriptional regulatory control of mRNAs encoding for cytokines. Moreover, we are engaged in identifying and characterizing small molecule agonists and antagonists of the cGAS-STING pathway.