Xingyi Guo, Ph.D.
- Associate Professor of Medicine
Phone
Vanderbilt University Medical Center
2525 West End, Suite 330
Nashville, TN 37203
2525 West End, Suite 330
Nashville, TN 37203
Xingyi Guo, Ph.D.
- Associate Professor of Medicine
(615) 936-3471
xingyi.guo@vumc.org
Vanderbilt University Medical Center
2525 West End, Suite 330
Nashville, TN 37203
2525 West End, Suite 330
Nashville, TN 37203
Research Program
Departments/Affiliations
Profile
Research Keywords
Bioinformatics, functional genomics, epigenomics, genetic epidemiology, cancer research
Education
- Ph.D., Zhejiang University, Hangzhou, China
- B.S., Anhui Science and Technology University, Anhui, China
- Postdoctoral Fellow, Bioinformatics and Functional Genomics, Dept. of Neurology, Albert Einstein College of Medicine of Yeshiva University, NY
Research Emphasis
Bioinformatics, functional genomics, epigenetics, genetic epidemiology, cancer research
Research Description
Publications
- Wang S, Beeghly-Fadiel A, Cai Q, Cai H, Guo X, Shi L, Wu J, Ye F, Qiu Q, Zheng Y, Zheng W, Bao PP, Shu XO. Gene expression in triple-negative breast cancer in relation to survival. Breast Cancer Res. Treat [print-electronic]. 2018 May 5/10/2018; PMID: 29748761, PII: 10.1007/s10549-018-4816-9, DOI: 10.1007/s10549-018-4816-9, ISSN: 1573-7217.
- Guo X, Lin W, Bao J, Cai Q, Pan X, Bai M, Yuan Y, Shi J, Sun Y, Han MR, Wang J, Liu Q, Wen W, Li B, Long J, Chen J, Zheng W. A Comprehensive cis-eQTL Analysis Revealed Target Genes in Breast Cancer Susceptibility Loci Identified in Genome-wide Association Studies. Am. J. Hum. Genet. 2018 May 5/3/2018; 102(5): 890-903. PMID: 29727689, PII: S0002-9297(18)30105-8, DOI: 10.1016/j.ajhg.2018.03.016, ISSN: 1537-6605.
- Liu M, Zhu J, Wu S, Wang C, Guo X, Wu J, Zhou M. De novo assembly and analysis of the Artemisia argyi transcriptome and identification of genes involved in terpenoid biosynthesis. Sci Rep. 2018 Apr 4/11/2018; 8(1): 5824. PMID: 29643397, PMCID: PMC5895812, PII: 10.1038/s41598-018-24201-9, DOI: 10.1038/s41598-018-24201-9, ISSN: 2045-2322.
- Guo X, Shi J, Cai Q, Shu XO, He J, Wen W, Allen J, Pharoah P, Dunning A, Hunter DJ, Kraft P, Easton DF, Zheng W, Long J. Use of deep whole-genome sequencing data to identify structure risk variants in breast cancer susceptibility genes. Hum. Mol. Genet. 2018 Mar 3/1/2018; 27(5): 853-9. PMID: 29325031, PII: 4793000, DOI: 10.1093/hmg/ddy005, ISSN: 1460-2083.
- Seki Y, Suzuki M, Guo X, Glenn AS, Vuguin PM, Fiallo A, Du Q, Ko YA, Yu Y, Susztak K, Zheng D, Greally JM, Katz EB, Charron MJ. In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice. Endocrinology. 2017 Sep 9/1/2017; 158(9): 2860-72. PMID: 28911167, PMCID: PMC5659663, PII: 3882533, DOI: 10.1210/en.2017-00334, ISSN: 1945-7170.
- Wen W, Shu XO, Guo X, Cai Q, Long J, Bolla MK, Michailidou K, Dennis J, Wang Q, Gao YT, Zheng Y, Dunning AM, García-Closas M, Brennan P, Chen ST, Choi JY, Hartman M, Ito H, Lophatananon A, Matsuo K, Miao H, Muir K, Sangrajrang S, Shen CY, Teo SH, Tseng CC, Wu AH, Yip CH, Simard J, Pharoah PD, Hall P, Kang D, Xiang Y, Easton DF, Zheng W. Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. Breast Cancer Res. 2016 Dec 12/8/2016; 18(1): 124. PMID: 27931260, PMCID: PMC5146840, PII: 10.1186/s13058-016-0786-1, DOI: 10.1186/s13058-016-0786-1, ISSN: 1465-542X.
- Zhang Y, Wagner EK, Guo X, May I, Cai Q, Zheng W, He C, Long J. Long intergenic non-coding RNA expression signature in human breast cancer. Sci Rep. 2016 Nov 11/29/2016; 6: 37821. PMID: 27897201, PMCID: PMC5126689, PII: srep37821, DOI: 10.1038/srep37821, ISSN: 2045-2322.
- Johnson DB, Frampton GM, Rioth MJ, Yusko E, Xu Y, Guo X, Ennis RC, Fabrizio D, Chalmers ZR, Greenbowe J, Ali SM, Balasubramanian S, Sun JX, He Y, Frederick DT, Puzanov I, Balko JM, Cates JM, Ross JS, Sanders C, Robins H, Shyr Y, Miller VA, Stephens PJ, Sullivan RJ, Sosman JA, Lovly CM. Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade. Cancer Immunol Res [print-electronic]. 2016 Nov; 4(11): 959-67. PMID: 27671167, PMCID: PMC5134329, PII: 2326-6066.CIR-16-0143, DOI: 10.1158/2326-6066.CIR-16-0143, ISSN: 2326-6074.
- Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Dennis J, Lush M, Milne RL, Shu XO, Beesley J, Kar S, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Zhao Z, Guo X, Benitez J, Beeghly-Fadiel A, Blot W, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Brinton L, Broeks A, Brüning T, Burwinkel B, Cai H, Canisius S, Chang-Claude J, Choi JY, Couch FJ, Cox A, Cross SS, Czene K, Darabi H, Devilee P, Droit A, Dork T, Fasching PA, Fletcher O, Flyger H, Fostira F, Gaborieau V, García-Closas M, Giles GG, Grip M, Guenel P, Haiman CA, Hamann U, Hartman M, Miao H, Hollestelle A, Hopper JL, Hsiung CN, , Ito H, Jakubowska A, Johnson N, Torres D, Kabisch M, Kang D, Khan S, Knight JA, Kosma VM, Lambrechts D, Li J, Lindblom A, Lophatananon A, Lubinski J, Mannermaa A, Manoukian S, Le Marchand L, Margolin S, Marme F, Matsuo K, McLean C, Meindl A, Muir K, Neuhausen SL, Nevanlinna H, Nord S, Børresen-Dale AL, Olson JE, Orr N, van den Ouweland AM, Peterlongo P, Choudary Putti T, Rudolph A, Sangrajrang S, Sawyer EJ, Schmidt MK, Schmutzler RK, Shen CY, Hou MF, Shrubsole MJ, Southey MC, Swerdlow A, Hwang Teo S, Thienpont B, Toland AE, Tollenaar RA, Tomlinson I, Truong T, Tseng CC, Wen W, Winqvist R, Wu AH, Har Yip C, Zamora PM, Zheng Y, Floris G, Cheng CY, Hooning MJ, Martens JW, Seynaeve C, Kristensen VN, Hall P, Pharoah PD, Simard J, Chenevix-Trench G, Dunning AM, Antoniou AC, Easton DF, Cai Q, Long J. Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Int. J. Cancer [print-electronic]. 2016 Sep 9/15/2016; 139(6): 1303-17. PMID: 27087578, PMCID: PMC5110427, DOI: 10.1002/ijc.30150, ISSN: 1097-0215.
- Guo X, Delio M, Haque N, Castellanos R, Hestand MS, Vermeesch JR, Morrow BE, Zheng D. Variant discovery and breakpoint region prediction for studying the human 22q11.2 deletion using BAC clone and whole genome sequencing analysis. Hum. Mol. Genet [print-electronic]. 2016 Sep 9/1/2016; 25(17): 3754-67. PMID: 27436579, PMCID: PMC5216616, PII: ddw221, DOI: 10.1093/hmg/ddw221, ISSN: 1460-2083.
