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This clinical trial evaluates the clinical effectiveness of a multi-level telehealth-based intervention for cancer patients in rural communities. Rural residents face limited accessibility to cancer treatment and supportive care services, transportation barriers, and financial issues. Cancer Thriving and Surviving is an evidence-based self-management intervention with demonstrated efficacy across numerous chronic health conditions with dissemination across the US, inclusive of rural communities. This trial evaluates whether the evidence-based Cancer Thriving and Surviving intervention delivered through telehealth among rural patients may improve patient outcomes.

This trial studies the impact of indwelling tunneled pleural drainage systems (gravity or vacuum based) on pain in patients with plural effusion that has come back (recurrent). Vacuum drainage and gravity drainage are two commonly used drainage methods. Studying the best drainage methods may help future patients undergoing indwelling tunneled pleural catheter placement.

This phase II trial studies the treatment response for patients with acute graft-versus-host disease (GVHD). GVHD occurs when donor immune cells attack the healthy tissue of a bone marrow or stem cell transplant patient. The standard treatment for GVHD is to lower the activity of the donor cells by using steroid medications such as prednisone. But steroid treatment may cause many complications and the risk of these complications increases with higher doses of steroids and longer treatment. It is important to find ways to decrease the steroid treatment in patients who do not need long courses. Researchers are doing this study to find out how many subjects respond well to lower steroid dosing based on a blood test (GVHD biomarker) and if they develop fewer complications.

This clinical trial tests virtual reality (VR) in the management of pain, stress, and feelings or emotions (affect) in patients undergoing treatment for cancer in infusion clinics. Patients receiving treatment in infusion clinics are often sitting in a single location for an extended period of time which can lead to high levels of anxiety, pain, and depression. VR technology can create and immersive, computer-generated experience that a patient can interact with and navigate through. Because of the immersive nature of VR, this therapeutic technology could positively impact pain, stress, and/or affect of cancer patients undergoing treatment.

This phase IV trial assesses the safety and feasibility of receiving chimeric antigen receptor (CAR) T cell therapy with YESCARTA in the outpatient setting, with fewer days spent as a patient in the hospital. YESCARTA is made from your own white blood cells, which will be modified in a laboratory to recognize and attack your lymphoma cells. Because YESCARTA is a specialized and fairly new therapy, patients currently receiving YESCARTA are typically required to spend several days in the hospital even if their treatment is well tolerated. This trial may help doctors determine if it is safe and feasible to give YESCARTA in the outpatient setting, with fewer days spent as a patient in the hospital.

This clinical trial determines if a if a web-based educational program, The Body Image after Head and Neck Cancer Treatment Program, is feasible and acceptable to patients who have been treated for head and neck cancer and have body image concerns. This program may provide a low-cost, easily accessible way for head and neck cancer survivors to address and navigate through body image concerns after treatment.

This clinical trial tests whether neuroplasticity-based computerized cognitive remediation works in improving certain types of thinking skills that are important for daily life functioning in breast cancer patients with chemotherapy-related cognitive impairment. Cancer and chemotherapy treatment may change the way the brain functions. As a result, patients who receive cancer treatment may experience problems with their attention, learning, and memory that they did not have before. nCCR is a computer-based program designed to improve certain types of thinking skills that are important for daily life functioning. nCCR may help improve thinking and functioning in patients with attention and memory problems related to cancer treatment.

This clinical trial studies the effect of the ERAS pain management method in managing pain after surgery in patients with extremity soft tissue sarcoma. Enhanced Recovery After Surgery, or ERAS, is a pain management method that places emphasis on managing risk factors (things like smoking, nutrition and fitness), using multiple types of pain control, and early movement, with the goal of improving patient outcomes. ERAS has been shown to reduce the length of time some patients stay in the hospital, reduce complications from surgery, and even lower costs of some surgeries. ERAS is designed may help cut down on the use of these narcotics in managing the pain of surgery patients. The purpose of this trial is to demonstrate that ERAS is safe and effective for patients having surgery to treat their sarcoma. Specifically, this study will look at using a non-narcotic pain management program that includes other methods of managing the pain of sarcoma surgery patients.

This clinical trial explores the impact of human-animal interactions on children with life-threatening conditions and their parent. Studies have shown that animals can be entertaining and promote relaxation and comfort during stressful events. Having animal-assisted interaction visits on a routine basis, with a trained animal-handler and his/her dog, may make the cancer treatment process less stressful for the parent and children.

This clinical trial studies how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.