Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Treatment Response and Biomarker-Guided Steroid Taper for Children with GVHD

Multiple Cancer Types

This phase II trial studies the treatment response for patients with acute graft-versus-host disease (GVHD). GVHD occurs when donor immune cells attack the healthy tissue of a bone marrow or stem cell transplant patient. The standard treatment for GVHD is to lower the activity of the donor cells by using steroid medications such as prednisone. But steroid treatment may cause many complications and the risk of these complications increases with higher doses of steroids and longer treatment. It is important to find ways to decrease the steroid treatment in patients who do not need long courses. Researchers are doing this study to find out how many subjects respond well to lower steroid dosing based on a blood test (GVHD biomarker) and if they develop fewer complications.

Disease Sites: Miscellaneous, Pediatrics

Phase: II

Investigator: Kitko, Carrie

NCTID: NCT05090384

Protocol No: VICCPED2213

Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

Multiple Cancer Types

The goal of this clinical study is to learn more about the long-term safety, effectiveness
and prolonged action of Kite study drugs, axicabtagene ciloleucel, brexucabtagene autoleucel,
KITE-222, KITE-363, KITE-439, KITE-585, and KITE-718, in participants of Kite-sponsored
interventional studies.

Disease Sites: Hematologic, Leukemia, Lymphoma, Pediatric Leukemia, Pediatric Lymphoma

Phase: N/A

Investigator: Kassim, Adetola

NCTID: NCT05041309

Protocol No: VICCCTT2170

Bone Marrow Bank

Disease Sites: Not Available

Phase: N/A

Investigator: Thompson Arildsen, Mary Ann

NCTID:

Protocol No: VICCPED1522

Mount Sinai Acute Graft-versus-Host Disease International Consortium (MAGIC): A Database and Biorepository

Miscellaneous

Disease Sites: Miscellaneous

Phase: N/A

Investigator: Kitko, Carrie

NCTID:

Protocol No: VICCPED1544

A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People with Severe Von Willebrand Disease (VWD)

Hematologic

Disease Sites: Hematologic

Phase: N/A

Investigator: Wheeler, Allison

NCTID:

Protocol No: VICCNCBH19121

Prospective Validation of a Venous Thrombosis Risk Assessment Model in Critically Ill Children from the CHAT Registry

Hematologic

Disease Sites: Hematologic

Phase: N/A

Investigator: Wheeler, Allison

NCTID:

Protocol No: VICCNCBH2010

Blood based biomarkers for minimal residual disease detection in Pediatric Sarcomas

Multiple Cancer Types

Disease Sites: Pediatrics, Sarcoma

Phase: N/A

Investigator: Borinstein, Scott

NCTID:

Protocol No: VICCPED2160

CAUSAL: Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan.

Multiple Cancer Types

Disease Sites: Pediatrics, Sarcoma

Phase: N/A

Investigator: Friedman, Debra

NCTID:

Protocol No: VICCPED2222

Development and Validation of an Ancillary Diagnostic Test for Mycosis Fungoides (SIGNAL-MF)

Melanoma

Disease Sites: Melanoma

Phase: N/A

Investigator: Zwerner, Jeffrey

NCTID:

Protocol No: VICCDERM22117

Centers for Disease Control and Prevention - Community Counts: Public Health Surveillance for the Prevention of Complications of Bleeding and Clotting

Benign Hematologic

Disease Sites: Benign Hematologic

Phase: N/A

Investigator: Chi, Michelle

NCTID:

Protocol No: NCBH2301-CDC-REGISTRY

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