Skip to main content

Brandt F. Eichman, Ph.D.

  • William R. Kenan, Jr. Professor
  • Professor of Biological Sciences
  • Professor of Biochemistry
  • Co-Director of the Program in Biochemistry and Chemical Biology

Phone

615-936-5233

Email

brandt.eichman@Vanderbilt.Edu
Vanderbilt University Medical Center
5270A MRB III, 465 21st Ave. S.
Nashville, TN 37232

Brandt F. Eichman, Ph.D.

  • William R. Kenan, Jr. Professor
  • Professor of Biological Sciences
  • Professor of Biochemistry
  • Co-Director of the Program in Biochemistry and Chemical Biology

615-936-5233

brandt.eichman@Vanderbilt.Edu

Vanderbilt University Medical Center
5270A MRB III, 465 21st Ave. S.
Nashville, TN 37232

Profile

Education

Research Emphasis

DNA Repair, DNA Replication, Genome Maintenance, Structural Biology, X-ray Crystallography

Research Description

DNA damage arising from exposure to environmental toxins and cellular metabolites thwarts DNA replication and leads to genome instability, cell death, and diseases including cancer. Our laboratory uses the tools of structural biology and biochemistry to investigate molecular mechanisms of proteins involved in repairing DNA damage and maintaining replication fork progression. We primarily use X-ray crystallography as a starting point to understand how these proteins recognize and manipulate DNA structure to carry out their particular functions. Current work focuses on base excision repair of DNA alkylation damage by DNA glycosylases, repair of stalled replication forks by structure-specific DNA translocases, and the coordination of DNA unwinding and synthesis during eukaryotic replication. The long-term goals are to understand the fundamental processes underlying genome maintenance and to develop new therapeutic strategies that target genetic diseases.

Publications

Have any questions? Contact Us 1-877-936-8422 for more information