Olivier Boutaud, Ph.D.
- Research Associate Professor of Pharmacology and Biochemistry
Phone
Vanderbilt University Medical Center
514 Robinson Research Building
Nashville, TN 37232-6602
514 Robinson Research Building
Nashville, TN 37232-6602
Olivier Boutaud, Ph.D.
- Research Associate Professor of Pharmacology and Biochemistry
615-343-7398
olivier.boutaud@vanderbilt.edu
Vanderbilt University Medical Center
514 Robinson Research Building
Nashville, TN 37232-6602
514 Robinson Research Building
Nashville, TN 37232-6602
Research Program
-
Non-Programmatically Aligned
Departments/Affiliations
Profile
Education
Research Emphasis
Research Description
Publications
- Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM. Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1. Bioorg Med Chem Lett [print-electronic]. 2021 Sep 9/1/2021; 47: 128193. PMID: 34118412, PMCID: PMC8349895, PII: S0960-894X(21)00420-0, DOI: 10.1016/j.bmcl.2021.128193, ISSN: 1464-3405.
- Kent CN, Fulton MG, Stillwell KJ, Dickerson JW, Loch MT, Rodriguez AL, Blobaum AL, Boutaud O, Rook JL, Niswender CM, Conn PJ, Lindsley CW. Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model. Bioorg Med Chem Lett [print-electronic]. 2021 Apr 4/1/2021; 37: 127838. PMID: 33556572, PII: S0960-894X(21)00064-0, DOI: 10.1016/j.bmcl.2021.127838, ISSN: 1464-3405.
- Gobert AP, Boutaud O, Asim M, Zagol-Ikapitte IA, Delgado AG, Latour YL, Finley JL, Singh K, Verriere TG, Allaman MM, Barry DP, McNamara KM, Sierra JC, Amarnath V, Tantawy MN, Bimczok D, Piazuelo MB, Washington MK, Zhao S, Coburn LA, Wilson KT. Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis. Gastroenterology [print-electronic]. 2021 Mar; 160(4): 1256-1268.e9. PMID: 33189701, PMCID: PMC7956217, PII: S0016-5085(20)35394-4, DOI: 10.1053/j.gastro.2020.11.006, ISSN: 1528-0012.
- Davis DC, Bungard JD, Chang S, Rodriguez AL, Blobaum AL, Boutaud O, Melancon BJ, Niswender CM, Jeffrey Conn P, Lindsley CW. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs. Bioorg Med Chem Lett [print-electronic]. 2021 Jan 1/15/2021; 32: 127724. PMID: 33253881, PII: S0960-894X(20)30835-0, DOI: 10.1016/j.bmcl.2020.127724, ISSN: 1464-3405.
- Dikalova A, Mayorov V, Xiao L, Panov A, Amarnath V, Zagol-Ikapitte I, Vergeade A, Ao M, Yermalitsky V, Nazarewicz RR, Boutaud O, Lopez MG, Billings FT, Davies S, Roberts LJ, Harrison DG, Dikalov S. Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension. Hypertension [print-electronic]. 2020 Dec; 76(6): 1980-91. PMID: 33012204, PMCID: PMC7666054, DOI: 10.1161/HYPERTENSIONAHA.120.15236, ISSN: 1524-4563.
- Tao H, Huang J, Yancey PG, Yermalitsky V, Blakemore JL, Zhang Y, Ding L, Zagol-Ikapitte I, Ye F, Amarnath V, Boutaud O, Oates JA, Roberts LJ, Davies SS, Linton MF. Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice. Nat Commun. 2020 Aug 8/14/2020; 11(1): 4084. PMID: 32796843, PMCID: PMC7429830, PII: 10.1038/s41467-020-17915-w, DOI: 10.1038/s41467-020-17915-w, ISSN: 2041-1723.
- Prinsen JK, Kannankeril PJ, Sidorova TN, Yermalitskaya LV, Boutaud O, Zagol-Ikapitte I, Barnett JV, Murphy MB, Subati T, Stark JM, Christopher IL, Jafarian-Kerman SR, Saleh MA, Norlander AE, Loperena R, Atkinson JB, Fogo AB, Luther JM, Amarnath V, Davies SS, Kirabo A, Madhur MS, Harrison DG, Murray KT. Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension. JACC Basic Transl Sci. 2020 Jun; 5(6): 602-15. PMID: 32613146, PMCID: PMC7315188, PII: S2452-302X(20)30165-0, DOI: 10.1016/j.jacbts.2020.04.004, ISSN: 2452-302X.
- Pitchford LM, Driver PM, Fuller JC, Akers WS, Abumrad NN, Amarnath V, Milne GL, Chen SC, Ye F, Roberts LJ, Shoemaker MB, Oates JA, Rathmacher JA, Boutaud O. Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial. BMC Pharmacol Toxicol. 2020 Jan 1/6/2020; 21(1): 3. PMID: 31907026, PMCID: PMC6945443, PII: 10.1186/s40360-020-0382-y, DOI: 10.1186/s40360-020-0382-y, ISSN: 2050-6511.
- Davies SS, May-Zhang LS, Boutaud O, Amarnath V, Kirabo A, Harrison DG. Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions. Pharmacol Ther [print-electronic]. 2020 Jan; 205: 107418. PMID: 31629006, PMCID: PMC7495735, PII: S0163-7258(19)30170-6, DOI: 10.1016/j.pharmthera.2019.107418, ISSN: 1879-016X.
- Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A. Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension. Am J Physiol Heart Circ Physiol [print-electronic]. 2019 Mar 3/1/2019; 316(3): H639-H646. PMID: 30608177, PMCID: PMC6459311, DOI: 10.1152/ajpheart.00595.2018, ISSN: 1522-1539.
