Skip to main content

Patrick Hu, M.D., Ph.D.

  • Associate Professor of Medicine
  • Associate Professor of Cell and Developmental Biology

Phone

(615) 322-4967

Email

patrick.j.hu@vanderbilt.edu
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307

Patrick Hu, M.D., Ph.D.

  • Associate Professor of Medicine
  • Associate Professor of Cell and Developmental Biology

(615) 322-4967

patrick.j.hu@vanderbilt.edu

777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307

Profile

My lab studies a conserved insulin-like growth factor (IGF)/PTEN/PI 3-kinase (PI3K)/Akt/FoxO signaling pathway using the nematode worm Caenorhabditis elegans and mice as model systems. The IGF/PTEN/PI3K/Akt pathway is one of the most commonly dysregulated signaling pathways in human cancer. Therefore, understanding the mechanistic underpinnings of both its normal function as well as its dysfunction in cancer will lead to new approaches to prevent, diagnose, and manage a wide variety of human cancers.

Our research strategy involves leveraging the C. elegans experimental tool kit to reveal insights into conserved aspects of IGF/PTEN/PI3K/Akt pathway regulation and function, and exploring the impact of these insights on disease pathogenesis in mouse models of cancer and other human diseases. As IGF signaling plays an important and conserved role in controlling aging in animals, one prominent aspect of our work is to use our understanding of how this pathway influences longevity in C. elegans to elucidate the role that aging plays in the pathogenesis of cancer and other diseases that are commonly seen in elderly humans.

Education

  • M.D., New York University, New York, New York (1995)
  • Ph.D., New York University, New York, New York (1995)
  • A.B., Harvard University, Cambridge, Massachusetts (1985)

POSTGRADUATE TRAINING

  • Intern and Residency in Internal Medicine, The Johns Hopkins Hospital
  • Fellowship in Adult Oncology, Dana-Farber/Partners Cancer Care

Research Emphasis

Research Description

My lab studies the role of insulin-like growth factor signaling in development, metabolism, and aging, using the nematode C. elegans and mice as model systems.

Publications

Have any questions? Contact Us 1-877-936-8422 for more information