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Clinical Trials Search at Vanderbilt-Ingram Cancer Center



Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL

Dermatologic

This multi-center, double-blind, vehicle-controlled, randomized crossover design study will evaluate the safety and efficacy of topically applied naloxone lotion, 0.5%, for the treatment of pruritus in patients with the mycosis fungoides (MF) or Sézary syndrome (SS) Forms of Cutaneous T-cell Lymphoma (CTCL). This study will also determine if there is systemic absorption of the drug in a subset of subjects and if so, describe the range and mean plasma levels reached after two weeks of three time daily (TID) dosing. Funding Source - FDA OOPD
Dermatologic
III
Zic, John
NCT02811783
VICCDERM1798

Efficacy of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Subjects With Relapsed / Refractory Diffuse Large B Cell Lymphoma

Lymphoma

The purpose of this study is to evaluate whether axicabtagene ciloleucel therapy improves the clinical outcome compared with standard of care second-line therapy in patients with relapsed / refractory diffuse large B-cell lymphoma (DLBCL).
Lymphoma
III
Oluwole, Olalekan
NCT03391466
VICCBMT17102

Safety and Tolerability of TAR-200 in Subjects With Muscle-Invasive Bladder Cancer Who Are Unfit for Radical Cystectomy

Bladder

The purpose of this study is to determine if TAR-200, an investigational drug-delivery system, is safe and tolerable in patients with muscle-invasive bladder cancer (MIBC) who are unfit for radical cystectomy (RC) during an 84-day induction period comprised of four consecutive 21-day dosing cycles.
Bladder
I
Keegan, Kirk
NCT03404791
VICCURO17103

Percutaneous Transhepatic Biliary Drainage or Endoscopic Retrograde Cholangiography in Treating Participants with Suspected Malignant Bile Duct Obstruction

Liver

This phase III trial studies how well percutaneous transhepatic biliary drainage works versus endoscopic retrograde cholangiography in treating participants with suspected cancerous (malignant) bile duct obstruction. Percutaneous transhepatic biliary drainage is a procedure that uses x-rays to guide a needle through the skin into the bile duct to allow for drainage of the blockage through external tubes. Endoscopic retrograde cholangiography is a procedure that combines the use of a lighted camera that goes down through the mouth and x-rays to diagnose and treat certain problems of the biliary ductal system, and permits drainage of the blockage through internal stents. It is not yet known whether percutaneous transhepatic biliary drainage or endoscopic retrograde cholangiography is most effective in treating participants with suspected malignant bile duct obstruction.
Liver
N/A
Yachimski, Patrick
NCT03172832
VICCGI17104

Chemotherapy Levels in the Eyes of Patients with Retinoblastoma

Retinoblastoma (Pediatrics)

Retinoblastoma (Pediatrics)
N/A
Daniels, Anthony
VICCREACH17106

Atezolizumab and Cobimetinib or Idasanutlin in Treating Participants with Stage IV or Unresectable Recurrent Estrogen Receptor Positive Breast Cancer

Breast

This phase I / II trial studies the side effects and best dose of idasanutlin when given together with atezolizumab, and to see how well atezolizumab and cobimetinib or idasanutlin work in treating participants with stage IV estrogen-receptor positive (ER+) breast cancer, or ER+ breast cancer that has come back (recurrent) and cannot be removed by surgery (unresectable). Monoclonal antibodies, such as atezolizumab, may interfere with the ability of tumor cells to grow and spread. Cobimetinib and idasanutlin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving atezolizumab with cobimetinib or atezolizumab with idasanutlin may work better in treating participants with estrogen-receptor positive breast cancer.
Breast
I/II
Mayer, Ingrid
NCT03566485
VICCBRE17107

Developing Evidence-Based Criteria for Initiating Treatment for Neurofibromatosis Type 1 Associated Optic Pathway Glioma

Multiple Cancer Types

Neuro-Oncology, Pediatrics
N/A
Esbenshade, Adam
VICCPED17108

The Collection of Blood Samples from Patients with NF1 for Research Purposes

Multiple Cancer Types

Neuro-Oncology, Pediatrics
N/A
Esbenshade, Adam
VICCPED17109

Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and / or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3)

Gynecologic

The purpose of this study is to test the safety and efficacy of an investigational immunotherapy VGX-3100, in combination with a study device, to treat women with vulvar HSIL (VIN 2 or VIN 3) associated with HPV types 16 and / or 18. VGX-3100 is being assessed as an alternative to surgery with the potential to clear the underlying HPV infection. For more information visit our study website at: www.VINresearchstudy.com
Gynecologic
II
Alvarez, Ronald
NCT03180684
VICCGYN17110

Study of GBR 1342, a CD38 / CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma

Multiple Myeloma

The purpose of this study is to determine the safety profile and maximum tolerable dose (MTD) of single-agent GBR 1342 in subjects with multiple myeloma who have received prior therapies.
Multiple Myeloma
I
Cornell, Robert
NCT03309111
VICCHEMP17111

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