Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients with Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Multiple Cancer Types

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.

Disease Sites: Lymphoma, Miscellaneous, Pediatric Solid Tumors

Phase: N/A

Investigator: Borinstein, Scott

NCTID: NCT03155620

Protocol No: COGAPEC1621SC

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children with Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Childrens Oncology Group Study

Multiple Cancer Types

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

Disease Sites: Pediatric Leukemia, Pediatric Lymphoma, Pediatrics

Phase: N/A

Investigator: Smith, Christine

NCTID: NCT04726241

Protocol No: COGAPAL2020SC

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Improving Care after Inherited Cancer Testing (IMPACT) Study

Miscellaneous

This clinical trial investigates factors associated with access to genetic risk assessment, counseling, and testings services. The trial also seeks to refine and evaluate the effectiveness of online tools on improving cancer risk management practices and family communication of genetic test results.

Disease Sites: Miscellaneous

Phase: N/A

Investigator: Pal, Tuya

NCTID: NCT04763915

Protocol No: VICCSUPP2112

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